Details of the Drug Combination

General Information of Drug Combination (ID: DC3DDW2)

Drug Combination Name
Fluorouracil Gemcitabine
Indication
Disease Entry Status REF
Adenocarcinoma Investigative [1]
Component Drugs Fluorouracil   DMUM7HZ Gemcitabine   DMSE3I7
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: HT29
Zero Interaction Potency (ZIP) Score: 2.81
Bliss Independence Score: 3.41
Loewe Additivity Score: 4.42
LHighest Single Agent (HSA) Score: 10.89

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Fluorouracil
Disease Entry ICD 11 Status REF
Adenocarcinoma 2D40 Approved [2]
Biliary tract cancer 2C17 Approved [2]
Colon adenocarcinoma N.A. Approved [2]
Esophageal squamous cell carcinoma 2E60.1 Approved [2]
Gastric intestinal type adenocarcinoma N.A. Approved [2]
Gastroesophageal junction adenocarcinoma 2B71 Approved [2]
Metastasis from malignant tumor of colon N.A. Approved [2]
Pancreatic adenocarcinoma N.A. Approved [2]
Rectal adenocarcinoma 2B92 Approved [2]
Rectum mucinous adenocarcinoma N.A. Approved [2]
Solid tumour/cancer 2A00-2F9Z Approved [3]
Colon cancer 2B90.Z Investigative [2]
Colon mucinous adenocarcinoma N.A. Investigative [2]
Colorectal cancer 2B91.Z Investigative [4]
Gastric cancer 2B72 Investigative [2]
Tumour 2A00-2F9Z Investigative [5]
Fluorouracil Interacts with 4 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
TERT messenger RNA (TERT mRNA) TTQY2EJ TERT_HUMAN . [5]
Candida Thymidylate synthase (Candi TMP1) TTU6BFZ TYSY_CANAL Inhibitor [42]
Dihydrothymine dehydrogenase (DPYD) TTZPS91 DPYD_HUMAN Inhibitor [43]
Thymidylate synthase messenger RNA (TYMS mRNA) TTP1UKZ TYSY_HUMAN . [5]
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Fluorouracil Interacts with 8 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [44]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [45]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [46]
Organic anion transporter 2 (SLC22A7) DT0OC1Q S22A7_HUMAN Substrate [47]
Multidrug resistance-associated protein 3 (ABCC3) DTQ3ZHF MRP3_HUMAN Substrate [48]
Multidrug resistance-associated protein 4 (ABCC4) DTCSGPB MRP4_HUMAN Substrate [48]
Multidrug resistance-associated protein 5 (ABCC5) DTYVM24 MRP5_HUMAN Substrate [48]
Equilibrative nucleoside transporter 1 (SLC29A1) DTXD1TQ S29A1_HUMAN Substrate [49]
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⏷ Show the Full List of 8 DTP(s)
Fluorouracil Interacts with 12 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [50]
Cytochrome P450 2A6 (CYP2A6) DEJVYAZ CP2A6_HUMAN Metabolism [50]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [50]
Dihydrothymine dehydrogenase (DPYD) DESOEW1 DPYD_HUMAN Metabolism [51]
Methylenetetrahydrofolate reductase (MTHFR) DEOXTPZ MTHR_HUMAN Metabolism [52]
Thymidine phosphorylase (TYMP) DE4HCYL TYPH_HUMAN Metabolism [52]
Amidophosphoribosyltransferase (GPAT) DEMJ7R2 PUR1_HUMAN Metabolism [53]
Thymidylate synthase (TYMS) DEASG0Q TYSY_HUMAN Metabolism [52]
Uridine 5'-monophosphate synthase (UMPS) DEWJYTE UMPS_HUMAN Metabolism [54]
Uridine phosphorylase 1 (UPP1) DEFZWAX UPP1_HUMAN Metabolism [55]
Uridine phosphorylase 2 (UPP2) DEBQ2WU UPP2_HUMAN Metabolism [55]
Uracil phosphoribosyltransferase (UPRT) DE20ETR UPP_HUMAN Metabolism [56]
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⏷ Show the Full List of 12 DME(s)
Fluorouracil Interacts with 1026 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 2A6 (CYP2A6) OT52TWG3 CP2A6_HUMAN Increases Chemical Synthesis [57]
Methylenetetrahydrofolate reductase (MTHFR) OTUBJSR7 MTHR_HUMAN Increases Response To Substance [58]
Dihydropyrimidine dehydrogenase (DPYD) OTWRF2NR DPYD_HUMAN Increases Response To Substance [59]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Decreases Expression [60]
Equilibrative nucleoside transporter 1 (SLC29A1) OTLOOZZS S29A1_HUMAN Increases Expression [61]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Affects Response To Substance [37]
ATP-binding cassette sub-family C member 5 (ABCC5) OT34G4US MRP5_HUMAN Decreases Response To Substance [48]
Solute carrier family 22 member 7 (SLC22A7) OTKTNH1W S22A7_HUMAN Increases Transport [47]
Glutathione S-transferase P (GSTP1) OTLP0A0Y GSTP1_HUMAN Increases Expression [14]
Nitric oxide synthase, inducible (NOS2) OTKKIOJ1 NOS2_HUMAN Increases Expression [62]
Fanconi anemia group G protein (FANCG) OT7MC8TZ FANCG_HUMAN Increases Expression [11]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L) OTJKOMXE BNI3L_HUMAN Decreases Expression [11]
Dihydrofolate reductase (DHFR) OT3DVIGM DYR_HUMAN Increases Expression [11]
Annexin A4 (ANXA4) OTUCRYXL ANXA4_HUMAN Decreases Expression [11]
Thymidylate kinase (DTYMK) OTJXYQYK KTHY_HUMAN Increases Expression [11]
Flap endonuclease 1 (FEN1) OT6QGG7O FEN1_HUMAN Increases Expression [11]
Interleukin-1 receptor-associated kinase 1 (IRAK1) OT133G8J IRAK1_HUMAN Increases Expression [11]
UV excision repair protein RAD23 homolog B (RAD23B) OT0PGOG3 RD23B_HUMAN Increases Expression [11]
Programmed cell death protein 4 (PDCD4) OTZ6NXUX PDCD4_HUMAN Decreases Expression [11]
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) OTM3H5OA MALT1_HUMAN Increases Expression [11]
RAF proto-oncogene serine/threonine-protein kinase (RAF1) OT51LSFO RAF1_HUMAN Increases Expression [63]
Diamine acetyltransferase 1 (SAT1) OT52AU22 SAT1_HUMAN Increases Expression [63]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Increases Expression [63]
Enoyl-CoA hydratase, mitochondrial (ECHS1) OTS0593S ECHM_HUMAN Increases Expression [63]
Spermine synthase (SMS) OT8JYKNH SPSY_HUMAN Increases Expression [63]
10 kDa heat shock protein, mitochondrial (HSPE1) OT7JSZLB CH10_HUMAN Increases Expression [63]
Thymosin beta-4 (TMSB4X) OT9HPLP3 TYB4_HUMAN Increases Expression [63]
Large ribosomal subunit protein uL14 (RPL23) OTXI1YLM RL23_HUMAN Increases Expression [63]
Small ribosomal subunit protein eS28 (RPS28) OT12IES1 RS28_HUMAN Increases Expression [63]
Thymosin beta-10 (TMSB10) OTLVZ13T TYB10_HUMAN Increases Expression [63]
FXYD domain-containing ion transport regulator 3 (FXYD3) OT9PPRHE FXYD3_HUMAN Increases Expression [63]
Cocaine esterase (CES2) OTC647SQ EST2_HUMAN Increases Expression [14]
Aurora kinase A (AURKA) OTMX0HYT AURKA_HUMAN Decreases Expression [14]
Regulator of G-protein signaling 16 (RGS16) OTBKZASI RGS16_HUMAN Affects Expression [14]
Securin (PTTG1) OTIMYS4W PTTG1_HUMAN Decreases Expression [14]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Decreases Expression [14]
Epoxide hydrolase 1 (EPHX1) OTBKWQER HYEP_HUMAN Increases Expression [14]
DNA topoisomerase 2-alpha (TOP2A) OT6LPS08 TOP2A_HUMAN Decreases Expression [14]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Decreases Expression [14]
Elastin (ELN) OTFSO7PG ELN_HUMAN Affects Expression [14]
Integrin beta-4 (ITGB4) OT28UK84 ITB4_HUMAN Decreases Expression [14]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Decreases Expression [14]
NADPH:adrenodoxin oxidoreductase, mitochondrial (FDXR) OTPDCK1F ADRO_HUMAN Increases Expression [14]
Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1) OTGP6GA4 NR4A1_HUMAN Affects Expression [14]
Corticotropin-releasing factor-binding protein (CRHBP) OT9AB48G CRHBP_HUMAN Affects Expression [14]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [14]
CCN family member 2 (CCN2) OTC39NSU CCN2_HUMAN Affects Expression [14]
DNA replication licensing factor MCM4 (MCM4) OT19PNNG MCM4_HUMAN Affects Expression [14]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Decreases Expression [14]
Chitinase-3-like protein 1 (CHI3L1) OT2Z7VJH CH3L1_HUMAN Increases Expression [14]
L-dopachrome tautomerase (DCT) OTYVNTBG TYRP2_HUMAN Affects Expression [14]
Proliferation marker protein Ki-67 (MKI67) OTA8N1QI KI67_HUMAN Decreases Expression [14]
Serine/threonine-protein kinase PLK1 (PLK1) OTRZX45T PLK1_HUMAN Decreases Expression [14]
GTP-binding protein GEM (GEM) OT6SK8ZV GEM_HUMAN Affects Expression [14]
DNA-binding protein inhibitor ID-3 (ID3) OTUULW5Z ID3_HUMAN Increases Expression [14]
Regulator of G-protein signaling 1 (RGS1) OTGXJYMG RGS1_HUMAN Affects Expression [14]
Dihydropyrimidinase-related protein 3 (DPYSL3) OTINJV20 DPYL3_HUMAN Affects Expression [14]
Elongin-A (ELOA) OTOQTF5K ELOA1_HUMAN Affects Expression [14]
Squalene monooxygenase (SQLE) OT0GGRDO ERG1_HUMAN Decreases Expression [14]
Cyclin-dependent kinase 5 activator 1 (CDK5R1) OTJELWK0 CD5R1_HUMAN Affects Expression [14]
Quinone oxidoreductase PIG3 (TP53I3) OTSCM68G QORX_HUMAN Increases Expression [14]
Probable carboxypeptidase X1 (CPXM1) OTRCSQPG CPXM1_HUMAN Affects Expression [14]
Krueppel-like factor 6 (KLF6) OTQY9S7F KLF6_HUMAN Decreases Expression [14]
Epiphycan (EPYC) OTTRI5WO EPYC_HUMAN Affects Expression [14]
Collagen alpha-1(XII) chain (COL12A1) OTHLTV53 COCA1_HUMAN Decreases Expression [14]
Growth/differentiation factor 15 (GDF15) OTWQN50N GDF15_HUMAN Increases Expression [14]
Spondin-1 (SPON1) OTC06MY4 SPON1_HUMAN Affects Expression [14]
Ras-related protein Rab-21 (RAB21) OTH3WGLG RAB21_HUMAN Affects Expression [14]
Homeobox protein Hox-C11 (HOXC11) OT8NMHM6 HXC11_HUMAN Affects Expression [15]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) OTYG179K PR15A_HUMAN Increases Expression [15]
Amino acid transporter heavy chain SLC3A2 (SLC3A2) OTBR33M9 4F2_HUMAN Increases Expression [15]
Ribonucleoside-diphosphate reductase large subunit (RRM1) OTXGQOR9 RIR1_HUMAN Increases Expression [15]
Serine/arginine-rich splicing factor 11 (SRSF11) OTZSV6CZ SRS11_HUMAN Increases Expression [15]
Unconventional myosin-Ie (MYO1E) OTM9YSIZ MYO1E_HUMAN Increases Expression [15]
Cleavage stimulation factor subunit 3 (CSTF3) OT1Y7B5U CSTF3_HUMAN Increases Expression [15]
Centromere protein Q (CENPQ) OT3M6WAI CENPQ_HUMAN Increases Expression [15]
Arginine/serine-rich coiled-coil protein 2 (RSRC2) OTLE0KQM RSRC2_HUMAN Increases Expression [15]
ADP-ribosylation factor GTPase-activating protein 1 (ARFGAP1) OTM3KHIE ARFG1_HUMAN Increases Expression [15]
DNA damage-binding protein 2 (DDB2) OTO8HVVB DDB2_HUMAN Increases Expression [15]
Spermatogenesis-associated protein 25 (SPATA25) OTJMFF0A SPT25_HUMAN Increases Expression [15]
G-protein coupled receptor 35 (GPR35) OTO23NRK GPR35_HUMAN Increases Expression [15]
Regulation of nuclear pre-mRNA domain-containing protein 1B (RPRD1B) OTB41D5K RPR1B_HUMAN Increases Expression [15]
Transcription factor 19 (TCF19) OT7NKLF9 TCF19_HUMAN Increases Expression [15]
Mitogen-activated protein kinase 13 (MAPK13) OT0W9GE7 MK13_HUMAN Increases Expression [16]
Eukaryotic translation initiation factor 3 subunit H (EIF3H) OT61RBF5 EIF3H_HUMAN Increases Expression [16]
Mitotic checkpoint protein BUB3 (BUB3) OTU91HAU BUB3_HUMAN Decreases Expression [16]
Cytohesin-3 (CYTH3) OTBXAT3Z CYH3_HUMAN Decreases Expression [16]
NADH dehydrogenase 1 alpha subcomplex subunit 10, mitochondrial (NDUFA10) OTBURQ3A NDUAA_HUMAN Increases Expression [16]
GTPase KRas (KRAS) OT78QCN8 RASK_HUMAN Decreases Expression [16]
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) OT47AK4C HNRPC_HUMAN Increases Expression [16]
Histone H1.3 (H1-3) OTT7VPRB H13_HUMAN Increases Expression [16]
Cation-dependent mannose-6-phosphate receptor (M6PR) OTFEWOSB MPRD_HUMAN Increases Expression [16]
Long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADL) OTP7Y0UF ACADL_HUMAN Increases Expression [16]
Endoplasmic reticulum resident protein 29 (ERP29) OTNKANMH ERP29_HUMAN Decreases Expression [16]
Glutathione S-transferase theta-1 (GSTT1) OTRFMWBK GSTT1_HUMAN Increases Expression [16]
Large ribosomal subunit protein uL3 (RPL3) OTX6VXLB RL3_HUMAN Decreases Expression [16]
Aminomethyltransferase, mitochondrial (AMT) OTQYEWZQ GCST_HUMAN Increases Expression [16]
Translation initiation factor eIF2B subunit beta (EIF2B2) OTQQMHM1 EI2BB_HUMAN Decreases Expression [16]
Adenosine 5'-monophosphoramidase HINT1 (HINT1) OTQIR8LF HINT1_HUMAN Increases Expression [16]
D-beta-hydroxybutyrate dehydrogenase, mitochondrial (BDH1) OT62RL5P BDH_HUMAN Decreases Expression [16]
Protein phosphatase 3 catalytic subunit alpha (PPP3CA) OT58PUEN PP2BA_HUMAN Increases Expression [16]
Src substrate cortactin (CTTN) OTJRG4ES SRC8_HUMAN Decreases Expression [16]
Prostaglandin reductase 1 (PTGR1) OTMAR351 PTGR1_HUMAN Increases Expression [16]
Eukaryotic translation initiation factor 4H (EIF4H) OTGZI072 IF4H_HUMAN Increases Expression [16]
Telomeric repeat-binding factor 2 (TERF2) OTBSAS0V TERF2_HUMAN Increases Expression [16]
snRNA-activating protein complex subunit 1 (SNAPC1) OTAPN1NI SNPC1_HUMAN Decreases Expression [16]
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (NUCKS1) OTL4VJC5 NUCKS_HUMAN Decreases Expression [16]
Lipid transferase CIDEB (CIDEB) OT873IYM CIDEB_HUMAN Increases Expression [16]
Homeobox protein BarH-like 2 (BARX2) OT0R3QD3 BARX2_HUMAN Increases Expression [16]
Protocadherin alpha-5 (PCDHA5) OTHZT1GR PCDA5_HUMAN Decreases Expression [16]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) OTA675TJ GTR1_HUMAN Decreases Expression [64]
Solute carrier family 15 member 1 (SLC15A1) OT1P16B5 S15A1_HUMAN Decreases Expression [64]
Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMCHD1) OTBV52DR SMHD1_HUMAN Increases Expression [17]
Ankyrin repeat domain-containing protein 36A (ANKRD36) OT3XEYKG AN36A_HUMAN Increases Expression [17]
Pyridoxal kinase (PDXK) OT40AJ5J PDXK_HUMAN Decreases Expression [17]
Inositol monophosphatase 2 (IMPA2) OTNFB9YN IMPA2_HUMAN Increases Expression [17]
Proepiregulin (EREG) OTRM4NQY EREG_HUMAN Decreases Expression [17]
Microtubule-associated serine/threonine-protein kinase 4 (MAST4) OT3LOE2J MAST4_HUMAN Increases Expression [17]
Monocarboxylate transporter 7 (SLC16A6) OT7BIIZX MOT7_HUMAN Increases Expression [17]
Nucleoplasmin-3 (NPM3) OTIAM1A3 NPM3_HUMAN Decreases Expression [17]
Ubiquitin-like protein ATG12 (ATG12) OTJRO09Y ATG12_HUMAN Decreases Expression [17]
Fibroblast growth factor 2 (FGF2) OT7YUJ9F FGF2_HUMAN Decreases Expression [17]
Microtubule-associated protein 2 (MAP2) OT6UYT3X MTAP2_HUMAN Increases Expression [17]
Ribose-phosphate pyrophosphokinase 2 (PRPS2) OTCY1B1O PRPS2_HUMAN Decreases Expression [17]
Tissue factor (F3) OT3MSU3B TF_HUMAN Decreases Expression [17]
Folate receptor alpha (FOLR1) OT0QZ0H6 FOLR1_HUMAN Decreases Expression [17]
Calretinin (CALB2) OTSNMCG9 CALB2_HUMAN Increases Expression [17]
Signal transducer CD24 (CD24) OT7CODJ4 CD24_HUMAN Increases Expression [17]
M-phase inducer phosphatase 1 (CDC25A) OTSLKKCO MPIP1_HUMAN Decreases Expression [17]
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (MAN1A1) OT6LIGJP MA1A1_HUMAN Increases Expression [17]
Proteasome subunit beta type-10 (PSMB10) OTURUR9B PSB10_HUMAN Decreases Expression [17]
Regulator of G-protein signaling 2 (RGS2) OT0FSRW7 RGS2_HUMAN Decreases Expression [17]
Nuclear receptor-interacting protein 1 (NRIP1) OTIZOJQV NRIP1_HUMAN Decreases Expression [17]
CCN family member 3 (CCN3) OTOW5YL4 CCN3_HUMAN Increases Expression [17]
Caveolin-2 (CAV2) OT1FGRQX CAV2_HUMAN Decreases Expression [17]
ADP-ribosylation factor-like protein 4C (ARL4C) OTQ3QNNU ARL4C_HUMAN Increases Expression [17]
Transmembrane protein 33 (TMEM33) OTRG1DOY TMM33_HUMAN Decreases Expression [17]
Epiplakin (EPPK1) OT7BAU8C EPIPL_HUMAN Increases Expression [17]
Triosephosphate isomerase (TPI1) OT14KP4B TPIS_HUMAN Decreases Expression [17]
Protein jagged-1 (JAG1) OT3LGT6K JAG1_HUMAN Increases Expression [17]
High mobility group nucleosome-binding domain-containing protein 5 (HMGN5) OTUUAHVQ HMGN5_HUMAN Increases Expression [17]
Small EDRK-rich factor 2 (SERF2) OTZQDYCZ SERF2_HUMAN Decreases Expression [17]
Transcription factor SOX-4 (SOX4) OTSS40SS SOX4_HUMAN Increases Expression [17]
Proline-rich nuclear receptor coactivator 1 (PNRC1) OTQMLEE1 PNRC1_HUMAN Increases Expression [17]
S-methyl-5'-thioadenosine phosphorylase (MTAP) OTOWN2K9 MTAP_HUMAN Decreases Expression [17]
Spliceosome RNA helicase DDX39B (DDX39B) OTEVCFVU DX39B_HUMAN Increases Expression [17]
Beta-1-syntrophin (SNTB1) OTSRBECI SNTB1_HUMAN Increases Expression [17]
Transcription factor Dp-1 (TFDP1) OT6RZ7VT TFDP1_HUMAN Decreases Expression [17]
Semaphorin-3A (SEMA3A) OTQJSV7W SEM3A_HUMAN Increases Expression [17]
Uncharacterized protein KIAA0040 (KIAA0040) OT27EBY3 K0040_HUMAN Increases Expression [17]
Cyclin-G2 (CCNG2) OTII38K2 CCNG2_HUMAN Increases Expression [17]
Dual specificity protein phosphatase 6 (DUSP6) OT4H6RKW DUS6_HUMAN Increases Expression [17]
Pre-rRNA-processing protein TSR1 homolog (TSR1) OTCVZFL9 TSR1_HUMAN Decreases Expression [17]
Fibronectin type III domain-containing protein 3B (FNDC3B) OTBILGDR FND3B_HUMAN Decreases Expression [17]
Nucleolar MIF4G domain-containing protein 1 (NOM1) OTWZSJJC NOM1_HUMAN Decreases Expression [17]
Protein FAM76B (FAM76B) OT4RG5U7 FA76B_HUMAN Decreases Expression [17]
MAGUK p55 subfamily member 7 (MPP7) OT3G3HTZ MPP7_HUMAN Decreases Expression [17]
U11/U12 small nuclear ribonucleoprotein 48 kDa protein (SNRNP48) OTSR6DEJ SNR48_HUMAN Decreases Expression [17]
Parafibromin (CDC73) OT6JASZ1 CDC73_HUMAN Decreases Expression [17]
Neuroblastoma breakpoint family member 10 (NBPF10) OTGOCELY NBPFA_HUMAN Increases Expression [17]
Kelch-like protein 24 (KLHL24) OTWZSX5C KLH24_HUMAN Increases Expression [17]
Ankyrin repeat domain-containing protein 11 (ANKRD11) OTV0V70M ANR11_HUMAN Increases Expression [17]
MAM domain-containing protein 2 (MAMDC2) OT4GICNY MAMC2_HUMAN Increases Expression [17]
Coiled-coil domain-containing protein 186 (CCDC186) OTONSQAD CC186_HUMAN Increases Expression [17]
Serologically defined colon cancer antigen 8 (SDCCAG8) OTV2ZGV9 SDCG8_HUMAN Increases Expression [17]
Liprin-beta-1 (PPFIBP1) OTRA2S7B LIPB1_HUMAN Increases Expression [17]
Homeobox protein Mohawk (MKX) OT7H7Z50 MKX_HUMAN Decreases Expression [17]
Mastermind-like protein 2 (MAML2) OT1TSVAR MAML2_HUMAN Increases Expression [17]
Delta and Notch-like epidermal growth factor-related receptor (DNER) OT2GH2E5 DNER_HUMAN Increases Expression [17]
Ribosome biogenesis protein BRX1 homolog (BRIX1) OTQ5F1D1 BRX1_HUMAN Decreases Expression [17]
Tribbles homolog 2 (TRIB2) OTHSX3MX TRIB2_HUMAN Increases Expression [17]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1) OT2363Z9 T53I1_HUMAN Increases Expression [17]
Alkylated DNA repair protein alkB homolog 8 (ALKBH8) OTXN70DV ALKB8_HUMAN Decreases Expression [17]
EF-hand domain-containing protein D2 (EFHD2) OTM9VMN3 EFHD2_HUMAN Decreases Expression [17]
H/ACA ribonucleoprotein complex non-core subunit NAF1 (NAF1) OTMJKJAK NAF1_HUMAN Decreases Expression [17]
Heparan-sulfate 6-O-sulfotransferase 2 (HS6ST2) OT8A3H9Y H6ST2_HUMAN Decreases Expression [17]
Transmembrane protein 74 (TMEM74) OT3IZBM0 TMM74_HUMAN Increases Expression [17]
Small integral membrane protein 14 (SMIM14) OT47IF19 SIM14_HUMAN Increases Expression [17]
Peptide deformylase, mitochondrial (PDF) OTZ75ZK5 DEFM_HUMAN Increases Expression [17]
Synaptotagmin-like protein 2 (SYTL2) OTUIOWKL SYTL2_HUMAN Increases Expression [17]
Uncharacterized protein C14orf132 (C14ORF132) OTBVC3AO CN132_HUMAN Increases Expression [17]
Cell death regulator Aven (AVEN) OTGIN5YK AVEN_HUMAN Decreases Expression [17]
DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C) OTPL0AI1 ABC3C_HUMAN Increases Expression [17]
DNA damage-inducible transcript 4 protein (DDIT4) OTHY8SY4 DDIT4_HUMAN Increases Expression [17]
Cysteine-rich motor neuron 1 protein (CRIM1) OTTZNV6Y CRIM1_HUMAN Decreases Expression [17]
Protein DBF4 homolog A (DBF4) OTBL7JHQ DBF4A_HUMAN Decreases Expression [17]
Pleckstrin homology domain-containing family B member 1 (PLEKHB1) OTC7TNAX PKHB1_HUMAN Increases Expression [17]
Switch-associated protein 70 (SWAP70) OTPHT2QD SWP70_HUMAN Decreases Expression [17]
Carboxypeptidase A4 (CPA4) OT66MP0F CBPA4_HUMAN Decreases Expression [17]
Endoribonuclease Dicer (DICER1) OTTVSEY0 DICER_HUMAN Decreases Expression [17]
RRP15-like protein (RRP15) OTE8CQ7K RRP15_HUMAN Decreases Expression [17]
AP-4 complex subunit sigma-1 (AP4S1) OTM3QBU8 AP4S1_HUMAN Decreases Expression [17]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) OTQ4W7MT TR11B_HUMAN Increases Expression [18]
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2) OTKOZRZP PLOD2_HUMAN Decreases Expression [18]
Nuclear factor 1 B-type (NFIB) OTX94PD0 NFIB_HUMAN Decreases Expression [18]
Apoptotic protease-activating factor 1 (APAF1) OTJWIVY0 APAF_HUMAN Increases Expression [18]
Suppressor of cytokine signaling 1 (SOCS1) OTWA9KFU SOCS1_HUMAN Increases Expression [18]
Krueppel-like factor 4 (KLF4) OT4O9RQW KLF4_HUMAN Increases Expression [18]
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) OT8KME51 BUB1B_HUMAN Decreases Expression [18]
Cell division control protein 45 homolog (CDC45) OT6NNLOD CDC45_HUMAN Affects Expression [18]
Transcription factor Maf (MAF) OT1GR3IZ MAF_HUMAN Increases Expression [18]
G2/mitotic-specific cyclin-B2 (CCNB2) OTIEXTDK CCNB2_HUMAN Decreases Expression [18]
Fibrinogen silencer-binding protein (RAD54B) OTMWB2P2 FSBP_HUMAN Decreases Expression [18]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [18]
GTPase HRas (HRAS) OTWQN0DP RASH_HUMAN Increases Expression [18]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Increases Expression [18]
Thymidine kinase, cytosolic (TK1) OTY5JFM1 KITH_HUMAN Affects Expression [18]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Expression [18]
Transcriptional activator Myb (MYB) OTJH64IV MYB_HUMAN Decreases Expression [18]
Myb-related protein B (MYBL2) OTZ3JX8Q MYBB_HUMAN Increases Expression [18]
Proliferating cell nuclear antigen (PCNA) OTHZ1RIA PCNA_HUMAN Increases Expression [18]
Transcription factor JunB (JUNB) OTG2JXV5 JUNB_HUMAN Increases Expression [18]
CCAAT/enhancer-binding protein beta (CEBPB) OTM9MQIA CEBPB_HUMAN Increases Expression [18]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Increases Expression [18]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) OTVLI4DD TNAP3_HUMAN Increases Expression [18]
Insulin-like growth factor-binding protein 5 (IGFBP5) OTRE5V0C IBP5_HUMAN Decreases Expression [18]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Increases Expression [18]
Lysine-specific demethylase 5A (KDM5A) OTLYFX8A KDM5A_HUMAN Decreases Expression [18]
2'-5'-oligoadenylate synthase 2 (OAS2) OT64CCTM OAS2_HUMAN Increases Expression [18]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2) OTOB6J6R RIR2_HUMAN Decreases Expression [18]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Increases Expression [18]
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (DUT) OT0THBVA DUT_HUMAN Decreases Expression [18]
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Increases Expression [18]
DNA-binding protein inhibitor ID-1 (ID1) OTKGNZN5 ID1_HUMAN Increases Expression [18]
Protein phosphatase inhibitor 2 (PPP1R2) OTNLOUQR IPP2_HUMAN Decreases Expression [18]
Cyclin-dependent kinase 4 inhibitor C (CDKN2C) OTCLOV90 CDN2C_HUMAN Decreases Expression [18]
DNA mismatch repair protein Msh2 (MSH2) OT10H1AB MSH2_HUMAN Decreases Expression [18]
Histone deacetylase 4 (HDAC4) OTQNGD32 HDAC4_HUMAN Decreases Expression [18]
Protein S100-A10 (S100A10) OTI71243 S10AA_HUMAN Increases Expression [18]
Large ribosomal subunit protein eL37 (RPL37) OTB6SDZ1 RL37_HUMAN Decreases Expression [18]
Fanconi anemia group C protein (FANCC) OTTIDM3P FANCC_HUMAN Decreases Expression [18]
DNA-binding protein inhibitor ID-2 (ID2) OT0U1D53 ID2_HUMAN Increases Expression [18]
Transforming growth factor beta receptor type 3 (TGFBR3) OTQOOUC4 TGBR3_HUMAN Increases Expression [18]
Histone-binding protein RBBP4 (RBBP4) OTG3BT3M RBBP4_HUMAN Decreases Expression [18]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Increases Expression [18]
Ribosomal protein eS27-like (RPS27L) OTZWHU0N RS27L_HUMAN Increases Expression [18]
Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B) OTE8GBUR RIR2B_HUMAN Increases Expression [18]
Pantothenate kinase 1 (PANK1) OT2CZVRT PANK1_HUMAN Increases Expression [18]
Cullin-5 (CUL5) OTMTZD47 CUL5_HUMAN Increases Expression [18]
RNA-binding protein 14 (RBM14) OTO9GMBD RBM14_HUMAN Increases Expression [18]
Endothelial PAS domain-containing protein 1 (EPAS1) OTRE3O8U EPAS1_HUMAN Increases Expression [18]
Target of rapamycin complex 2 subunit MAPKAP1 (MAPKAP1) OTYKB9G3 SIN1_HUMAN Increases Expression [18]
E3 ubiquitin-protein ligase SMURF1 (SMURF1) OT5UIZR8 SMUF1_HUMAN Increases Expression [18]
Diablo IAP-binding mitochondrial protein (DIABLO) OTHJ9MCZ DBLOH_HUMAN Increases Expression [18]
SERTA domain-containing protein 1 (SERTAD1) OTBHKZQP SRTD1_HUMAN Increases Expression [18]
Heat shock protein beta-8 (HSPB8) OT0I83YS HSPB8_HUMAN Increases Expression [18]
F-box only protein 5 (FBXO5) OTTR957W FBX5_HUMAN Decreases Expression [18]
Pleckstrin homology-like domain family A member 3 (PHLDA3) OTXFUDO2 PHLA3_HUMAN Increases Expression [18]
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18) OTCW8HT6 TNR18_HUMAN Increases Expression [18]
Regulator of G-protein signaling 13 (RGS13) OTPAMQ18 RGS13_HUMAN Decreases Expression [19]
Pre-mRNA-processing factor 17 (CDC40) OTOYUNHN PRP17_HUMAN Increases Expression [19]
Synaptosomal-associated protein 29 (SNAP29) OTT30ZON SNP29_HUMAN Increases Expression [19]
Protein phosphatase 1 regulatory subunit 17 (PPP1R17) OT19635T PPR17_HUMAN Increases Expression [19]
RAC-beta serine/threonine-protein kinase (AKT2) OTBB632K AKT2_HUMAN Increases Expression [19]
Serpin B4 (SERPINB4) OT88LHZ8 SPB4_HUMAN Decreases Expression [19]
Cullin-4B (CUL4B) OT2QX4DO CUL4B_HUMAN Increases Expression [19]
TRAF family member-associated NF-kappa-B activator (TANK) OTZSGFIK TANK_HUMAN Increases Expression [19]
Engulfment and cell motility protein 2 (ELMO2) OTKDOC2M ELMO2_HUMAN Increases Expression [19]
Mitotic spindle assembly checkpoint protein MAD2B (MAD2L2) OT24ZO59 MD2L2_HUMAN Decreases Expression [19]
Peptidyl-prolyl cis-trans isomerase E (PPIE) OTIE5OAD PPIE_HUMAN Increases Expression [19]
Transmembrane gamma-carboxyglutamic acid protein 1 (PRRG1) OTMH6OWG TMG1_HUMAN Decreases Expression [20]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Increases Expression [20]
Protein sprouty homolog 1 (SPRY1) OT764FXI SPY1_HUMAN Increases Expression [20]
Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) OTRNDZXB HNRPQ_HUMAN Decreases Expression [20]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Increases Expression [20]
Fibrinogen gamma chain (FGG) OT5BJSEX FIBG_HUMAN Decreases Expression [20]
Plasma serine protease inhibitor (SERPINA5) OTTZXPGD IPSP_HUMAN Increases Expression [20]
Interferon alpha-inducible protein 6 (IFI6) OTWOOAM4 IFI6_HUMAN Increases Expression [20]
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) OTXOQDSG IFIT1_HUMAN Increases Expression [20]
Annexin A3 (ANXA3) OTDD8OI7 ANXA3_HUMAN Increases Expression [20]
Early growth response protein 1 (EGR1) OTCP6XGZ EGR1_HUMAN Decreases Expression [20]
Fibulin-1 (FBLN1) OT5MHHOP FBLN1_HUMAN Increases Expression [20]
Myristoylated alanine-rich C-kinase substrate (MARCKS) OT7N056G MARCS_HUMAN Decreases Expression [20]
Lysophosphatidic acid receptor 6 (LPAR6) OT4BY3W4 LPAR6_HUMAN Decreases Expression [20]
Eukaryotic translation initiation factor 5 (EIF5) OT79PQUN IF5_HUMAN Increases Expression [20]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) OTOWDUNT PTEN_HUMAN Decreases Expression [20]
Ras-related protein Rab-11A (RAB11A) OTC4FW0J RB11A_HUMAN Decreases Expression [20]
Histone H4 (H4C1) OTB71W46 H4_HUMAN Decreases Expression [20]
Metallothionein-1X (MT1X) OT9AKFVS MT1X_HUMAN Decreases Expression [20]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) OTXNGZCG MD2L1_HUMAN Decreases Expression [20]
Baculoviral IAP repeat-containing protein 2 (BIRC2) OTFXFREP BIRC2_HUMAN Increases Expression [20]
Four and a half LIM domains protein 3 (FHL3) OTMPRLZ5 FHL3_HUMAN Increases Expression [20]
PCNA-associated factor (PCLAF) OTMVIOUU PAF15_HUMAN Decreases Expression [20]
Ankyrin repeat domain-containing protein 1 (ANKRD1) OTHJ7JV9 ANKR1_HUMAN Increases Expression [20]
Adipogenesis regulatory factor (ADIRF) OTTJP8D4 ADIRF_HUMAN Increases Expression [20]
Protein mono-ADP-ribosyltransferase PARP14 (PARP14) OTFXJAKK PAR14_HUMAN Increases Expression [20]
Centrosomal protein of 55 kDa (CEP55) OTGSG2PA CEP55_HUMAN Decreases Expression [20]
ATP-dependent RNA helicase SUPV3L1, mitochondrial (SUPV3L1) OT416O2G SUV3_HUMAN Decreases Expression [20]
Membrane progestin receptor beta (PAQR8) OTGZ8W9F PAQR8_HUMAN Decreases Expression [20]
Programmed cell death 6-interacting protein (PDCD6IP) OTS8T6A7 PDC6I_HUMAN Decreases Expression [20]
BTB/POZ domain-containing protein KCTD12 (KCTD12) OTPYKT4Z KCD12_HUMAN Decreases Expression [20]
Cytoplasmic FMR1-interacting protein 2 (CYFIP2) OTCAY35T CYFP2_HUMAN Increases Expression [20]
Cell division control protein 6 homolog (CDC6) OTX93FE7 CDC6_HUMAN Decreases Expression [20]
Mini-chromosome maintenance complex-binding protein (MCMBP) OTQ6WO7A MCMBP_HUMAN Increases Expression [20]
Netrin-4 (NTN4) OTDRRMP3 NET4_HUMAN Increases Expression [20]
Serine/threonine-protein kinase Nek6 (NEK6) OT8PQSO1 NEK6_HUMAN Decreases Expression [20]
Stearoyl-CoA desaturase (SCD) OTB1073G SCD_HUMAN Decreases Expression [21]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Increases Expression [21]
Protein phosphatase 1D (PPM1D) OT8NLZ9D PPM1D_HUMAN Increases Expression [21]
TP53-regulated inhibitor of apoptosis 1 (TRIAP1) OTEAUJXN TRIA1_HUMAN Increases Expression [21]
Glutathione peroxidase 1 (GPX1) OTE2O72Q GPX1_HUMAN Increases Expression [21]
Protein S100-A2 (S100A2) OTTGHJ1H S10A2_HUMAN Increases Expression [21]
Serpin B5 (SERPINB5) OTSMXQRJ SPB5_HUMAN Increases Expression [21]
Cyclin-dependent kinase inhibitor 2A (CDKN2A) OTN0ZWAE CDN2A_HUMAN Decreases Expression [21]
Elongation factor 1-alpha 1 (EEF1A1) OT00THXS EF1A1_HUMAN Increases Expression [21]
Protein BTG2 (BTG2) OTZF6K1H BTG2_HUMAN Increases Expression [21]
Antigen peptide transporter 1 (TAP1) OTJL27PW TAP1_HUMAN Increases Expression [21]
Quinone oxidoreductase (CRYZ) OTD2F4C8 QOR_HUMAN Decreases Expression [21]
Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) OTVFQEPA IKIP_HUMAN Increases Expression [21]
DNA damage-regulated autophagy modulator protein 1 (DRAM1) OTIJTXEN DRAM1_HUMAN Increases Expression [21]
Protein ECT2 (ECT2) OTQDUCT6 ECT2_HUMAN Decreases Expression [21]
Anillin (ANLN) OTXJY54C ANLN_HUMAN Decreases Expression [21]
Serine/threonine-protein kinase PLK2 (PLK2) OTKMJXJ8 PLK2_HUMAN Increases Expression [21]
Sestrin-1 (SESN1) OTSFDZWL SESN1_HUMAN Increases Expression [21]
Proto-oncogene tyrosine-protein kinase Src (SRC) OTETYX40 SRC_HUMAN Increases Phosphorylation [65]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Increases Phosphorylation [65]
Thymidine kinase 2, mitochondrial (TK2) OTS1V4XB KITM_HUMAN Increases Expression [22]
Adenylate cyclase type 9 (ADCY9) OT1IZT5K ADCY9_HUMAN Decreases Expression [22]
DNA polymerase alpha catalytic subunit (POLA1) OT1WXFVY DPOLA_HUMAN Decreases Expression [22]
Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) OTPG0K7E IMDH2_HUMAN Increases Expression [22]
CTP synthase 1 (CTPS1) OTZ9J6ZG PYRG1_HUMAN Decreases Expression [22]
Trifunctional purine biosynthetic protein adenosine-3 (GART) OT01JWJB PUR2_HUMAN Increases Expression [22]
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) OTMZN747 PUR6_HUMAN Increases Expression [22]
Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1) OT6E2OW6 ENTP1_HUMAN Decreases Expression [22]
AMP deaminase 2 (AMPD2) OTBS30JU AMPD2_HUMAN Decreases Expression [22]
Guanylate cyclase soluble subunit beta-1 (GUCY1B1) OTSHPHVB GCYB1_HUMAN Decreases Expression [22]
5'(3')-deoxyribonucleotidase, mitochondrial (NT5M) OTJF73BA NT5M_HUMAN Increases Expression [22]
Protein shisa-9 (SHISA9) OTZI2V0J SHSA9_HUMAN Increases Expression [23]
Transmembrane protein 150C (TMEM150C) OTUNPHV7 T150C_HUMAN Decreases Expression [23]
Left-right determination factor 2 (LEFTY2) OT3RX4QF LFTY2_HUMAN Decreases Expression [23]
Fatty acid-binding protein, brain (FABP7) OTRE2H4G FABP7_HUMAN Decreases Expression [23]
Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) OTMVHF9E LGR5_HUMAN Decreases Expression [23]
Cerberus (CER1) OTTAJJ63 CER1_HUMAN Decreases Expression [23]
Urokinase-type plasminogen activator (PLAU) OTX0QGKK UROK_HUMAN Increases Expression [23]
Collagen alpha-1(II) chain (COL2A1) OT5E59C8 CO2A1_HUMAN Decreases Expression [23]
Proto-oncogene DBL (MCF2) OTB9N93T MCF2_HUMAN Increases Expression [23]
Myosin light chain 4 (MYL4) OTURFCSE MYL4_HUMAN Decreases Expression [23]
Protein Cripto (CRIPTO) OT46DZXJ TDGF1_HUMAN Decreases Expression [23]
Secretogranin-2 (SCG2) OTUHXX8U SCG2_HUMAN Increases Expression [23]
Hepatocyte growth factor (HGF) OTGHUA23 HGF_HUMAN Increases Expression [23]
Homeobox protein Hox-B3 (HOXB3) OT9UC5PE HXB3_HUMAN Decreases Expression [23]
5'-nucleotidase (NT5E) OT7J5LT6 5NTD_HUMAN Increases Expression [23]
Endothelin receptor type B (EDNRB) OTLLZV3P EDNRB_HUMAN Decreases Expression [23]
Stomatin (STOM) OTC8R6EH STOM_HUMAN Decreases Expression [23]
Metalloproteinase inhibitor 3 (TIMP3) OTDGQAD1 TIMP3_HUMAN Increases Expression [23]
Glioma pathogenesis-related protein 1 (GLIPR1) OT0FGQK7 GLIP1_HUMAN Increases Expression [23]
LIM/homeobox protein Lhx1 (LHX1) OT6WI2XS LHX1_HUMAN Decreases Expression [23]
Homeobox protein Hox-A1 (HOXA1) OTMSOJ7D HXA1_HUMAN Decreases Expression [23]
Paired mesoderm homeobox protein 1 (PRRX1) OTTZK5G8 PRRX1_HUMAN Decreases Expression [23]
Cadherin-6 (CDH6) OT81Y80S CADH6_HUMAN Decreases Expression [23]
Heart- and neural crest derivatives-expressed protein 2 (HAND2) OTCXYW4Y HAND2_HUMAN Increases Expression [23]
Protein delta homolog 1 (DLK1) OTE1VLNB DLK1_HUMAN Increases Expression [23]
POU domain, class 5, transcription factor 1 (POU5F1) OTDHHN7O PO5F1_HUMAN Decreases Expression [23]
Caveolin-1 (CAV1) OTEZUR1L CAV1_HUMAN Increases Expression [23]
Testican-1 (SPOCK1) OTLTDGK7 TICN1_HUMAN Increases Expression [23]
EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) OTZVUOOB FBLN3_HUMAN Increases Expression [23]
Protein ABHD12B (ABHD12B) OTBHGWTF AB12B_HUMAN Decreases Expression [23]
Secreted frizzled-related protein 2 (SFRP2) OT8GZ0CA SFRP2_HUMAN Decreases Expression [23]
Protein LRATD1 (LRATD1) OT65IL83 LRAT1_HUMAN Increases Expression [23]
Neuroserpin (SERPINI1) OTUJHIJW NEUS_HUMAN Increases Expression [23]
Homeobox protein CDX-2 (CDX2) OTCG4TSY CDX2_HUMAN Decreases Expression [23]
G-protein coupled receptor 87 (GPR87) OTQX45UM GPR87_HUMAN Increases Expression [23]
Homeobox protein Hox-D1 (HOXD1) OTN4V9ZF HXD1_HUMAN Decreases Expression [23]
Transcription factor SOX-17 (SOX17) OT9H4WWE SOX17_HUMAN Decreases Expression [23]
Homeobox protein NANOG (NANOG) OTUEY1FM NANOG_HUMAN Decreases Expression [23]
Tumor necrosis factor receptor superfamily member 19 (TNFRSF19) OTTVT4MB TNR19_HUMAN Decreases Expression [23]
Dynein axonemal heavy chain 2 (DNAH2) OT7J5LDI DYH2_HUMAN Decreases Expression [23]
Histone deacetylase 9 (HDAC9) OTO8O0LF HDAC9_HUMAN Increases Expression [23]
Thrombospondin type-1 domain-containing protein 7A (THSD7A) OT7249HH THS7A_HUMAN Increases Expression [23]
Nuclear factor erythroid 2-related factor 3 (NFE2L3) OT1MGXT0 NF2L3_HUMAN Increases Expression [23]
Transcription factor E2F8 (E2F8) OTQKZGFP E2F8_HUMAN Affects Expression [25]
Aquaporin-12B (AQP12B) OTNU5Z4K AQ12B_HUMAN Decreases Expression [24]
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) OTBPCU2O TR10A_HUMAN Increases Expression [66]
DNA fragmentation factor subunit alpha (DFFA) OTFPFMT8 DFFA_HUMAN Decreases Expression [24]
Forkhead box protein N3 (FOXN3) OTOJYJZP FOXN3_HUMAN Decreases Expression [26]
Butyrophilin subfamily 3 member A3 (BTN3A3) OTKMSJRA BT3A3_HUMAN Increases Expression [34]
Cytochrome c oxidase subunit NDUFA4 (NDUFA4) OTDVH3QG NDUA4_HUMAN Affects Expression [24]
Importin subunit alpha-4 (KPNA3) OTLI3TM2 IMA4_HUMAN Decreases Expression [30]
CCN family member 1 (CCN1) OTKJBEMD CCN1_HUMAN Increases Expression [67]
Pirin (PIR) OT8ALXHU PIR_HUMAN Decreases Expression [26]
Claudin-4 (CLDN4) OT9C4PZ4 CLD4_HUMAN Decreases Expression [26]
Succinate dehydrogenase cytochrome b small subunit, mitochondrial (SDHD) OTYZ8XRH DHSD_HUMAN Affects Expression [24]
Acyl carrier protein, mitochondrial (NDUFAB1) OTF906UR ACPM_HUMAN Affects Expression [24]
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT) OTZX703K CDIPT_HUMAN Affects Expression [25]
Serine/threonine-protein kinase Chk1 (CHEK1) OTTTI622 CHK1_HUMAN Increases Expression [68]
Tripeptidyl-peptidase 1 (TPP1) OT2LQ771 TPP1_HUMAN Affects Expression [25]
Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C) OTVHOL9B TR10C_HUMAN Increases Expression [69]
Ras-related protein M-Ras (MRAS) OTNCVCQW RASM_HUMAN Affects Expression [25]
Tax1-binding protein 3 (TAX1BP3) OTQ6IB4T TX1B3_HUMAN Increases Expression [30]
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) OT9RDS3H IKKB_HUMAN Decreases Expression [70]
Angiopoietin-2 (ANGPT2) OTEQK65P ANGP2_HUMAN Decreases Expression [71]
Actin-related protein 2/3 complex subunit 3 (ARPC3) OTKWVF8P ARPC3_HUMAN Decreases Expression [30]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [30]
Toll-like receptor 3 (TLR3) OT8QPYXZ TLR3_HUMAN Increases Expression [72]
Melanoma-associated antigen B2 (MAGEB2) OTAGUVU5 MAGB2_HUMAN Decreases Expression [26]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Decreases Expression [73]
ATP-dependent RNA helicase DHX15 (DHX15) OT4F98TK DHX15_HUMAN Increases Expression [25]
Prominin-1 (PROM1) OTBHV8NX PROM1_HUMAN Increases Expression [26]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Increases Expression [74]
Zinc finger protein SNAI2 (SNAI2) OT7Y8EJ2 SNAI2_HUMAN Increases Expression [27]
Protein regulator of cytokinesis 1 (PRC1) OTHD0XS0 PRC1_HUMAN Decreases Expression [75]
NADH dehydrogenase 1 subunit C1, mitochondrial (NDUFC1) OTJ5TNHB NDUC1_HUMAN Affects Expression [24]
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1) OT80DZMT BUB1_HUMAN Decreases Expression [30]
Keratin, type II cuticular Hb6 (KRT86) OT93MMAK KRT86_HUMAN Decreases Expression [26]
Aldo-keto reductase family 1 member B10 (AKR1B10) OTOA4HTH AK1BA_HUMAN Affects Expression [25]
Nuclear protein 1 (NUPR1) OT4FU8C0 NUPR1_HUMAN Affects Expression [25]
Serine protease inhibitor Kazal-type 4 (SPINK4) OTHTCW94 ISK4_HUMAN Affects Expression [25]
Cystatin-8 (CST8) OTT2FRCJ CST8_HUMAN Affects Expression [25]
Histone H2B type 1-K (H2BC12) OTQ8V0KG H2B1K_HUMAN Decreases Expression [34]
Receptor activity-modifying protein 1 (RAMP1) OT7UT2XB RAMP1_HUMAN Decreases Expression [26]
Sodium channel subunit beta-2 (SCN2B) OTFAHJ38 SCN2B_HUMAN Affects Expression [25]
Probable phospholipid-transporting ATPase IIA (ATP9A) OT328F1L ATP9A_HUMAN Decreases Expression [26]
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1) OTY9R6FZ ERN1_HUMAN Increases Expression [76]
Breast cancer anti-estrogen resistance protein 3 (BCAR3) OTPJ17M8 BCAR3_HUMAN Decreases Expression [26]
Tumor necrosis factor ligand superfamily member 13 (TNFSF13) OT90OWIO TNF13_HUMAN Increases Expression [77]
Signal recognition particle subunit SRP72 (SRP72) OTPV73W7 SRP72_HUMAN Increases Expression [25]
Cystatin-F (CST7) OTQWZUVQ CYTF_HUMAN Decreases Expression [26]
Dickkopf-related protein 1 (DKK1) OTRDLUSP DKK1_HUMAN Decreases Expression [26]
Tight junction protein ZO-3 (TJP3) OTC1K8HC ZO3_HUMAN Affects Expression [25]
Mitofusin-2 (MFN2) OTPYN8A3 MFN2_HUMAN Increases Expression [78]
NADH dehydrogenase 1 beta subcomplex subunit 2, mitochondrial (NDUFB2) OT4717TF NDUB2_HUMAN Increases Expression [24]
RCC1 and BTB domain-containing protein 2 (RCBTB2) OTECBF4R RCBT2_HUMAN Affects Expression [25]
ATP-binding cassette sub-family C member 6 (ABCC6) OTZT0LKT MRP6_HUMAN Increases Expression [26]
Phenylalanine--tRNA ligase, mitochondrial (FARS2) OTXAK6F0 SYFM_HUMAN Decreases Expression [34]
Double-stranded RNA-binding protein Staufen homolog 1 (STAU1) OTTR5311 STAU1_HUMAN Decreases Expression [30]
Mitochondrial uncoupling protein 4 (SLC25A27) OTSBOPGD UCP4_HUMAN Decreases Expression [24]
NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10) OTFLILEO NDUBA_HUMAN Affects Expression [24]
Glutathione reductase, mitochondrial (GSR) OTM2TUYM GSHR_HUMAN Decreases Activity [79]
Prothrombin (F2) OTNFSM49 THRB_HUMAN Decreases Expression [30]
Coagulation factor XII (F12) OTBFD2FU FA12_HUMAN Decreases Expression [26]
Tissue-type plasminogen activator (PLAT) OTQPDNAB TPA_HUMAN Increases Expression [34]
Thyrotropin subunit beta (TSHB) OTFDI39D TSHB_HUMAN Affects Expression [80]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Increases Expression [81]
Hemoglobin subunit epsilon (HBE1) OTJPKMX4 HBE_HUMAN Decreases Expression [26]
Keratin, type II cytoskeletal 6A (KRT6A) OT392M5T K2C6A_HUMAN Affects Expression [25]
Prelamin-A/C (LMNA) OT3SG7ZR LMNA_HUMAN Increases Cleavage [82]
Apolipoprotein C-III (APOC3) OTW3520C APOC3_HUMAN Decreases Expression [76]
Metallothionein-2 (MT2A) OTHOACHD MT2_HUMAN Decreases Expression [33]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Increases Expression [81]
Catalase (CAT) OTHEBX9R CATA_HUMAN Decreases Activity [79]
Vitamin K-dependent protein C (PROC) OTGVH484 PROC_HUMAN Decreases Activity [83]
Annexin A1 (ANXA1) OT5OFDJC ANXA1_HUMAN Decreases Expression [26]
Apolipoprotein B-100 (APOB) OTH0UOCZ APOB_HUMAN Decreases Expression [76]
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) OTBPMIMW G3P_HUMAN Affects Splicing [84]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Decreases Expression [30]
Metallothionein-1E (MT1E) OTXJKU4Y MT1E_HUMAN Increases Expression [26]
Integrin beta-2 (ITGB2) OTEKPEPR ITB2_HUMAN Decreases Expression [85]
Plasminogen activator inhibitor 2 (SERPINB2) OT72QLZB PAI2_HUMAN Increases Expression [30]
Ubiquitin-like protein ISG15 (ISG15) OT53QQ7N ISG15_HUMAN Increases Expression [34]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) OTM0GDTP IF2A_HUMAN Increases Phosphorylation [86]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Increases Expression [87]
Endothelin-1 (EDN1) OTZCACEG EDN1_HUMAN Increases Expression [88]
Keratin, type I cytoskeletal 18 (KRT18) OTVLQFIP K1C18_HUMAN Affects Expression [24]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Increases Phosphorylation [89]
Progesterone receptor (PGR) OT0FZ3QE PRGR_HUMAN Affects Expression [24]
Eukaryotic translation initiation factor 4E (EIF4E) OTDAWNLA IF4E_HUMAN Increases Expression [25]
Protein disulfide-isomerase (P4HB) OTTYNYPF PDIA1_HUMAN Decreases Expression [76]
Trypsin-2 (PRSS2) OTOMVUWL TRY2_HUMAN Affects Expression [25]
Bifunctional glutamate/proline--tRNA ligase (EPRS1) OTXK0FLB SYEP_HUMAN Decreases Expression [30]
Cathepsin B (CTSB) OTP9G5QB CATB_HUMAN Increases Cleavage [90]
DNA excision repair protein ERCC-1 (ERCC1) OTNPYQHI ERCC1_HUMAN Decreases Expression [91]
Thrombospondin-1 (THBS1) OT0ECWK3 TSP1_HUMAN Increases Expression [92]
Zinc finger protein GLI1 (GLI1) OT1BTAJO GLI1_HUMAN Decreases Expression [93]
Collagen alpha-2(IV) chain (COL4A2) OTJK1LKN CO4A2_HUMAN Decreases Expression [26]
Nuclear factor 1 C-type (NFIC) OTLMCUIB NFIC_HUMAN Increases Expression [25]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Affects Expression [25]
Keratin, type I cytoskeletal 16 (KRT16) OTGA0EQN K1C16_HUMAN Increases Expression [81]
CD63 antigen (CD63) OT2UGZA9 CD63_HUMAN Decreases Expression [85]
Retinol-binding protein 1 (RBP1) OTRP1MFC RET1_HUMAN Decreases Expression [26]
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) OTIRPN6B ROA1_HUMAN Decreases Expression [34]
Pro-cathepsin H (CTSH) OTLFL0DG CATH_HUMAN Increases Expression [26]
Cytochrome c oxidase subunit 6C (COX6C) OT3V7JE5 COX6C_HUMAN Affects Expression [24]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Expression [31]
Interferon-induced protein with tetratricopeptide repeats 2 (IFIT2) OTI4EOAR IFIT2_HUMAN Increases Expression [34]
Serum amyloid A-1 protein (SAA1) OTO2D8S0 SAA1_HUMAN Increases Expression [34]
Heat shock 70 kDa protein 1A (HSPA1A) OTKGIE76 HS71A_HUMAN Decreases Expression [26]
Small integral membrane protein 10-like protein 2A (SMIM10L2B) OT04IG2N SIL2A_HUMAN Decreases Expression [24]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [87]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [94]
Cytochrome c oxidase subunit 5B, mitochondrial (COX5B) OTDP94F3 COX5B_HUMAN Affects Expression [24]
T-cell surface glycoprotein CD8 beta chain (CD8B) OTMZ1T7J CD8B_HUMAN Decreases Expression [26]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Decreases Expression [76]
DNA topoisomerase 1 (TOP1) OT51O0CF TOP1_HUMAN Decreases Expression [30]
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (BCKDHA) OT0LHOZB ODBA_HUMAN Affects Expression [25]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Decreases Expression [26]
Interferon-induced transmembrane protein 1 (IFITM1) OTECO1G8 IFM1_HUMAN Increases Expression [34]
Platelet glycoprotein Ib beta chain (GP1BB) OTD7XNLL GP1BB_HUMAN Affects Expression [25]
Keratin, type II cytoskeletal 5 (KRT5) OTVGI9HT K2C5_HUMAN Decreases Expression [26]
Protein disulfide-isomerase A4 (PDIA4) OTVFUJ13 PDIA4_HUMAN Decreases Expression [30]
Troponin T, slow skeletal muscle (TNNT1) OT8PBOAR TNNT1_HUMAN Decreases Expression [26]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Increases Expression [27]
Aspartate--tRNA ligase, cytoplasmic (DARS1) OT0WGC2T SYDC_HUMAN Affects Expression [25]
Protein C-ets-1 (ETS1) OT4LVGDN ETS1_HUMAN Increases Expression [70]
Fos-related antigen 1 (FOSL1) OT9YTYMB FOSL1_HUMAN Affects Expression [24]
Amphiregulin (AREG) OTJFOR67 AREG_HUMAN Increases Expression [30]
Transcription factor E2-alpha (TCF3) OTW6FR32 TFE2_HUMAN Affects Expression [24]
Cytochrome c oxidase subunit 7C, mitochondrial (COX7C) OTREWSBF COX7C_HUMAN Affects Expression [24]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Phosphorylation [66]
Methylated-DNA--protein-cysteine methyltransferase (MGMT) OT40A9WH MGMT_HUMAN Decreases Expression [95]
Carboxypeptidase E (CPE) OTXNTV79 CBPE_HUMAN Increases Expression [26]
Interferon alpha/beta receptor 1 (IFNAR1) OTD4OOFK INAR1_HUMAN Increases Expression [96]
HLA class I histocompatibility antigen, alpha chain G (HLA-G) OTMLK1KN HLAG_HUMAN Increases Expression [34]
Regulator of chromosome condensation (RCC1) OT25AGMB RCC1_HUMAN Decreases Expression [30]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Increases Expression [86]
Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6) OTAFHAVI ATF6A_HUMAN Affects Expression [24]
ATP synthase-coupling factor 6, mitochondrial (ATP5PF) OTDAE8FP ATP5J_HUMAN Increases Expression [24]
Nucleolin (NCL) OTBXPKMP NUCL_HUMAN Affects Splicing [84]
Troponin I, cardiac muscle (TNNI3) OT65E12V TNNI3_HUMAN Decreases Expression [26]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) OT2D9DOV TNR1A_HUMAN Affects Expression [24]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Increases Phosphorylation [27]
Lamin-B1 (LMNB1) OT100T3P LMNB1_HUMAN Decreases Expression [24]
Hepatocyte nuclear factor 1-alpha (HNF1A) OT9DOUKL HNF1A_HUMAN Affects Expression [24]
C4b-binding protein beta chain (C4BPB) OTJ70B0K C4BPB_HUMAN Affects Expression [25]
Kit ligand (KITLG) OTB9AVQ4 SCF_HUMAN Increases Expression [88]
Lactoperoxidase (LPO) OTJ9QKX9 PERL_HUMAN Decreases Expression [97]
Cornifin-B (SPRR1B) OTXNW3P6 SPR1B_HUMAN Affects Expression [25]
Paired box protein Pax-3 (PAX3) OTN5PJZV PAX3_HUMAN Decreases Expression [29]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Decreases Expression [98]
ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) OTPOAAUW AT5F1_HUMAN Affects Expression [24]
Insulin-like growth factor-binding protein 6 (IGFBP6) OTW878VI IBP6_HUMAN Decreases Expression [26]
Cyclin-C (CCNC) OTMVK4K4 CCNC_HUMAN Decreases Expression [30]
G1/S-specific cyclin-E1 (CCNE1) OTLD7UID CCNE1_HUMAN Decreases Expression [35]
Cytochrome P450 2F1 (CYP2F1) OTY3HJH1 CP2F1_HUMAN Affects Expression [25]
DNA replication licensing factor MCM3 (MCM3) OTOOHQPM MCM3_HUMAN Decreases Expression [30]
Protein S100-P (S100P) OTJCXNJG S100P_HUMAN Decreases Expression [26]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Decreases Degradation [99]
Paired box protein Pax-6 (PAX6) OTOC9876 PAX6_HUMAN Decreases Expression [78]
Protein S100-A4 (S100A4) OTLRGFSQ S10A4_HUMAN Decreases Expression [26]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Increases Phosphorylation [100]
G0/G1 switch protein 2 (G0S2) OT8FL49L G0S2_HUMAN Increases Expression [26]
Probable global transcription activator SNF2L1 (SMARCA1) OT0Y6PTU SMCA1_HUMAN Increases Expression [26]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Increases Phosphorylation [100]
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) OTG0TTX7 CD38_HUMAN Affects Expression [25]
Tripeptidyl-peptidase 2 (TPP2) OT91OVAU TPP2_HUMAN Affects Localization [101]
Caspase-1 (CASP1) OTZ3YQFU CASP1_HUMAN Increases Cleavage [102]
Cellular retinoic acid-binding protein 1 (CRABP1) OTISDG5X RABP1_HUMAN Increases Expression [26]
ATP synthase subunit delta, mitochondrial (ATP5F1D) OTXTAG2V ATPD_HUMAN Affects Expression [24]
G1/S-specific cyclin-D2 (CCND2) OTDULQF9 CCND2_HUMAN Increases Expression [26]
G1/S-specific cyclin-D3 (CCND3) OTNKPQ22 CCND3_HUMAN Increases Expression [30]
M-phase inducer phosphatase 2 (CDC25B) OT12MSRY MPIP2_HUMAN Decreases Expression [30]
HLA class I histocompatibility antigen, alpha chain F (HLA-F) OT76CM19 HLAF_HUMAN Increases Expression [34]
Adenylosuccinate synthetase isozyme 2 (ADSS2) OTW26XXB PURA2_HUMAN Decreases Expression [30]
Neurotensin receptor type 1 (NTSR1) OTTJUTE3 NTR1_HUMAN Decreases Expression [26]
CAMPATH-1 antigen (CD52) OT02LDQN CD52_HUMAN Affects Expression [25]
Neural cell adhesion molecule L1 (L1CAM) OTNWAQ4Y L1CAM_HUMAN Decreases Expression [26]
Homeobox protein OTX2 (OTX2) OTTV05B1 OTX2_HUMAN Decreases Expression [78]
Cyclin-dependent kinases regulatory subunit 2 (CKS2) OTPTMHIV CKS2_HUMAN Decreases Expression [75]
Protein S100-A3 (S100A3) OTVIZJ2R S10A3_HUMAN Decreases Expression [26]
Heat shock 70 kDa protein 4 (HSPA4) OT5HR0AR HSP74_HUMAN Decreases Expression [26]
5-hydroxytryptamine receptor 7 (HTR7) OT44DEWB 5HT7R_HUMAN Affects Expression [25]
Profilin-2 (PFN2) OT5SSSA7 PROF2_HUMAN Increases Expression [26]
Radixin (RDX) OTNSYUN6 RADI_HUMAN Affects Expression [25]
Cornifin-A (SPRR1A) OTJMI34A SPR1A_HUMAN Increases Expression [25]
Homeobox protein MSX-2 (MSX2) OT1WDKE1 MSX2_HUMAN Decreases Expression [26]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [103]
Sterol regulatory element-binding protein 1 (SREBF1) OTWBRPAI SRBP1_HUMAN Affects Expression [24]
17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2) OT3K7HY5 DHB2_HUMAN Affects Expression [25]
Amiloride-sensitive sodium channel subunit alpha (SCNN1A) OTE2KVZV SCNNA_HUMAN Decreases Expression [26]
Peroxisome proliferator-activated receptor gamma (PPARG) OTHMARHO PPARG_HUMAN Decreases Expression [26]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Decreases Expression [104]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [105]
Hepatocyte nuclear factor 4-alpha (HNF4A) OTY1TOAB HNF4A_HUMAN Affects Expression [24]
Neuroblastoma suppressor of tumorigenicity 1 (NBL1) OTT37U4O NBL1_HUMAN Decreases Expression [30]
Signal transducer and activator of transcription 1-alpha/beta (STAT1) OTLMBUZ6 STAT1_HUMAN Increases Expression [24]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Affects Expression [25]
Serine/threonine-protein kinase mTOR (MTOR) OTHH8KU7 MTOR_HUMAN Decreases Expression [97]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Expression [106]
Caspase-2 (CASP2) OTUDYSPP CASP2_HUMAN Decreases Expression [24]
Melanoma-associated antigen 2 (MAGEA2) OTQ0YOTY MAGA2_HUMAN Decreases Expression [26]
Melanoma-associated antigen 6 (MAGEA6) OTI8S0O2 MAGA6_HUMAN Decreases Expression [26]
Melanoma-associated antigen 12 (MAGEA12) OT8ULELL MAGAC_HUMAN Decreases Expression [26]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Decreases Expression [35]
Retinaldehyde dehydrogenase 3 (ALDH1A3) OT1C9NKQ AL1A3_HUMAN Decreases Expression [26]
Galectin-7 (LGALS7) OTMSVI7R LEG7_HUMAN Decreases Expression [26]
Iron-responsive element-binding protein 2 (IREB2) OT747D24 IREB2_HUMAN Increases Expression [25]
Interferon alpha/beta receptor 2 (IFNAR2) OTBIRNIJ INAR2_HUMAN Increases Expression [34]
Sodium/hydrogen exchanger 3 (SLC9A3) OTZ7PFVT SL9A3_HUMAN Decreases Expression [24]
Caspase-4 (CASP4) OTVQTV1L CASP4_HUMAN Increases Expression [26]
Casein kinase I isoform epsilon (CSNK1E) OTF0UXX6 KC1E_HUMAN Affects Expression [25]
Tuberin (TSC2) OT47LWI9 TSC2_HUMAN Increases Expression [25]
NADH dehydrogenase flavoprotein 1, mitochondrial (NDUFV1) OTEVK4WW NDUV1_HUMAN Affects Expression [24]
Ketohexokinase (KHK) OT153922 KHK_HUMAN Increases Expression [26]
Homeobox protein MOX-1 (MEOX1) OTJEMT2D MEOX1_HUMAN Increases Expression [29]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Increases Expression [107]
Amiloride-sensitive sodium channel subunit beta (SCNN1B) OT61QQTL SCNNB_HUMAN Affects Expression [25]
Serine/threonine-protein kinase Nek4 (NEK4) OTOB8366 NEK4_HUMAN Decreases Expression [30]
Cyclin-G1 (CCNG1) OT17IA9L CCNG1_HUMAN Decreases Expression [30]
Rho-related GTP-binding protein RhoN (RND2) OT98M6UI RND2_HUMAN Increases Expression [34]
Importin subunit alpha-1 (KPNA2) OTU7FOE6 IMA1_HUMAN Decreases Expression [75]
Rho GDP-dissociation inhibitor 2 (ARHGDIB) OT9PD6CS GDIR2_HUMAN Affects Expression [24]
Hexokinase-2 (HK2) OTC0GCQO HXK2_HUMAN Decreases Expression [108]
Ephrin-B2 (EFNB2) OT0DCUOM EFNB2_HUMAN Decreases Expression [26]
Death-associated protein kinase 1 (DAPK1) OTNCNUCO DAPK1_HUMAN Increases Expression [70]
LIM domain kinase 1 (LIMK1) OTFZ8MZ0 LIMK1_HUMAN Affects Expression [24]
Monocarboxylate transporter 1 (SLC16A1) OTW1UTZ7 MOT1_HUMAN Decreases Expression [30]
Heat shock-related 70 kDa protein 2 (HSPA2) OTSDET7B HSP72_HUMAN Increases Expression [34]
Microsomal triglyceride transfer protein large subunit (MTTP) OTNUVSDT MTP_HUMAN Decreases Expression [76]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Increases Expression [24]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Decreases Expression [109]
Caspase-6 (CASP6) OTXLD3EC CASP6_HUMAN Affects Expression [24]
Forkhead box protein G1 (FOXG1) OTAW57J4 FOXG1_HUMAN Decreases Expression [78]
NADH dehydrogenase flavoprotein 3, mitochondrial (NDUFV3) OTSCYB9P NDUV3_HUMAN Increases Expression [24]
NADH dehydrogenase 1 alpha subcomplex subunit 6 (NDUFA6) OTEOIIOL NDUA6_HUMAN Affects Expression [24]
Claudin-2 (CLDN2) OTRF3D6Y CLD2_HUMAN Decreases Expression [27]
Sestrin-2 (SESN2) OT889IXY SESN2_HUMAN Increases Expression [110]
Forkhead box protein L2 (FOXL2) OTFRQUYL FOXL2_HUMAN Increases Expression [24]
Ribose-phosphate pyrophosphokinase 1 (PRPS1) OTN3A6CN PRPS1_HUMAN Increases Expression [25]
Ras-related protein Rab-8A (RAB8A) OTPB54Y3 RAB8A_HUMAN Decreases Expression [30]
C-X-C chemokine receptor type 4 (CXCR4) OTUFSBX2 CXCR4_HUMAN Affects Expression [25]
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PPP2CB) OT24GMCM PP2AB_HUMAN Increases Expression [30]
Small ribosomal subunit protein eS26 (RPS26) OTBYTA6A RS26_HUMAN Affects Expression [25]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (GNB2) OT3JPRCQ GBB2_HUMAN Decreases Expression [30]
Actin, gamma-enteric smooth muscle (ACTG2) OTRDWUO0 ACTH_HUMAN Decreases Expression [30]
Hemoglobin subunit beta (HBB) OT514IKQ HBB_HUMAN Affects Splicing [84]
E3 ubiquitin-protein ligase RNF4 (RNF4) OTCMXQRE RNF4_HUMAN Decreases Expression [30]
Cyclin-A1 (CCNA1) OTX4HD45 CCNA1_HUMAN Affects Expression [109]
Interferon-induced 35 kDa protein (IFI35) OTV9RZ53 IN35_HUMAN Increases Expression [34]
Transcriptional activator protein Pur-alpha (PURA) OT975ELW PURA_HUMAN Affects Expression [25]
Interferon regulatory factor 9 (IRF9) OTK4MYQJ IRF9_HUMAN Increases Expression [34]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Increases Expression [105]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Decreases Expression [24]
Exosome complex component 10 (EXOSC10) OTH8Z0AL EXOSX_HUMAN Increases Metabolism [111]
Transgelin (TAGLN) OTAEZ0KP TAGL_HUMAN Decreases Expression [26]
Myocyte-specific enhancer factor 2B (MEF2B) OT880SE6 MEF2B_HUMAN Affects Expression [25]
A-kinase anchor protein 12 (AKAP12) OTCVRDDX AKA12_HUMAN Affects Expression [25]
Lamin-B2 (LMNB2) OTXRDUOS LMNB2_HUMAN Decreases Expression [24]
Antigen peptide transporter 2 (TAP2) OTWSYFI7 TAP2_HUMAN Increases Expression [112]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Decreases Expression [113]
Keratin, type I cytoskeletal 17 (KRT17) OT6Y1DPK K1C17_HUMAN Affects Expression [25]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Affects Expression [25]
Protein kinase C zeta type (PRKCZ) OTN2FE42 KPCZ_HUMAN Affects Expression [25]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Increases Expression [114]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [73]
Forkhead box protein M1 (FOXM1) OT5887KR FOXM1_HUMAN Decreases Expression [24]
Neuroblast differentiation-associated protein AHNAK (AHNAK) OT6KH1WG AHNK_HUMAN Decreases Expression [26]
Mesoderm posterior protein 2 (MESP2) OT7H4LYA MESP2_HUMAN Increases Expression [29]
Sterol regulatory element-binding protein 2 (SREBF2) OTBXUNPL SRBP2_HUMAN Decreases Expression [24]
Transcription factor 15 (TCF15) OTA6UCWC TCF15_HUMAN Increases Expression [29]
Heat shock protein 75 kDa, mitochondrial (TRAP1) OTNG0L8J TRAP1_HUMAN Affects Expression [24]
TNF receptor-associated factor 2 (TRAF2) OT1MEZZN TRAF2_HUMAN Decreases Expression [99]
Forkhead box protein C1 (FOXC1) OTOWZGYO FOXC1_HUMAN Affects Expression [25]
Vesicle transport protein SEC20 (BNIP1) OT7USYCY SEC20_HUMAN Increases Expression [32]
Baculoviral IAP repeat-containing protein 1 (NAIP) OTLA925F BIRC1_HUMAN Decreases Expression [34]
RE1-silencing transcription factor (REST) OTLL92LQ REST_HUMAN Affects Expression [25]
FAS-associated death domain protein (FADD) OTV7GFHH FADD_HUMAN Decreases Expression [24]
Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) OTS3FVTY M3K1_HUMAN Affects Expression [24]
28 kDa heat- and acid-stable phosphoprotein (PDAP1) OTJSWMOD HAP28_HUMAN Decreases Expression [30]
Aquaporin-6 (AQP6) OTXS6UYY AQP6_HUMAN Decreases Expression [24]
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) OTC41R1E RIPK1_HUMAN Increases Expression [24]
Neurogenic differentiation factor 1 (NEUROD1) OTZQ7QJ2 NDF1_HUMAN Affects Expression [25]
Protein patched homolog 1 (PTCH1) OTMG07H5 PTC1_HUMAN Decreases Expression [93]
CD166 antigen (ALCAM) OTCO4LP7 CD166_HUMAN Decreases Expression [26]
Spectrin alpha chain, non-erythrocytic 1 (SPTAN1) OT6VY3A3 SPTN1_HUMAN Increases Expression [24]
Low-density lipoprotein receptor-related protein 8 (LRP8) OTZ71YV2 LRP8_HUMAN Decreases Expression [34]
Transcription factor E2F2 (E2F2) OTO75RM7 E2F2_HUMAN Decreases Expression [24]
Fas-activated serine/threonine kinase (FASTK) OTTHFZMP FASTK_HUMAN Decreases Expression [24]
Guanidinoacetate N-methyltransferase (GAMT) OTVC87ES GAMT_HUMAN Increases Expression [26]
Transcription factor HES-1 (HES1) OT8P19W2 HES1_HUMAN Increases Activity [115]
Indian hedgehog protein (IHH) OT1DWGXC IHH_HUMAN Decreases Expression [116]
Transmembrane protein 187 (TMEM187) OTOE4G8T TM187_HUMAN Decreases Expression [24]
Pumilio homolog 1 (PUM1) OTTMWP8L PUM1_HUMAN Affects Expression [25]
Major vault protein (MVP) OTJGHJRB MVP_HUMAN Increases Expression [117]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Decreases Expression [109]
Kinesin-like protein KIF14 (KIF14) OTXHT4JM KIF14_HUMAN Decreases Expression [24]
Angiopoietin-1 (ANGPT1) OTVZ1NG3 ANGP1_HUMAN Increases Expression [71]
Sonic hedgehog protein (SHH) OTOG2BXF SHH_HUMAN Decreases Expression [93]
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD) OTBOSJHO TRADD_HUMAN Affects Expression [24]
Heat shock protein beta-2 (HSPB2) OTS01646 HSPB2_HUMAN Increases Phosphorylation [92]
Transcription factor E2F4 (E2F4) OTB3JFH4 E2F4_HUMAN Decreases Expression [24]
BDNF/NT-3 growth factors receptor (NTRK2) OTD557PU NTRK2_HUMAN Decreases Expression [26]
Survival motor neuron protein (SMN2) OT54RLO1 SMN_HUMAN Decreases Expression [34]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Decreases Expression [118]
Kinesin-like protein KIF26B (KIF26B) OTVHWIKR KI26B_HUMAN Decreases Expression [24]
Protein BEAN1 (BEAN1) OT0WLH27 BEAN1_HUMAN Increases Expression [26]
Filamin A-interacting protein 1-like (FILIP1L) OTPY8IMS FIL1L_HUMAN Increases Expression [26]
Borealin (CDCA8) OT17D55D BOREA_HUMAN Decreases Expression [75]
Early estrogen-induced gene 1 protein (EEIG1) OT2BMEAE EEIG1_HUMAN Affects Expression [25]
Transcription initiation factor TFIID subunit 3 (TAF3) OTVMULE9 TAF3_HUMAN Affects Expression [25]
GRAM domain-containing protein 4 (GRAMD4) OT1HXEPM GRAM4_HUMAN Increases Expression [119]
Heme transporter HRG1 (SLC48A1) OTPFHZLO HRG1_HUMAN Affects Expression [25]
Proline/serine-rich coiled-coil protein 1 (PSRC1) OT7MDJMN PSRC1_HUMAN Decreases Expression [75]
Protein aurora borealis (BORA) OTV2ZPKP BORA_HUMAN Decreases Expression [75]
Teashirt homolog 1 (TSHZ1) OTYQ9ECW TSH1_HUMAN Increases Expression [25]
Protein MCM10 homolog (MCM10) OTV0O3JN MCM10_HUMAN Affects Expression [25]
Oligodendrocyte transcription factor 3 (OLIG3) OTU8XLAF OLIG3_HUMAN Decreases Expression [29]
Protein lifeguard 1 (GRINA) OTMC1O66 LFG1_HUMAN Affects Expression [25]
Cyclin-J-like protein (CCNJL) OTU0SRTC CCNJL_HUMAN Affects Expression [25]
Mitofusin-1 (MFN1) OTCBXQZF MFN1_HUMAN Increases Expression [78]
Protein NOXP20 (FAM114A1) OT0208Y4 NXP20_HUMAN Affects Expression [25]
Extracellular serine/threonine protein kinase FAM20C (FAM20C) OTW5YZ7X FA20C_HUMAN Affects Expression [25]
Serine/arginine repetitive matrix protein 1 (SRRM1) OTAY2IP6 SRRM1_HUMAN Decreases Expression [30]
Ankyrin repeat domain-containing protein 36B (ANKRD36B) OT3MW415 AN36B_HUMAN Affects Expression [25]
Metallothionein-1M (MT1M) OTVT8PLU MT1M_HUMAN Increases Expression [26]
Integral membrane protein GPR137C (GPR137C) OTMEB9QG G137C_HUMAN Affects Expression [25]
Fibrinogen C domain-containing protein 1 (FIBCD1) OTSVT07B FBCD1_HUMAN Decreases Expression [24]
tRNA-uridine aminocarboxypropyltransferase 1 (DTWD1) OT95QT6P DTWD1_HUMAN Increases Expression [32]
ER membrane protein complex subunit 1 (EMC1) OTYAH4LX EMC1_HUMAN Affects Expression [25]
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) OTBIN5IP SCPDL_HUMAN Increases Expression [34]
Minor histocompatibility antigen H13 (HM13) OTGEO1LP HM13_HUMAN Affects Expression [25]
Serine/threonine-protein kinase Nek9 (NEK9) OT4VQCL5 NEK9_HUMAN Decreases Expression [30]
Grainyhead-like protein 3 homolog (GRHL3) OT1V4ZEH GRHL3_HUMAN Affects Expression [25]
Transmembrane protein 40 (TMEM40) OTSJKKNA TMM40_HUMAN Affects Expression [25]
Lipase member H (LIPH) OTRGYLKL LIPH_HUMAN Decreases Expression [30]
MAP kinase-activating death domain protein (MADD) OTUFYVGG MADD_HUMAN Affects Expression [24]
E3 ubiquitin-protein ligase MYLIP (MYLIP) OTL0PFGV MYLIP_HUMAN Affects Expression [25]
Serine protease HTRA1 (HTRA1) OTR8ACBF HTRA1_HUMAN Increases Expression [26]
Symplekin (SYMPK) OTYAUDXV SYMPK_HUMAN Decreases Expression [30]
Caspase-10 (CASP10) OTE6J88E CASPA_HUMAN Increases Expression [24]
Kallikrein-6 (KLK6) OTIEA234 KLK6_HUMAN Decreases Expression [26]
Solute carrier organic anion transporter family member 2A1 (SLCO2A1) OT3062CA SO2A1_HUMAN Affects Expression [25]
Major histocompatibility complex class I-related gene protein (MR1) OTZU3XX7 HMR1_HUMAN Increases Expression [34]
Optineurin (OPTN) OT2UXWH9 OPTN_HUMAN Increases Expression [34]
Sororin (CDCA5) OTZLCQ5U CDCA5_HUMAN Increases Expression [30]
THO complex subunit 1 (THOC1) OTVABJ4Z THOC1_HUMAN Decreases Expression [30]
Chronophin (PDXP) OTZ7GN95 PLPP_HUMAN Decreases Expression [30]
Cytochrome c oxidase assembly protein COX14 (COX14) OTQ378WN COX14_HUMAN Affects Expression [24]
Retina and anterior neural fold homeobox protein 2 (RAX2) OT1HD6CF RAX2_HUMAN Affects Expression [25]
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (AGAP3) OT8C6PKL AGAP3_HUMAN Decreases Expression [30]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Increases Expression [120]
Serine/threonine-protein kinase Nek1 (NEK1) OTBUCUW6 NEK1_HUMAN Decreases Expression [30]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Affects Expression [25]
Transcription factor ATOH8 (ATOH8) OT7SY3BN ATOH8_HUMAN Affects Expression [25]
Pre-mRNA-splicing factor 18 (PRPF18) OTX4VZ4R PRP18_HUMAN Decreases Expression [34]
MyoD family inhibitor (MDFI) OTIA6YUG MDFI_HUMAN Decreases Expression [26]
Noelin (OLFM1) OTOYPEWW NOE1_HUMAN Increases Expression [26]
Protein smoothened (SMO) OTXXE208 SMO_HUMAN Decreases Expression [93]
Retinoic acid receptor responder protein 2 (RARRES2) OT1BJE8K RARR2_HUMAN Decreases Expression [30]
NADH dehydrogenase 1 alpha subcomplex assembly factor 3 (NDUFAF3) OT4MCB6W NDUF3_HUMAN Decreases Expression [24]
Multiple myeloma tumor-associated protein 2 (C1ORF35) OTK6PUYF MMTA2_HUMAN Affects Expression [25]
Mitochondrial adenyl nucleotide antiporter SLC25A23 (SLC25A23) OTG0B7RM SCMC3_HUMAN Affects Expression [25]
Histone-lysine N-methyltransferase SETD5 (SETD5) OTRPAVEO SETD5_HUMAN Affects Expression [25]
Hyaluronan and proteoglycan link protein 2 (HAPLN2) OT0G3KEQ HPLN2_HUMAN Affects Expression [25]
PR domain zinc finger protein 14 (PRDM14) OTWZKY4L PRD14_HUMAN Affects Expression [24]
Neurogenin-2 (NEUROG2) OTAEMIGT NGN2_HUMAN Decreases Expression [29]
Kallikrein-15 (KLK15) OT7BVG17 KLK15_HUMAN Affects Expression [25]
Serine/threonine-protein kinase PLK3 (PLK3) OT19CT2Z PLK3_HUMAN Increases Expression [105]
Complex I assembly factor ACAD9, mitochondrial (ACAD9) OT4HITJ6 ACAD9_HUMAN Decreases Expression [24]
2-oxoglutarate and iron-dependent oxygenase JMJD4 (JMJD4) OTYZGH63 JMJD4_HUMAN Decreases Expression [24]
ATP-binding cassette sub-family B member 6 (ABCB6) OTPGZFES ABCB6_HUMAN Decreases Expression [112]
StAR-related lipid transfer protein 7, mitochondrial (STARD7) OTDUZ296 STAR7_HUMAN Affects Expression [25]
Muscleblind-like protein 1 (MBNL1) OTOV7J85 MBNL1_HUMAN Decreases Expression [30]
Mitogen-activated protein kinase kinase kinase 20 (MAP3K20) OT0ALMEG M3K20_HUMAN Affects Expression [25]
NF-kappa-B inhibitor-interacting Ras-like protein 1 (NKIRAS1) OTWETJTL KBRS1_HUMAN Affects Expression [25]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) OT0DZGY4 E2AK3_HUMAN Increases Expression [76]
Myoferlin (MYOF) OTRFC3IJ MYOF_HUMAN Decreases Expression [26]
Programmed cell death 1 ligand 1 (CD274) OTJ0VFDL PD1L1_HUMAN Increases Expression [121]
NADH dehydrogenase 1 alpha subcomplex assembly factor 4 (NDUFAF4) OTWJ5B9M NDUF4_HUMAN Affects Expression [24]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (HMG20B) OTY94WRA HM20B_HUMAN Decreases Expression [30]
MyoD family inhibitor domain-containing protein (MDFIC) OTSRYBWZ MDFIC_HUMAN Affects Expression [25]
Ribosome-binding protein 1 (RRBP1) OT4ZTPTM RRBP1_HUMAN Decreases Expression [26]
Small proline-rich protein 3 (SPRR3) OTN9QJKG SPRR3_HUMAN Affects Expression [25]
Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D) OTOSRDJT TR10D_HUMAN Increases Expression [69]
Dickkopf-related protein 4 (DKK4) OTWCCVF6 DKK4_HUMAN Increases Expression [25]
DNA repair protein REV1 (REV1) OTHIKICX REV1_HUMAN Affects Expression [25]
Hydroxyproline dehydrogenase (PRODH2) OTHO2TO0 HYPDH_HUMAN Decreases Expression [26]
FK506-binding protein-like (FKBPL) OTR9ND6K FKBPL_HUMAN Increases Expression [106]
Suppressor of fused homolog (SUFU) OT0IRYG1 SUFU_HUMAN Decreases Expression [93]
Probable G-protein coupled receptor 132 (GPR132) OTJ5WHHX GP132_HUMAN Increases Expression [25]
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) OTNONPMB GLCNE_HUMAN Decreases Expression [26]
C-type lectin domain family 11 member A (CLEC11A) OT9KBH7C CLC11_HUMAN Decreases Expression [26]
DNA replication complex GINS protein PSF2 (GINS2) OT974IYI PSF2_HUMAN Affects Expression [25]
R3H domain-containing protein 2 (R3HDM2) OTMJ3S6J R3HD2_HUMAN Affects Expression [25]
Complex I intermediate-associated protein 30, mitochondrial (NDUFAF1) OTYK9JU6 CIA30_HUMAN Increases Expression [24]
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (SAMHD1) OTBCIBC7 SAMH1_HUMAN Affects Expression [25]
Angiopoietin-related protein 3 (ANGPTL3) OTCD5Z9W ANGL3_HUMAN Decreases Expression [76]
Origin recognition complex subunit 6 (ORC6) OTKQN3KP ORC6_HUMAN Increases Expression [25]
NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) OTO3WI7S NDUB9_HUMAN Affects Expression [24]
Soluble TNF receptor II (CRMB1) OT06I7G2 CRMB_CAMPM Increases ADR [122]
Mitochondrial pyruvate carrier 2 (MPC2) OT0GHXGG MPC2_HUMAN Affects Response To Substance [37]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Decreases Response To Substance [123]
Tumor protein p73 (TP73) OT0LUO47 P73_HUMAN Affects Response To Substance [124]
Nucleoside diphosphate kinase A (NME1) OT0NELQ1 NDKA_HUMAN Affects Response To Substance [38]
Four and a half LIM domains protein 2 (FHL2) OT0OAYWT FHL2_HUMAN Affects Response To Substance [37]
Tripartite motif-containing protein 2 (TRIM2) OT0V1YVC TRIM2_HUMAN Affects Response To Substance [37]
Neuropilin and tolloid-like protein 2 (NETO2) OT0YAMC0 NETO2_HUMAN Affects Response To Substance [37]
Sperm protein associated with the nucleus on the X chromosome C (SPANXC) OT1033B9 SPNXC_HUMAN Affects Response To Substance [37]
Acid ceramidase (ASAH1) OT1DNGXL ASAH1_HUMAN Affects Response To Substance [37]
Solute carrier family 35 member F5 (SLC35F5) OT1FX2QO S35F5_HUMAN Affects Response To Substance [125]
Replication factor C subunit 3 (RFC3) OT1MS7AO RFC3_HUMAN Affects Response To Substance [38]
Amyloid beta precursor protein binding family B member 2 (APBB2) OT1VD51B APBB2_HUMAN Affects Response To Substance [37]
Carboxypeptidase D (CPD) OT2CS64Y CBPD_HUMAN Affects Response To Substance [37]
Uncharacterized protein C11orf24 (C11ORF24) OT2DOJ6E CK024_HUMAN Affects Response To Substance [37]
La-related protein 4B (LARP4B) OT2HI0QE LAR4B_HUMAN Affects Response To Substance [37]
Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3) OT2HZK5M GTR3_HUMAN Affects Response To Substance [37]
Nucleoside diphosphate kinase, mitochondrial (NME4) OT2JTT42 NDKM_HUMAN Affects Response To Substance [37]
Chromobox protein homolog 1 (CBX1) OT2L4XZX CBX1_HUMAN Affects Response To Substance [37]
Kelch-like protein 7 (KLHL7) OT2OF1O8 KLHL7_HUMAN Affects Response To Substance [37]
LIM and SH3 domain protein 1 (LASP1) OT2QIDCL LASP1_HUMAN Affects Response To Substance [37]
Protein transport protein Sec31A (SEC31A) OT2U42AC SC31A_HUMAN Affects Response To Substance [37]
Protein-tyrosine sulfotransferase 2 (TPST2) OT2XKFCE TPST2_HUMAN Affects Response To Substance [37]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Decreases Response To Substance [126]
Protein FAM171A1 (FAM171A1) OT33BHEP F1711_HUMAN Affects Response To Substance [37]
Very long chain fatty acid elongase 5 (ELOVL5) OT375W1Z ELOV5_HUMAN Affects Response To Substance [37]
Ubiquitin carboxyl-terminal hydrolase CYLD (CYLD) OT37FKH0 CYLD_HUMAN Increases Response To Substance [127]
Angiogenin (ANG) OT3ECS6P ANGI_HUMAN Affects Response To Substance [37]
Focal adhesion kinase 1 (PTK2) OT3Q1JDY FAK1_HUMAN Decreases Response To Substance [128]
Hypermethylated in cancer 2 protein (HIC2) OT3VP1D9 HIC2_HUMAN Affects Response To Substance [37]
Sorcin (SRI) OT4R3EAC SORCN_HUMAN Decreases Response To Substance [129]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) OT4SO7J4 BNIP3_HUMAN Affects Response To Substance [130]
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (OXCT1) OT536PE7 SCOT1_HUMAN Affects Response To Substance [37]
DNA repair nuclease/redox regulator APEX1 (APEX1) OT53OI14 APEX1_HUMAN Increases Response To Substance [131]
Breast carcinoma-amplified sequence 4 (BCAS4) OT596N5E BCAS4_HUMAN Affects Response To Substance [37]
Myosin phosphatase Rho-interacting protein (MPRIP) OT5FV5NS MPRIP_HUMAN Affects Response To Substance [37]
Collagen alpha-2(V) chain (COL5A2) OT5VOSQE CO5A2_HUMAN Affects Response To Substance [37]
Tumor necrosis factor receptor superfamily member 5 (CD40) OT5YU2XB TNR5_HUMAN Decreases Response To Substance [132]
Mitochondrial enolase superfamily member 1 (ENOSF1) OT65D3ZK ENOF1_HUMAN Decreases Response To Substance [133]
Macrophage colony-stimulating factor 1 (CSF1) OT68M7RD CSF1_HUMAN Affects Response To Substance [37]
Myosin regulatory light polypeptide 9 (MYL9) OT6B22JB MYL9_HUMAN Affects Response To Substance [37]
Glutamate--cysteine ligase regulatory subunit (GCLM) OT6CP234 GSH0_HUMAN Affects Response To Substance [37]
Melanoma-associated antigen D1 (MAGED1) OT6EOLFC MAGD1_HUMAN Affects Response To Substance [38]
DNA replication licensing factor MCM7 (MCM7) OT6FXC6K MCM7_HUMAN Affects Response To Substance [38]
Electron transfer flavoprotein subunit beta (ETFB) OT6Q6FBD ETFB_HUMAN Affects Response To Substance [38]
Opioid growth factor receptor-like protein 1 (OGFRL1) OT6QGBYE OGRL1_HUMAN Affects Response To Substance [37]
DNA topoisomerase 2-binding protein 1 (TOPBP1) OT6UPZPD TOPB1_HUMAN Affects Response To Substance [38]
Transforming protein RhoA (RHOA) OT6YOJ9N RHOA_HUMAN Decreases Response To Substance [134]
GTP-binding protein 4 (GTPBP4) OT6ZHAWC GTPB4_HUMAN Affects Response To Substance [37]
Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) OT714BUO AL3A2_HUMAN Affects Response To Substance [37]
Cytosolic acyl coenzyme A thioester hydrolase (ACOT7) OT7C68YV BACH_HUMAN Affects Response To Substance [38]
Polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3) OT7M67WT GALT3_HUMAN Affects Response To Substance [37]
Pro-adrenomedullin (ADM) OT7T0TA4 ADML_HUMAN Affects Response To Substance [37]
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) OT7Y43A1 PP1A_HUMAN Affects Response To Substance [37]
CDKN2A-interacting protein (CDKN2AIP) OT80RRQJ CARF_HUMAN Affects Response To Substance [37]
Cbp/p300-interacting transactivator 2 (CITED2) OT812TV7 CITE2_HUMAN Affects Response To Substance [38]
Peptidyl-prolyl cis-trans isomerase FKBP1B (FKBP1B) OT8CMPB2 FKB1B_HUMAN Affects Response To Substance [37]
Mortality factor 4-like protein 2 (MORF4L2) OT8OI3EC MO4L2_HUMAN Decreases Response To Substance [135]
Putative hydrolase DDAH2 (DDAH2) OT8Q40G2 DDAH2_HUMAN Affects Response To Substance [37]
Pre-B-cell leukemia transcription factor 3 (PBX3) OT8WMVM4 PBX3_HUMAN Affects Response To Substance [37]
Intersectin-1 (ITSN1) OT8YF3S5 ITSN1_HUMAN Affects Response To Substance [37]
Frizzled-2 (FZD2) OT952ML1 FZD2_HUMAN Affects Response To Substance [37]
Galectin-3-binding protein (LGALS3BP) OT9AGQKH LG3BP_HUMAN Affects Response To Substance [37]
L-lactate dehydrogenase B chain (LDHB) OT9B1CT3 LDHB_HUMAN Affects Response To Substance [37]
Transcription factor MafF (MAFF) OT9B7MX0 MAFF_HUMAN Affects Response To Substance [37]
Epsilon-sarcoglycan (SGCE) OT9F17JB SGCE_HUMAN Affects Response To Substance [37]
Carbohydrate sulfotransferase 7 (CHST7) OT9HCUST CHST7_HUMAN Affects Response To Substance [37]
Adapter molecule crk (CRK) OT9Q5YSN CRK_HUMAN Affects Response To Substance [37]
Dysbindin domain-containing protein 2 (DBNDD2) OT9RI580 DBND2_HUMAN Affects Response To Substance [37]
Lanosterol synthase (LSS) OT9W2SFH LSS_HUMAN Affects Response To Substance [37]
Perilipin-3 (PLIN3) OT9ZA7MR PLIN3_HUMAN Affects Response To Substance [37]
Tissue factor pathway inhibitor (TFPI) OTA0FX16 TFPI1_HUMAN Affects Response To Substance [37]
Apolipoprotein C-I (APOC1) OTA58CED APOC1_HUMAN Affects Response To Substance [37]
Ribonuclease 4 (RNASE4) OTA5SZLC RNAS4_HUMAN Affects Response To Substance [37]
SEC14-like protein 1 (SEC14L1) OTA75FET S14L1_HUMAN Affects Response To Substance [37]
DNA polymerase epsilon subunit 2 (POLE2) OTAC9V6L DPOE2_HUMAN Affects Response To Substance [37]
Integrin alpha-V (ITGAV) OTAM7JTR ITAV_HUMAN Affects Response To Substance [37]
Receptor-type tyrosine-protein phosphatase kappa (PTPRK) OTAP5AT3 PTPRK_HUMAN Affects Response To Substance [37]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Decreases Response To Substance [136]
Collagen alpha-3(VI) chain (COL6A3) OTAS6R6I CO6A3_HUMAN Affects Response To Substance [37]
Cyclin-dependent kinase inhibitor 1C (CDKN1C) OTASTJ3Q CDN1C_HUMAN Affects Response To Substance [130]
Lanosterol 14-alpha demethylase (CYP51A1) OTAYHG9C CP51A_HUMAN Affects Response To Substance [37]
Sterol O-acyltransferase 1 (SOAT1) OTB4Y5RJ SOAT1_HUMAN Affects Response To Substance [37]
Ras-related protein R-Ras (RRAS) OTBBF28C RRAS_HUMAN Affects Response To Substance [37]
G1/S-specific cyclin-E2 (CCNE2) OTBBUKQQ CCNE2_HUMAN Affects Response To Substance [130]
Cochlin (COCH) OTBEHD89 COCH_HUMAN Affects Response To Substance [37]
Solute carrier family 2, facilitated glucose transporter member 14 (SLC2A14) OTBFIOVY GTR14_HUMAN Affects Response To Substance [37]
Protein transport protein Sec23A (SEC23A) OTBRNIJ3 SC23A_HUMAN Affects Response To Substance [37]
Alpha-galactosidase A (GLA) OTBSR6DT AGAL_HUMAN Affects Response To Substance [37]
Regenerating islet-derived protein 4 (REG4) OTBWIKOA REG4_HUMAN Decreases Response To Substance [137]
Transmembrane protein 184B (TMEM184B) OTBZY7E9 T184B_HUMAN Affects Response To Substance [37]
Transforming growth factor beta-2 proprotein (TGFB2) OTC0TXEP TGFB2_HUMAN Affects Response To Substance [37]
Adenylyl cyclase-associated protein 2 (CAP2) OTC1WFNO CAP2_HUMAN Affects Response To Substance [37]
RNA-binding protein 5 (RBM5) OTCBWHHV RBM5_HUMAN Affects Response To Substance [38]
Neuropilin-1 (NRP1) OTCGULYV NRP1_HUMAN Decreases Response To Substance [138]
Baculoviral IAP repeat-containing protein 6 (BIRC6) OTCQJAB0 BIRC6_HUMAN Decreases Response To Substance [139]
Probable cytosolic iron-sulfur protein assembly protein CIAO1 (CIAO1) OTCU8PFI CIAO1_HUMAN Affects Response To Substance [38]
Aldehyde dehydrogenase 1A1 (ALDH1A1) OTCUWZKB AL1A1_HUMAN Affects Response To Substance [37]
Adhesion G protein-coupled receptor L2 (ADGRL2) OTCXD2YR AGRL2_HUMAN Affects Response To Substance [37]
Large ribosomal subunit protein eL24 (RPL24) OTCY9DEB RL24_HUMAN Affects Response To Substance [38]
Tropomyosin alpha-1 chain (TPM1) OTD73X6R TPM1_HUMAN Affects Response To Substance [37]
Protein timeless homolog (TIMELESS) OTD8DCBJ TIM_HUMAN Affects Response To Substance [38]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Increases Response To Substance [135]
Gamma-adducin (ADD3) OTDRSHAZ ADDG_HUMAN Affects Response To Substance [37]
Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) OTDS2EAR TNR1B_HUMAN Affects Response To Substance [125]
DNA polymerase subunit gamma-1 (POLG) OTDUCT04 DPOG1_HUMAN Affects Response To Substance [38]
EGF-like repeat and discoidin I-like domain-containing protein 3 (EDIL3) OTDVVNS0 EDIL3_HUMAN Affects Response To Substance [37]
Cytosolic phospholipase A2 (PLA2G4A) OTE70SOT PA24A_HUMAN Affects Response To Substance [37]
Alternative prion protein (PRNP) OTE85L1Q APRIO_HUMAN Decreases Response To Substance [140]
Very-long-chain (HACD1) OTEC7EP7 HACD1_HUMAN Affects Response To Substance [37]
DNA ligase 1 (LIG1) OTEEQS43 DNLI1_HUMAN Affects Response To Substance [38]
H(+)/Cl(-) exchange transporter 3 (CLCN3) OTEEXNMU CLCN3_HUMAN Affects Response To Substance [37]
Maternal embryonic leucine zipper kinase (MELK) OTEY2UQA MELK_HUMAN Affects Response To Substance [38]
Proteolipid protein 2 (PLP2) OTEZ4LOV PLP2_HUMAN Affects Response To Substance [37]
Paraneoplastic antigen Ma2 (PNMA2) OTF5YBQG PNMA2_HUMAN Affects Response To Substance [37]
Mitogen-activated protein kinase 7 (MAPK7) OTF7H7L7 MK07_HUMAN Decreases Response To Substance [141]
Kelch-like ECH-associated protein 1 (KEAP1) OTFHOD0C KEAP1_HUMAN Affects Response To Substance [142]
Annexin A2 (ANXA2) OTFNS0CC ANXA2_HUMAN Decreases Response To Substance [63]
E3 ubiquitin-protein ligase NEDD4 (NEDD4) OTFPXLXT NEDD4_HUMAN Affects Response To Substance [37]
SOSS complex subunit B2 (NABP1) OTFTNFHW SOSB2_HUMAN Increases ADR [143]
Centromere protein X (CENPX) OTG1RAKJ CENPX_HUMAN Affects Response To Substance [37]
Protein AF1q (MLLT11) OTG5RVHC AF1Q_HUMAN Affects Response To Substance [37]
DNA mismatch repair protein Mlh1 (MLH1) OTG5XDD8 MLH1_HUMAN Increases Response To Substance [144]
Lymphocyte antigen 6 complex locus protein G6d (LY6G6D) OTG75QOC LY66D_HUMAN Affects Response To Substance [37]
Regulator of G-protein signaling 4 (RGS4) OTG94HHL RGS4_HUMAN Affects Response To Substance [37]
TRIO and F-actin-binding protein (TRIOBP) OTGB5WHC TARA_HUMAN Affects Response To Substance [37]
Tubulin-specific chaperone E (TBCE) OTGBSTKS TBCE_HUMAN Affects Response To Substance [37]
Leucine-rich repeat transmembrane protein FLRT2 (FLRT2) OTGD8TID FLRT2_HUMAN Affects Response To Substance [37]
DNA replication licensing factor MCM2 (MCM2) OTGGORIQ MCM2_HUMAN Affects Response To Substance [38]
Fibroblast growth factor 7 (FGF7) OTGK6ANL FGF7_HUMAN Decreases Response To Substance [145]
Isopentenyl-diphosphate Delta-isomerase 1 (IDI1) OTGM06VJ IDI1_HUMAN Affects Response To Substance [37]
Melanoma-associated antigen 4 (MAGEA4) OTGP9SD0 MAGA4_HUMAN Affects Response To Substance [37]
Phospholipid scramblase 1 (PLSCR1) OTGY9B5T PLS1_HUMAN Affects Response To Substance [37]
Partitioning defective 3 homolog (PARD3) OTH5BPLO PARD3_HUMAN Affects Response To Substance [37]
Flavin reductase (BLVRB) OTHCFN2C BLVRB_HUMAN Affects Response To Substance [37]
Heat shock protein beta-1 (HSPB1) OTHFZ8ED HSPB1_HUMAN Decreases Response To Substance [146]
Potassium voltage-gated channel subfamily A member 5 (KCNA5) OTHI2N71 KCNA5_HUMAN Increases Response To Substance [147]
Translationally-controlled tumor protein (TPT1) OTHMTRJU TCTP_HUMAN Decreases Response To Substance [126]
Forkhead box protein O3 (FOXO3) OTHXQG4P FOXO3_HUMAN Affects Response To Substance [130]
Dystonin (DST) OTHZBM4X DYST_HUMAN Affects Response To Substance [37]
FYVE, RhoGEF and PH domain-containing protein 6 (FGD6) OTI0T62C FGD6_HUMAN Affects Response To Substance [37]
Protein S100-A11 (S100A11) OTI57KDN S10AB_HUMAN Increases Response To Substance [148]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) OTI862QH CPT1A_HUMAN Affects Response To Substance [38]
Laminin subunit gamma-1 (LAMC1) OTIG527N LAMC1_HUMAN Affects Response To Substance [37]
Baculoviral IAP repeat-containing protein 7 (BIRC7) OTITCGHB BIRC7_HUMAN Decreases Response To Substance [149]
Kinesin-like protein KIF2C (KIF2C) OTJ8G3NP KIF2C_HUMAN Affects Response To Substance [38]
Replication factor C subunit 2 (RFC2) OTJ9N6BD RFC2_HUMAN Affects Response To Substance [38]
Retrotransposon Gag-like protein 8C (RTL8C) OTJA37NU RTL8C_HUMAN Affects Response To Substance [37]
Cyclin-F (CCNF) OTJFVU43 CCNF_HUMAN Affects Response To Substance [130]
Heat shock cognate 71 kDa protein (HSPA8) OTJI2RCI HSP7C_HUMAN Affects Response To Substance [37]
Rhomboid-related protein 2 (RHBDL2) OTJPJ8N6 RHBL2_HUMAN Affects Response To Substance [37]
Unconventional myosin-VI (MYO6) OTJQYRC7 MYO6_HUMAN Affects Response To Substance [37]
Endothelin-1 receptor (EDNRA) OTK9T5O3 EDNRA_HUMAN Affects Response To Substance [150]
Serine/threonine-protein kinase 38 (STK38) OTKMYCYR STK38_HUMAN Affects Response To Substance [37]
Starch-binding domain-containing protein 1 (STBD1) OTKPS9AM STBD1_HUMAN Affects Response To Substance [37]
Enoyl-CoA hydratase domain-containing protein 3, mitochondrial (ECHDC3) OTKU2RMC ECHD3_HUMAN Affects Response To Substance [37]
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (MGAT2) OTKXMSM7 MGAT2_HUMAN Affects Response To Substance [37]
Calcium-binding tyrosine phosphorylation-regulated protein (CABYR) OTKYMT99 CABYR_HUMAN Affects Response To Substance [37]
EF-hand domain-containing protein D1 (EFHD1) OTL5INE4 EFHD1_HUMAN Affects Response To Substance [37]
Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B) OTL9I7LO GA45B_HUMAN Decreases Response To Substance [151]
Sorting nexin-6 (SNX6) OTLKQYJU SNX6_HUMAN Affects Response To Substance [37]
PDZ and LIM domain protein 5 (PDLIM5) OTLQVV22 PDLI5_HUMAN Affects Response To Substance [37]
Tyrosine-protein kinase Fyn (FYN) OTLSLVZS FYN_HUMAN Affects Response To Substance [37]
Separin (ESPL1) OTMGEVOK ESPL1_HUMAN Affects Response To Substance [38]
Sperm protein associated with the nucleus on the X chromosome A (SPANXA1) OTMK3QIS SPNXA_HUMAN Affects Response To Substance [37]
Pleckstrin homology domain-containing family O member 1 (PLEKHO1) OTMVUQ9W PKHO1_HUMAN Affects Response To Substance [37]
Ubiquitin-conjugating enzyme E2 R1 (CDC34) OTNBK390 UB2R1_HUMAN Affects Response To Substance [37]
Protein ENTREP3 (ENTREP3) OTNJB3FP EREP3_HUMAN Affects Response To Substance [37]
HMG box transcription factor BBX (BBX) OTNQ3QUC BBX_HUMAN Affects Response To Substance [37]
Melanoma-associated antigen D4 (MAGED4B) OTO37U7W MAGD4_HUMAN Affects Response To Substance [37]
Purine nucleoside phosphorylase (PNP) OTO5NIJ2 PNPH_HUMAN Affects Response To Substance [38]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Decreases Response To Substance [152]
Galactoside alpha-(1,2)-fucosyltransferase 1 (FUT1) OTODG57A FUT1_HUMAN Affects Response To Substance [153]
Succinate dehydrogenase flavoprotein subunit, mitochondrial (SDHA) OTOJ8QFF SDHA_HUMAN Affects Response To Substance [38]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Decreases Response To Substance [154]
Copper homeostasis protein cutC homolog (CUTC) OTOVHLU9 CUTC_HUMAN Affects Response To Substance [37]
Phosphatidylserine decarboxylase proenzyme, mitochondrial (PISD) OTP9COQT PISD_HUMAN Affects Response To Substance [38]
Ras-related protein Rab-20 (RAB20) OTP9OOVS RAB20_HUMAN Affects Response To Substance [37]
MHC class I polypeptide-related sequence A (MICA) OTPEIEAR MICA_HUMAN Affects Response To Substance [37]
Tensin-3 (TNS3) OTPG2D8Z TENS3_HUMAN Affects Response To Substance [37]
Neurotensin/neuromedin N (NTS) OTPGDNQS NEUT_HUMAN Affects Response To Substance [37]
Na(+)/citrate cotransporter (SLC13A5) OTPH1TA7 S13A5_HUMAN Decreases Response To Substance [155]
Interferon alpha-1/13 (IFNA1) OTPMKY0L IFNA1_HUMAN Increases Abundance [10]
SPARC (SPARC) OTPN90H0 SPRC_HUMAN Increases Response To Substance [156]
M-phase inducer phosphatase 3 (CDC25C) OTPQI71S MPIP3_HUMAN Affects Response To Substance [38]
Protein C-mannosyl-transferase DPY19L1 (DPY19L1) OTPULBDX D19L1_HUMAN Affects Response To Substance [37]
Transcription factor SOX-18 (SOX18) OTPUMHWA SOX18_HUMAN Affects Response To Substance [37]
Copper-transporting ATPase 2 (ATP7B) OTPWLNCO ATP7B_HUMAN Increases Response To Substance [135]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Affects Response To Substance [37]
Centromere protein U (CENPU) OTQ4TZRS CENPU_HUMAN Affects Response To Substance [38]
Adhesion G-protein coupled receptor G1 (ADGRG1) OTQBB8NT AGRG1_HUMAN Affects Response To Substance [37]
Angiopoietin-related protein 4 (ANGPTL4) OTQL5SPX ANGL4_HUMAN Affects Response To Substance [37]
Serine-protein kinase ATM (ATM) OTQVOHLT ATM_HUMAN Decreases Response To Substance [157]
E3 ubiquitin-protein ligase RNF34 (RNF34) OTQY58LU RNF34_HUMAN Decreases Response To Substance [158]
Transforming growth factor-beta-induced protein ig-h3 (TGFBI) OTR443C5 BGH3_HUMAN Affects Response To Substance [37]
Kelch-like protein 9 (KLHL9) OTRGEG3Z KLHL9_HUMAN Affects Response To Substance [37]
LIM domain kinase 2 (LIMK2) OTRJD7VZ LIMK2_HUMAN Affects Response To Substance [37]
Large ribosomal subunit protein eL6 (RPL6) OTRU71O4 RL6_HUMAN Decreases Response To Substance [159]
Perilipin-2 (PLIN2) OTRXJ9UN PLIN2_HUMAN Affects Response To Substance [37]
MHC class I polypeptide-related sequence B (MICB) OTS2DVDW MICB_HUMAN Affects Response To Substance [37]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) OTSBQR6D PLCG1_HUMAN Decreases Response To Substance [160]
Thymosin beta-15A (TMSB15A) OTSBWCES TB15A_HUMAN Affects Response To Substance [130]
Protein phosphatase 1 regulatory subunit 1B (PPP1R1B) OTSIJMQ9 PPR1B_HUMAN Increases Response To Substance [161]
Formin-binding protein 1 (FNBP1) OTSJ5KKA FNBP1_HUMAN Affects Response To Substance [37]
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) OTSMGKXQ EBP_HUMAN Affects Response To Substance [38]
Interleukin-27 receptor subunit alpha (IL27RA) OTSQBAKI I27RA_HUMAN Affects Response To Substance [37]
Rhotekin (RTKN) OTSS8XR6 RTKN_HUMAN Decreases Response To Substance [162]
Procollagen C-endopeptidase enhancer 2 (PCOLCE2) OTSUEQZ1 PCOC2_HUMAN Affects Response To Substance [37]
Collagen alpha-1(III) chain (COL3A1) OTT1EMLM CO3A1_HUMAN Affects Response To Substance [37]
Cdc42 effector protein 1 (CDC42EP1) OTT525WA BORG5_HUMAN Affects Response To Substance [37]
Gap junction alpha-1 protein (GJA1) OTT94MKL CXA1_HUMAN Affects Response To Substance [37]
Nucleophosmin (NPM1) OTTBYYT0 NPM_HUMAN Decreases Response To Substance [163]
Selenide, water dikinase 2 (SEPHS2) OTTFXROR SPS2_HUMAN Affects Response To Substance [37]
DNA polymerase alpha subunit B (POLA2) OTTWQ73N DPOA2_HUMAN Affects Response To Substance [38]
EH domain-containing protein 2 (EHD2) OTTX391J EHD2_HUMAN Affects Response To Substance [37]
Protein enabled homolog (ENAH) OTU49OK5 ENAH_HUMAN Affects Response To Substance [37]
Creatine kinase B-type (CKB) OTUCKOTT KCRB_HUMAN Affects Response To Substance [37]
Phytanoyl-CoA dioxygenase, peroxisomal (PHYH) OTUG4BWA PAHX_HUMAN Affects Response To Substance [37]
Leupaxin (LPXN) OTUNV3CK LPXN_HUMAN Affects Response To Substance [38]
AT-rich interactive domain-containing protein 5B (ARID5B) OTUQ4CQY ARI5B_HUMAN Affects Response To Substance [37]
Max-interacting protein 1 (MXI1) OTUQ9E0D MXI1_HUMAN Affects Response To Substance [37]
Cysteine and glycine-rich protein 1 (CSRP1) OTUS7RM2 CSRP1_HUMAN Affects Response To Substance [37]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) OTUYHB84 MLP3B_HUMAN Affects Response To Substance [38]
Acyl-CoA (FADS1) OTUYOYHX FADS1_HUMAN Affects Response To Substance [37]
Histone deacetylase 2 (HDAC2) OTUYVFKN HDAC2_HUMAN Increases Response To Substance [157]
Nucleolysin TIAR (TIAL1) OTV2KFZH TIAR_HUMAN Affects Response To Substance [38]
Lymphocyte antigen 6 complex locus protein G6c (LY6G6C) OTV7F59X LY66C_HUMAN Affects Response To Substance [37]
ATP-binding cassette sub-family C member 11 (ABCC11) OTVHL7OR MRP8_HUMAN Decreases Response To Substance [164]
Megakaryocyte and platelet inhibitory receptor G6b (MPIG6B) OTVNKQWA G6B_HUMAN Affects Response To Substance [37]
GTP-binding protein Rit1 (RIT1) OTVNOGOH RIT1_HUMAN Affects Response To Substance [37]
Abasic site processing protein HMCES (HMCES) OTVRDL6U HMCES_HUMAN Affects Response To Substance [38]
BAG family molecular chaperone regulator 3 (BAG3) OTVXYUDQ BAG3_HUMAN Affects Response To Substance [37]
Folylpolyglutamate synthase, mitochondrial (FPGS) OTW3F1ZE FOLC_HUMAN Increases Response To Substance [165]
Fanconi anemia group I protein (FANCI) OTW8E3SC FANCI_HUMAN Affects Response To Substance [38]
Retrotransposon-derived protein PEG10 (PEG10) OTWD2278 PEG10_HUMAN Affects Response To Substance [37]
Periostin (POSTN) OTWP62UA POSTN_HUMAN Decreases Response To Substance [166]
Acyl-coenzyme A thioesterase 13 (ACOT13) OTWRUST1 ACO13_HUMAN Affects Response To Substance [37]
DNA primase small subunit (PRIM1) OTWWP8Y6 PRI1_HUMAN Affects Response To Substance [38]
Amyloid-beta A4 precursor protein-binding family A member 2 (APBA2) OTXD8ID1 APBA2_HUMAN Affects Response To Substance [37]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Affects Response To Substance [37]
Interferon gamma (IFNG) OTXG9JM7 IFNG_HUMAN Increases Abundance [10]
Peptidyl-prolyl cis-trans isomerase FKBP11 (FKBP11) OTY2GC67 FKB11_HUMAN Affects Response To Substance [37]
Adhesion G-protein coupled receptor G6 (ADGRG6) OTY2UBXO AGRG6_HUMAN Affects Response To Substance [37]
Class E basic helix-loop-helix protein 41 (BHLHE41) OTY9GJ1Y BHE41_HUMAN Affects Response To Substance [37]
Serine/threonine-protein kinase TAO3 (TAOK3) OTYBATSH TAOK3_HUMAN Affects Response To Substance [38]
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) OTYEJAGZ GPT_HUMAN Affects Response To Substance [37]
Glia-derived nexin (SERPINE2) OTYF5340 GDN_HUMAN Increases ADR [143]
Chloride intracellular channel protein 1 (CLIC1) OTYLFWNG CLIC1_HUMAN Affects Response To Substance [37]
Interferon beta (IFNB1) OTYQGUB5 IFNB_HUMAN Increases Response To Substance [167]
Galectin-3 (LGALS3) OTYQT0ZI LEG3_HUMAN Decreases Response To Substance [168]
ADP-ribosylation factor 3 (ARF3) OTYYQX85 ARF3_HUMAN Affects Response To Substance [38]
Selenide, water dikinase 1 (SEPHS1) OTZ19I59 SPS1_HUMAN Affects Response To Substance [37]
Glutathione S-transferase A4 (GSTA4) OTZ1USIA GSTA4_HUMAN Affects Response To Substance [37]
Thiosulfate sulfurtransferase (TST) OTZ4F5LK THTR_HUMAN Affects Response To Substance [38]
Erythropoietin (EPO) OTZ90CN4 EPO_HUMAN Increases Response To Substance [169]
Fermitin family homolog 2 (FERMT2) OTZNPWWX FERM2_HUMAN Affects Response To Substance [37]
Pro-neuregulin-1, membrane-bound isoform (NRG1) OTZO6F1X NRG1_HUMAN Affects Response To Substance [37]
Latexin (LXN) OTZQ2M6Y LXN_HUMAN Affects Response To Substance [37]
Multidrug and toxin extrusion protein 1 (SLC47A1) OTZX0U5Q S47A1_HUMAN Affects Response To Substance [37]
------------------------------------------------------------------------------------
⏷ Show the Full List of 1026 DOT(s)
Indication(s) of Gemcitabine
Disease Entry ICD 11 Status REF
Anterior urethra cancer N.A. Approved [6]
Biliary tract cancer 2C17 Approved [6]
Carcinoma 2A00-2F9Z Approved [6]
Cervical cancer 2C77.0 Approved [6]
Cholangiocarcinoma 2C12.10 Approved [6]
Fallopian tube neoplasm N.A. Approved [6]
Gallbladder carcinoma N.A. Approved [6]
Leiomyosarcoma 2B58 Approved [6]
Leukemia N.A. Approved [6]
Lung cancer 2C25.0 Approved [6]
MALT lymphoma N.A. Approved [6]
Nodal marginal zone lymphoma 2A85.0 Approved [6]
Non-small-cell lung cancer 2C25 Approved [7]
Ovarian disorder N.A. Approved [6]
Ovarian neoplasm N.A. Approved [6]
Pancreatic adenocarcinoma N.A. Approved [6]
Pancreatic ductal carcinoma 2C10.0 Approved [6]
Pancreatic tumour 2C10 Approved [6]
Posterior urethra cancer N.A. Approved [6]
Recurrent adult burkitt lymphoma 2A85.6 Approved [6]
Solid tumour/cancer 2A00-2F9Z Approved [8]
Splenic marginal zone lymphoma N.A. Approved [6]
Urethral cancer 2C93 Approved [6]
Urinary bladder neoplasm N.A. Approved [6]
Middle East Respiratory Syndrome (MERS) 1D64 Preclinical [9]
Severe acute respiratory syndrome (SARS) 1D65 Preclinical [9]
Colon cancer 2B90.Z Investigative [6]
Gemcitabine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Ribonucleoside-diphosphate reductase M2 (RRM2) TTBWDI0 RIR2_HUMAN Modulator [175]
------------------------------------------------------------------------------------
Gemcitabine Interacts with 3 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [176]
Multidrug resistance-associated protein 5 (ABCC5) DTYVM24 MRP5_HUMAN Substrate [177]
Concentrative nucleoside transporter 1 (SLC28A1) DT0EQPW S28A1_HUMAN Substrate [178]
------------------------------------------------------------------------------------
Gemcitabine Interacts with 5 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytidine aminohydrolase (CDA) DEKEDRC CDD_HUMAN Metabolism [179]
Uridine/cytidine monophosphate kinase (UMPK) DEMPH4I KCY_HUMAN Metabolism [180]
Cytidine deaminase (cdd) DETX3A5 CDD_ECOLI Metabolism [181]
Cytidine deaminase (cdd) DEFVABT CDD_KLEP7 Metabolism [181]
Cytidine deaminase (cdd) DEYILK4 E0TLJ6_MYCHH Metabolism [182]
------------------------------------------------------------------------------------
Gemcitabine Interacts with 244 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytidine deaminase (CDA) OT3HXP6N CDD_HUMAN Affects Response To Substance [173]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Decreases Expression [183]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2) OTOB6J6R RIR2_HUMAN Affects Response To Substance [174]
Ribonucleoside-diphosphate reductase large subunit (RRM1) OTXGQOR9 RIR1_HUMAN Affects Response To Substance [174]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Increases Expression [184]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Decreases Expression [185]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [186]
NF-kappa-B inhibitor epsilon (NFKBIE) OTLAYEL9 IKBE_HUMAN Affects Expression [20]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) OTQ4W7MT TR11B_HUMAN Increases Expression [20]
Stearoyl-CoA desaturase (SCD) OTB1073G SCD_HUMAN Increases Expression [20]
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2) OT5I4Y9K PLCB_HUMAN Decreases Expression [20]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Increases Expression [20]
E3 ubiquitin-protein ligase Praja-2 (PJA2) OT45TMC4 PJA2_HUMAN Increases Expression [20]
Interleukin-1 receptor-associated kinase-like 2 (IRAK2) OT6Y1QZN IRAK2_HUMAN Increases Expression [20]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Increases Expression [20]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L) OTJKOMXE BNI3L_HUMAN Increases Expression [20]
Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) OTRNDZXB HNRPQ_HUMAN Decreases Expression [20]
Melanoma-associated antigen C1 (MAGEC1) OTHMFHH8 MAGC1_HUMAN Increases Expression [20]
Liprin-alpha-4 (PPFIA4) OTWXG0DO LIPA4_HUMAN Increases Expression [20]
Transcription factor Maf (MAF) OT1GR3IZ MAF_HUMAN Increases Expression [20]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) OTYG179K PR15A_HUMAN Increases Expression [20]
Krueppel-like factor 8 (KLF8) OTUC5CDB KLF8_HUMAN Increases Expression [20]
Urokinase-type plasminogen activator (PLAU) OTX0QGKK UROK_HUMAN Increases Expression [20]
Fibrinogen gamma chain (FGG) OT5BJSEX FIBG_HUMAN Affects Expression [20]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Increases Expression [20]
Keratin, type II cytoskeletal 8 (KRT8) OTTM4X11 K2C8_HUMAN Decreases Expression [20]
Growth-regulated alpha protein (CXCL1) OT3WCTZV GROA_HUMAN Increases Expression [20]
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) OTXOQDSG IFIT1_HUMAN Increases Expression [20]
Transcriptional activator Myb (MYB) OTJH64IV MYB_HUMAN Increases Expression [20]
Osteopontin (SPP1) OTJGC23Y OSTP_HUMAN Increases Expression [20]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Increases Expression [20]
Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3) OT2HZK5M GTR3_HUMAN Increases Expression [20]
Creatine kinase B-type (CKB) OTUCKOTT KCRB_HUMAN Decreases Expression [20]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Increases Expression [20]
Homeobox protein Hox-B2 (HOXB2) OTTD6HMV HXB2_HUMAN Increases Expression [20]
Fos-related antigen 2 (FOSL2) OT3MT9HJ FOSL2_HUMAN Decreases Expression [20]
Methylated-DNA--protein-cysteine methyltransferase (MGMT) OT40A9WH MGMT_HUMAN Decreases Expression [20]
CCAAT/enhancer-binding protein beta (CEBPB) OTM9MQIA CEBPB_HUMAN Increases Expression [20]
Early growth response protein 1 (EGR1) OTCP6XGZ EGR1_HUMAN Increases Expression [20]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Increases Expression [20]
C-X-C motif chemokine 2 (CXCL2) OTEJCYMY CXCL2_HUMAN Increases Expression [20]
C-X-C motif chemokine 3 (CXCL3) OTSL94KH CXCL3_HUMAN Increases Expression [20]
Endothelin-2 (EDN2) OTQ7RCPI EDN2_HUMAN Decreases Expression [20]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) OTVLI4DD TNAP3_HUMAN Increases Expression [20]
Diamine acetyltransferase 1 (SAT1) OT52AU22 SAT1_HUMAN Increases Expression [20]
Prostaglandin G/H synthase 1 (PTGS1) OTHCRLEC PGH1_HUMAN Decreases Expression [20]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Decreases Expression [20]
Tumor necrosis factor receptor superfamily member 5 (CD40) OT5YU2XB TNR5_HUMAN Decreases Expression [20]
Myristoylated alanine-rich C-kinase substrate (MARCKS) OT7N056G MARCS_HUMAN Increases Expression [20]
Protein EVI2B (EVI2B) OT98X1OE EVI2B_HUMAN Decreases Expression [20]
Heat shock 70 kDa protein 1-like (HSPA1L) OTC2V1K6 HS71L_HUMAN Decreases Expression [20]
Glutaredoxin-1 (GLRX) OT0QHTAR GLRX1_HUMAN Increases Expression [20]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [20]
Nicotinamide N-methyltransferase (NNMT) OTFM38GU NNMT_HUMAN Increases Expression [20]
B-cell lymphoma 6 protein (BCL6) OTQAWWO1 BCL6_HUMAN Increases Expression [20]
Regulator of G-protein signaling 2 (RGS2) OT0FSRW7 RGS2_HUMAN Increases Expression [20]
Leukemia inhibitory factor receptor (LIFR) OT36W9O5 LIFR_HUMAN Increases Expression [20]
Melanoma-associated antigen 10 (MAGEA10) OTI4KPYB MAGAA_HUMAN Decreases Expression [20]
Lysophosphatidic acid receptor 6 (LPAR6) OT4BY3W4 LPAR6_HUMAN Decreases Expression [20]
Ras GTPase-activating-like protein IQGAP1 (IQGAP1) OTZRWTGA IQGA1_HUMAN Increases Expression [20]
Retinaldehyde dehydrogenase 3 (ALDH1A3) OT1C9NKQ AL1A3_HUMAN Increases Expression [20]
Max-interacting protein 1 (MXI1) OTUQ9E0D MXI1_HUMAN Increases Expression [20]
ETS translocation variant 1 (ETV1) OT6PMJIK ETV1_HUMAN Increases Expression [20]
Glypican-3 (GPC3) OTWS8WSW GPC3_HUMAN Increases Expression [20]
Transcription initiation factor IIA subunit 1 (GTF2A1) OTWW4PN0 TF2AA_HUMAN Affects Expression [20]
Growth arrest-specific protein 1 (GAS1) OTKJXG52 GAS1_HUMAN Decreases Expression [20]
Puromycin-sensitive aminopeptidase (NPEPPS) OTMENFXR PSA_HUMAN Decreases Expression [20]
Methionine--tRNA ligase, cytoplasmic (MARS1) OTLJ6MHJ SYMC_HUMAN Increases Expression [20]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) OTOWDUNT PTEN_HUMAN Affects Expression [20]
Ras-related protein Rab-8A (RAB8A) OTPB54Y3 RAB8A_HUMAN Decreases Expression [20]
Lysozyme C (LYZ) OTD7H0G6 LYSC_HUMAN Decreases Expression [20]
Transforming growth factor beta-2 proprotein (TGFB2) OTC0TXEP TGFB2_HUMAN Increases Expression [20]
Large ribosomal subunit protein eL37 (RPL37) OTB6SDZ1 RL37_HUMAN Increases Expression [20]
Histone H4 (H4C1) OTB71W46 H4_HUMAN Decreases Expression [20]
C-C motif chemokine 20 (CCL20) OTUCJY4N CCL20_HUMAN Increases Expression [20]
ADP-ribosylation factor 1 (ARF1) OT5C4C3L ARF1_HUMAN Decreases Expression [20]
Nuclear factor NF-kappa-B p100 subunit (NFKB2) OTS231V7 NFKB2_HUMAN Affects Expression [20]
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase , mitochondrial (ALDH6A1) OT8LCZCT MMSA_HUMAN Increases Expression [20]
Pro-neuregulin-1, membrane-bound isoform (NRG1) OTZO6F1X NRG1_HUMAN Increases Expression [20]
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) OTFH9M73 PTN11_HUMAN Affects Expression [20]
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1) OTG2T749 CP24A_HUMAN Decreases Expression [20]
ATP-dependent RNA helicase A (DHX9) OT5AAOQI DHX9_HUMAN Decreases Expression [20]
Nuclear cap-binding protein subunit 1 (NCBP1) OTYBR927 NCBP1_HUMAN Increases Expression [20]
TP53-binding protein 1 (TP53BP1) OTL8879S TP53B_HUMAN Increases Expression [20]
Ankyrin-3 (ANK3) OTJ3IRBP ANK3_HUMAN Increases Expression [20]
TNF receptor-associated factor 1 (TRAF1) OTTLM5RU TRAF1_HUMAN Affects Expression [20]
PDZK1-interacting protein 1 (PDZK1IP1) OTWA6M5K PDZ1I_HUMAN Increases Expression [20]
Treacle protein (TCOF1) OT4BOYTM TCOF_HUMAN Decreases Expression [20]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Affects Expression [20]
Baculoviral IAP repeat-containing protein 2 (BIRC2) OTFXFREP BIRC2_HUMAN Increases Expression [20]
Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) OTD1KRKO DYHC1_HUMAN Decreases Expression [20]
Enhancer of filamentation 1 (NEDD9) OTGCFN4M CASL_HUMAN Increases Expression [20]
Interferon regulatory factor 3 (IRF3) OT81U8ME IRF3_HUMAN Decreases Expression [20]
FXYD domain-containing ion transport regulator 3 (FXYD3) OT9PPRHE FXYD3_HUMAN Increases Expression [20]
Ankyrin repeat domain-containing protein 1 (ANKRD1) OTHJ7JV9 ANKR1_HUMAN Increases Expression [20]
Disks large homolog 2 (DLG2) OTQ3BD8U DLG2_HUMAN Increases Expression [20]
Cysteine and glycine-rich protein 2 (CSRP2) OT4SW0HI CSRP2_HUMAN Increases Expression [20]
Cyclin-G2 (CCNG2) OTII38K2 CCNG2_HUMAN Increases Expression [20]
Golgi-associated kinase 1B (GASK1B) OT2HPHEI GAK1B_HUMAN Decreases Expression [20]
SUZ domain-containing protein 1 (SZRD1) OTJMEJWT SZRD1_HUMAN Decreases Expression [20]
Leucine-rich repeat-containing protein 28 (LRRC28) OTFTT6VN LRC28_HUMAN Increases Expression [20]
Mitochondrial basic amino acids transporter (SLC25A29) OT09PIFE S2529_HUMAN Increases Expression [20]
Equilibrative nucleobase transporter 1 (SLC43A3) OTR60ZLA S43A3_HUMAN Decreases Expression [20]
Proprotein convertase subtilisin/kexin type 9 (PCSK9) OTI0DU9Y PCSK9_HUMAN Increases Expression [20]
E3 ubiquitin-protein ligase RNF149 (RNF149) OT6SBKQV RN149_HUMAN Increases Expression [20]
F-box only protein 25 (FBXO25) OTDFA7F4 FBX25_HUMAN Increases Expression [20]
Solute carrier family 2, facilitated glucose transporter member 14 (SLC2A14) OTBFIOVY GTR14_HUMAN Increases Expression [20]
Membrane progestin receptor beta (PAQR8) OTGZ8W9F PAQR8_HUMAN Increases Expression [20]
Nuclear receptor subfamily 4 group A member 3 (NR4A3) OTPBE9R1 NR4A3_HUMAN Increases Expression [20]
La-related protein 4B (LARP4B) OT2HI0QE LAR4B_HUMAN Increases Expression [20]
Collagen triple helix repeat-containing protein 1 (CTHRC1) OTV88X2G CTHR1_HUMAN Increases Expression [20]
BTB/POZ domain-containing protein KCTD12 (KCTD12) OTPYKT4Z KCD12_HUMAN Decreases Expression [20]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (MAGI1) OTMV4ASV MAGI1_HUMAN Increases Expression [20]
Sialidase-1 (NEU1) OTH9BY8Y NEUR1_HUMAN Increases Expression [20]
Galactosylceramide sulfotransferase (GAL3ST1) OTSFFZRD G3ST1_HUMAN Decreases Expression [20]
Junctional adhesion molecule C (JAM3) OTX0F9QL JAM3_HUMAN Decreases Expression [20]
SLIT and NTRK-like protein 2 (SLITRK2) OTPVI22J SLIK2_HUMAN Increases Expression [20]
Anaphase-promoting complex subunit 1 (ANAPC1) OT2YY35L APC1_HUMAN Increases Expression [20]
Anthrax toxin receptor 1 (ANTXR1) OT5W1GPC ANTR1_HUMAN Affects Expression [20]
Ras-related GTP-binding protein D (RRAGD) OTXLVWAH RRAGD_HUMAN Increases Expression [20]
DNA damage-inducible transcript 4 protein (DDIT4) OTHY8SY4 DDIT4_HUMAN Affects Expression [20]
Intersectin-2 (ITSN2) OT8S0OO8 ITSN2_HUMAN Increases Expression [20]
Probable ribosome biogenesis protein RLP24 (RSL24D1) OT6KI56F RLP24_HUMAN Increases Expression [20]
Transcription elongation factor A protein-like 9 (TCEAL9) OT4UHDB5 TCAL9_HUMAN Increases Expression [20]
Histone deacetylase 9 (HDAC9) OTO8O0LF HDAC9_HUMAN Increases Expression [20]
Phosphoserine aminotransferase (PSAT1) OTVV1YV9 SERC_HUMAN Increases Expression [20]
Chloride intracellular channel protein 4 (CLIC4) OT6KTPKD CLIC4_HUMAN Increases Expression [20]
Alpha-2-macroglobulin (A2M) OTFTX90K A2MG_HUMAN Increases Expression [170]
Pro-epidermal growth factor (EGF) OTANRJ0L EGF_HUMAN Decreases Expression [170]
Insulin (INS) OTZ85PDU INS_HUMAN Increases Expression [170]
Lymphotoxin-alpha (LTA) OTUC3S76 TNFB_HUMAN Increases Expression [170]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Increases Expression [170]
Interferon gamma (IFNG) OTXG9JM7 IFNG_HUMAN Decreases Expression [170]
Interleukin-1 alpha (IL1A) OTPSGILV IL1A_HUMAN Decreases Expression [170]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Decreases Expression [170]
Serum amyloid P-component (APCS) OT76JZ8Z SAMP_HUMAN Decreases Expression [170]
Beta-2-glycoprotein 1 (APOH) OTFMUX6O APOH_HUMAN Increases Expression [170]
Alpha-fetoprotein (AFP) OT9GG3ZI FETA_HUMAN Decreases Expression [170]
Granulocyte-macrophage colony-stimulating factor (CSF2) OT1M7D28 CSF2_HUMAN Decreases Expression [170]
Interleukin-4 (IL4) OTOXBWAU IL4_HUMAN Decreases Expression [170]
Myeloperoxidase (MPO) OTOOXLIN PERM_HUMAN Increases Expression [170]
Endothelin-1 (EDN1) OTZCACEG EDN1_HUMAN Decreases Expression [170]
Intercellular adhesion molecule 1 (ICAM1) OTTOIX77 ICAM1_HUMAN Decreases Expression [170]
Stromelysin-1 (MMP3) OTGBI74Z MMP3_HUMAN Decreases Expression [170]
Coagulation factor VII (F7) OTGNJ97M FA7_HUMAN Decreases Expression [170]
Fibroblast growth factor 2 (FGF2) OT7YUJ9F FGF2_HUMAN Increases Expression [170]
Granulocyte colony-stimulating factor (CSF3) OT9GC6TP CSF3_HUMAN Decreases Expression [170]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Decreases Expression [170]
C-C motif chemokine 3 (CCL3) OTW2H3ND CCL3_HUMAN Increases Expression [170]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Decreases Expression [170]
Prostatic acid phosphatase (ACP3) OTSIM0YG PPAP_HUMAN Decreases Expression [170]
Kit ligand (KITLG) OTB9AVQ4 SCF_HUMAN Decreases Expression [170]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Decreases Expression [170]
Brain-derived neurotrophic factor (BDNF) OTLGH7EW BDNF_HUMAN Decreases Expression [170]
CD40 ligand (CD40LG) OT75Z6A6 CD40L_HUMAN Decreases Expression [170]
Interleukin-13 (IL13) OTI4YS3Y IL13_HUMAN Increases Expression [170]
Thrombopoietin (THPO) OTO73DZ2 TPO_HUMAN Increases Expression [170]
Interleukin-15 (IL15) OTQSYWQS IL15_HUMAN Decreases Expression [170]
Leptin (LEP) OT5Q7ODW LEP_HUMAN Decreases Expression [170]
Pappalysin-1 (PAPPA) OTTTG9PG PAPP1_HUMAN Decreases Expression [170]
Pro-interleukin-16 (IL16) OTZ2MO6B IL16_HUMAN Increases Expression [170]
Adiponectin (ADIPOQ) OTNX23LE ADIPO_HUMAN Increases Expression [170]
Aldehyde dehydrogenase 1A1 (ALDH1A1) OTCUWZKB AL1A1_HUMAN Decreases Expression [187]
Neurogenic locus notch homolog protein 1 (NOTCH1) OTI1WADQ NOTC1_HUMAN Increases Expression [187]
Proto-oncogene c-Rel (REL) OTTCKMAC REL_HUMAN Decreases Expression [187]
Telomerase reverse transcriptase (TERT) OT085VVA TERT_HUMAN Decreases Activity [188]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [189]
Nuclear protein 1 (NUPR1) OT4FU8C0 NUPR1_HUMAN Decreases Expression [190]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Decreases Expression [191]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Expression [192]
Insulin-like growth factor 1 receptor (IGF1R) OTXJIF13 IGF1R_HUMAN Decreases Expression [185]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [193]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [194]
Zinc finger protein GLI2 (GLI2) OTIRV97L GLI2_HUMAN Affects Expression [185]
Clusterin (CLU) OTQGG0JM CLUS_HUMAN Increases Expression [195]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Decreases Expression [185]
Serine/threonine-protein kinase B-raf (BRAF) OT7S81XQ BRAF_HUMAN Decreases Expression [185]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Increases Expression [193]
CD44 antigen (CD44) OT9TTJ41 CD44_HUMAN Affects Expression [183]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Expression [196]
Insulin-like growth factor-binding protein 3 (IGFBP3) OTIX63TX IBP3_HUMAN Affects Expression [185]
Cannabinoid receptor 1 (CNR1) OTEALO6G CNR1_HUMAN Increases Expression [197]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Increases Expression [198]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Increases Phosphorylation [186]
Aryl hydrocarbon receptor nuclear translocator (ARNT) OTMSIEZY ARNT_HUMAN Increases Expression [185]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Increases Phosphorylation [186]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Increases Methylation [199]
Cannabinoid receptor 2 (CNR2) OTYP9P43 CNR2_HUMAN Increases Expression [197]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Increases Expression [200]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Increases Expression [185]
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Decreases Activity [201]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [202]
Proliferation marker protein Ki-67 (MKI67) OTA8N1QI KI67_HUMAN Decreases Expression [189]
Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) OTI2OREX MP2K3_HUMAN Increases Phosphorylation [203]
Transcription factor SOX-2 (SOX2) OTFAWCAU SOX2_HUMAN Increases Expression [200]
Glycogen synthase kinase-3 beta (GSK3B) OTL3L14B GSK3B_HUMAN Increases Phosphorylation [204]
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6) OTK13JKC MP2K6_HUMAN Increases Phosphorylation [203]
Serine/threonine-protein kinase PLK1 (PLK1) OTRZX45T PLK1_HUMAN Decreases Expression [185]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Activity [202]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Increases Cleavage [205]
C-X-C chemokine receptor type 4 (CXCR4) OTUFSBX2 CXCR4_HUMAN Affects Expression [185]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Decreases Expression [185]
POU domain, class 5, transcription factor 1 (POU5F1) OTDHHN7O PO5F1_HUMAN Decreases Expression [183]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Increases Expression [206]
Regenerating islet-derived protein 3-alpha (REG3A) OT0BVQRB REG3A_HUMAN Decreases Expression [204]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [186]
Protein patched homolog 1 (PTCH1) OTMG07H5 PTC1_HUMAN Affects Expression [185]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Activity [202]
Sonic hedgehog protein (SHH) OTOG2BXF SHH_HUMAN Decreases Expression [185]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Increases Expression [193]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1) OT2363Z9 T53I1_HUMAN Increases Expression [204]
Protein smoothened (SMO) OTXXE208 SMO_HUMAN Increases Expression [200]
Homeobox protein NANOG (NANOG) OTUEY1FM NANOG_HUMAN Decreases Expression [200]
Axin-2 (AXIN2) OTRMGQNU AXIN2_HUMAN Affects Expression [185]
3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D) OT1RWFV0 PDE4D_HUMAN Increases ADR [143]
Focal adhesion kinase 1 (PTK2) OT3Q1JDY FAK1_HUMAN Decreases Response To Substance [207]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Affects Response To Substance [208]
Splicing factor 45 (RBM17) OT9ROJCL SPF45_HUMAN Decreases Response To Substance [209]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Affects Response To Substance [210]
Neuropilin-1 (NRP1) OTCGULYV NRP1_HUMAN Decreases Response To Substance [138]
Oxysterol-binding protein 2 (OSBP2) OTDGLB4J OSBP2_HUMAN Increases ADR [143]
Proto-oncogene tyrosine-protein kinase Src (SRC) OTETYX40 SRC_HUMAN Decreases Response To Substance [211]
Equilibrative nucleoside transporter 3 (SLC29A3) OTGLX8XU S29A3_HUMAN Affects Transport [212]
Probable ATP-dependent RNA helicase DDX53 (DDX53) OTHK3EGZ DDX53_HUMAN Affects Response To Substance [213]
Amphiregulin (AREG) OTJFOR67 AREG_HUMAN Decreases Response To Substance [214]
Pyruvate kinase PKM (PKM) OTLHHMC2 KPYM_HUMAN Affects Response To Substance [189]
Equilibrative nucleoside transporter 1 (SLC29A1) OTLOOZZS S29A1_HUMAN Increases Response To Substance [215]
Alpha-protein kinase 3 (ALPK3) OTLUYSMO ALPK3_HUMAN Increases ADR [143]
Transcription factor AP-2-alpha (TFAP2A) OTMYT3NK AP2A_HUMAN Increases Response To Substance [216]
Death-associated protein kinase 1 (DAPK1) OTNCNUCO DAPK1_HUMAN Increases ADR [217]
Cytochrome c oxidase subunit 3 (COX3) OTNNGBYJ COX3_HUMAN Decreases Response To Substance [218]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Decreases Response To Substance [219]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Increases ADR [122]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Affects Response To Substance [220]
3-phosphoinositide-dependent protein kinase 1 (PDPK1) OTT09ZVP PDPK1_HUMAN Decreases Response To Substance [221]
Nucleophosmin (NPM1) OTTBYYT0 NPM_HUMAN Decreases Response To Substance [163]
Serine/threonine-protein kinase SMG1 (SMG1) OTTS3SXE SMG1_HUMAN Decreases Response To Substance [222]
ATP-dependent DNA helicase PIF1 (PIF1) OTUHKKVP PIF1_HUMAN Decreases Response To Substance [196]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Decreases Response To Substance [223]
Ribonucleoside-diphosphate reductase large subunit (RRM1) OTXGQOR9 RIR1_HUMAN Increases ADR [224]
Olfactory receptor 4D6 (OR4D6) OTXJKUT1 OR4D6_HUMAN Affects Response To Substance [213]
PDZ domain-containing protein GIPC1 (GIPC1) OTXLVCPJ GIPC1_HUMAN Affects Response To Substance [225]
Integrin-linked protein kinase (ILK) OTYG2FD1 ILK_HUMAN Affects Response To Substance [208]
Poly polymerase 2 (PARP2) OTYL81ZI PARP2_HUMAN Decreases Response To Substance [226]
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⏷ Show the Full List of 244 DOT(s)

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Breast and ovarian cancer syndrome DCU1EKM UWB1289+BRCA1 Investigative [227]
Colon carcinoma DCM7JP9 RKO Investigative [227]
Invasive ductal carcinoma DCAHIF1 T-47D Investigative [227]
Adenocarcinoma DCDI7RL CAOV3 Investigative [1]
Adenocarcinoma DCZV1CV A427 Investigative [1]
Adenocarcinoma DC8XZDL NCIH23 Investigative [1]
Adenocarcinoma DCI7OR3 NCIH520 Investigative [1]
Germ cell tumour DCA53PF PA1 Investigative [1]
Large cell lung carcinoma DC942A5 NCI-H460 Investigative [1]
Malignant melanoma DC34U36 RPMI7951 Investigative [1]
Malignant melanoma DCSVNOF SKMEL30 Investigative [1]
Ovarian serous cystadenocarcinoma DCENY78 SK-OV-3 Investigative [1]
------------------------------------------------------------------------------------
⏷ Show the Full List of 12 DrugCom(s)

References

1 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
2 Fluorouracil FDA Label
3 Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
4 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
5 Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207.
6 Gemcitabine FDA Label
7 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
8 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4793).
9 Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection. Antimicrob Agents Chemother. 2014 Aug;58(8):4885-93.
10 Influence of chemotherapeutic agents and cytokines on the expression of 5-fluorouracil-associated enzymes in human colon cancer cell lines. J Gastroenterol. 2006 Feb;41(2):140-50.
11 Comparison of gene expression in HCT116 treatment derivatives generated by two different 5-fluorouracil exposure protocols. Mol Cancer. 2004 Apr 26;3:11.
12 Thymidylate synthase pharmacogenetics. Invest New Drugs. 2005 Dec;23(6):533-7. doi: 10.1007/s10637-005-4021-7.
13 Orotate phosphoribosyltransferase expression level in tumors is a potential determinant of the efficacy of 5-fluorouracil. Biochem Biophys Res Commun. 2007 Nov 9;363(1):216-22. doi: 10.1016/j.bbrc.2007.08.164. Epub 2007 Sep 6.
14 Cell-type-specific responses to chemotherapeutics in breast cancer. Cancer Res. 2004 Jun 15;64(12):4218-26.
15 Identification of novel genes associated with the response to 5-FU treatment in gastric cancer cell lines using a cDNA microarray. Cancer Lett. 2004 Oct 8;214(1):19-33.
16 Proteomic analysis of antiproliferative effects by treatment of 5-fluorouracil in cervical cancer cells. DNA Cell Biol. 2004 Nov;23(11):769-76.
17 Pharmacogenomic identification of novel determinants of response to chemotherapy in colon cancer. Cancer Res. 2006 Mar 1;66(5):2765-77.
18 Transcriptional profiling of MCF7 breast cancer cells in response to 5-Fluorouracil: relationship with cell cycle changes and apoptosis, and identification of novel targets of p53. Int J Cancer. 2006 Sep 1;119(5):1164-75.
19 Analysis of the in vitro synergistic effect of 5-fluorouracil and cisplatin on cervical carcinoma cells. Int J Gynecol Cancer. 2006 May-Jun;16(3):1321-9.
20 Gene expression profiling of breast cancer cells in response to gemcitabine: NF-kappaB pathway activation as a potential mechanism of resistance. Breast Cancer Res Treat. 2007 Apr;102(2):157-72.
21 Apoptosis, cell cycle progression and gene expression in TP53-depleted HCT116 colon cancer cells in response to short-term 5-fluorouracil treatment. Int J Oncol. 2007 Dec;31(6):1491-500.
22 Expression profiling of nucleotide metabolism-related genes in human breast cancer cells after treatment with 5-fluorouracil. Cancer Invest. 2009 Jun;27(5):561-7.
23 Evaluation of developmental toxicity using undifferentiated human embryonic stem cells. J Appl Toxicol. 2015 Feb;35(2):205-18.
24 New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids. Arch Toxicol. 2021 Aug;95(8):2691-2718. doi: 10.1007/s00204-021-03092-2. Epub 2021 Jun 20.
25 Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancer. BMC Genomics. 2006 Apr 3;7:68. doi: 10.1186/1471-2164-7-68.
26 Dissecting progressive stages of 5-fluorouracil resistance in vitro using RNA expression profiling. Int J Cancer. 2004 Nov 1;112(2):200-12. doi: 10.1002/ijc.20401.
27 Resveratrol induces chemosensitization to 5-fluorouracil through up-regulation of intercellular junctions, Epithelial-to-mesenchymal transition and apoptosis in colorectal cancer. Biochem Pharmacol. 2015 Nov 1;98(1):51-68. doi: 10.1016/j.bcp.2015.08.105. Epub 2015 Aug 24.
28 Fluorodeoxyuridine modulates cellular expression of the DNA base excision repair enzyme uracil-DNA glycosylase. Cancer Res. 2006 Sep 1;66(17):8829-37. doi: 10.1158/0008-5472.CAN-06-0540.
29 Exposure-based assessment of chemical teratogenicity using morphogenetic aggregates of human embryonic stem cells. Reprod Toxicol. 2020 Jan;91:74-91. doi: 10.1016/j.reprotox.2019.10.004. Epub 2019 Nov 8.
30 Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery. Mol Cancer. 2006 May 18;5:20. doi: 10.1186/1476-4598-5-20.
31 Novel proapoptotic agent SM-1 enhances the inhibitory effect of 5-fluorouracil on colorectal cancer cells in vitro and in vivo. Oncol Lett. 2017 Jun;13(6):4762-4768. doi: 10.3892/ol.2017.6043. Epub 2017 Apr 19.
32 Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
33 Identification of XAF1-MT2A mutual antagonism as a molecular switch in cell-fate decisions under stressful conditions. Proc Natl Acad Sci U S A. 2017 May 30;114(22):5683-5688. doi: 10.1073/pnas.1700861114. Epub 2017 May 15.
34 5-Fluorouracil up-regulates interferon pathway gene expression in esophageal cancer cells. Anticancer Res. 2005 Sep-Oct;25(5):3271-8.
35 Rare sugar D-allose enhances anti-tumor effect of 5-fluorouracil on the human hepatocellular carcinoma cell line HuH-7. J Biosci Bioeng. 2008 Sep;106(3):248-52. doi: 10.1263/jbb.106.248.
36 The previously undescribed ZKSCAN3 (ZNF306) is a novel "driver" of colorectal cancer progression. Cancer Res. 2008 Jun 1;68(11):4321-30. doi: 10.1158/0008-5472.CAN-08-0407.
37 Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
38 Mechanistic and predictive profiling of 5-Fluorouracil resistance in human cancer cells. Cancer Res. 2004 Nov 15;64(22):8167-76. doi: 10.1158/0008-5472.CAN-04-0970.
39 Arsenic trioxide reverses the chemoresistance in hepatocellular carcinoma: a targeted intervention of 14-3-3/NF-B feedback loop. J Exp Clin Cancer Res. 2018 Dec 20;37(1):321. doi: 10.1186/s13046-018-1005-y.
40 Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer. Sci Transl Med. 2011 Jan 26;3(67):67ra7. doi: 10.1126/scitranslmed.3001922.
41 HCRP1 inhibits cell proliferation and invasion and promotes chemosensitivity in esophageal squamous cell carcinoma. Chem Biol Interact. 2019 Aug 1;308:357-363. doi: 10.1016/j.cbi.2019.05.032. Epub 2019 May 29.
42 The efficacy of the combination therapy of 5-fluorouracil, cisplatin and leucovorin for hepatocellular carcinoma and its predictable factors. Cancer Chemother Pharmacol. 2004 Apr;53(4):296-304.
43 Enhancement of the antitumour activity of 5-fluorouracil (5-FU) by inhibiting dihydropyrimidine dehydrogenase activity (DPD) using 5-chloro-2,4-dihydroxypyridine (CDHP) in human tumour cells. Eur J Cancer. 2002 Jun;38(9):1271-7.
44 Enhancing chemosensitivity in oral squamous cell carcinoma by lentivirus vector-mediated RNA interference targeting EGFR and MRP2. Oncol Lett. 2016 Sep;12(3):2107-2114.
45 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
46 Role of BCRP as a biomarker for predicting resistance to 5-fluorouracil in breast cancer. Cancer Chemother Pharmacol. 2009 May;63(6):1103-10.
47 Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]). J Pharm Pharmacol. 2005 May;57(5):573-8.
48 ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. Pancreatology. 2009;9(1-2):136-44.
49 Human equilibrative nucleoside transporter 1, as a predictor of 5-fluorouracil resistance in human pancreatic cancer. Anticancer Res. 2007 Jul-Aug;27(4B):2241-9.
50 Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes. Drug Metab Dispos. 2000 Dec;28(12):1457-63.
51 5-Fluorouracil toxicity-attributable IVS14 + 1G > A mutation of the dihydropyrimidine dehydrogenase gene in Polish colorectal cancer patients. Pharmacol Rep. 2008 Mar-Apr;60(2):238-42.
52 5-Fluorouracil pharmacogenomics: still rocking after all these years? Pharmacogenomics. 2011 Feb;12(2):251-65.
53 PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150653776)
54 Orotate phosphoribosyltransferase is overexpressed in malignant pleural mesothelioma: Dramatically responds one case in high OPRT expression. Rare Dis. 2016 Apr 5;4(1):e1165909.
55 Uridine phosphorylase in breast cancer: a new prognostic factor? Front Biosci. 2006 Sep 1;11:2759-66.
56 Combined suicide gene therapy for human colon cancer cells using adenovirus-mediated transfer of escherichia coli cytosine deaminase gene and Escherichia coli uracil phosphoribosyltransferase gene with 5-fluorocytosine. Cancer Gene Ther. 2000 Jul;7(7):1015-22.
57 Expression of CYP2A6 in tumor cells augments cellular sensitivity to tegafur. Jpn J Cancer Res. 2001 May;92(5):524-8. doi: 10.1111/j.1349-7006.2001.tb01125.x.
58 Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in normal tissue as predictors of fluorouracil sensitivity. J Clin Oncol. 2005 Mar 1;23(7):1365-9. doi: 10.1200/JCO.2005.06.219.
59 Heterozygosity for a point mutation in an invariant splice donor site of dihydropyrimidine dehydrogenase and severe 5-fluorouracil related toxicity. Eur J Cancer. 1997 Nov;33(13):2258-64. doi: 10.1016/s0959-8049(97)00261-x.
60 Schedule-dependent cytotoxicity of 5-fluorouracil and irinotecan in a colon cancer cell line. J Gastroenterol. 2006 Dec;41(12):1149-57.
61 Schedule-dependent therapeutic effects of gemcitabine combined with uracil-tegafur in a human pancreatic cancer xenograft model. Pancreas. 2006 Aug;33(2):142-7. doi: 10.1097/01.mpa.0000226882.48204.26.
62 Mechanism of apoptotic effects induced by 5-fluorouracil on human liver carcinoma Bel7402 cell line. Chin Med J (Engl). 2002 Jul;115(7):968-71.
63 5-Fluorouracil: identification of novel downstream mediators of tumour response. Anticancer Res. 2004 Mar-Apr;24(2A):417-23.
64 Regulation of human peptide transporter 1 (PEPT1) in gastric cancer cells by anticancer drugs. Cancer Lett. 2005 Dec 8;230(1):72-80.
65 Inhibition of Src tyrosine kinase reverts chemoresistance toward 5-fluorouracil in human pancreatic carcinoma cells: an involvement of epidermal growth factor receptor signaling. Oncogene. 2008 Dec 4;27(57):7212-22.
66 5-Fluorouracil-induced RNA stress engages a TRAIL-DISC-dependent apoptosis axis facilitated by p53. Oncotarget. 2015 Dec 22;6(41):43679-97. doi: 10.18632/oncotarget.6030.
67 Regulation of genes of the circadian clock in human colon cancer: reduced period-1 and dihydropyrimidine dehydrogenase transcription correlates in high-grade tumors. Cancer Res. 2007 Aug 15;67(16):7917-22. doi: 10.1158/0008-5472.CAN-07-0133.
68 p53-regulated transcriptional program associated with genotoxic stress-induced apoptosis. J Biol Chem. 2004 May 14;279(20):21183-92. doi: 10.1074/jbc.M311912200. Epub 2004 Mar 11.
69 Partial contribution of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/TRAIL receptor pathway to antitumor effects of interferon-alpha/5-fluorouracil against Hepatocellular Carcinoma. Clin Cancer Res. 2004 Dec 1;10(23):7884-95. doi: 10.1158/1078-0432.CCR-04-0794.
70 Transcriptional repression of IKK by p53 in arsenite-induced GADD45 accumulation and apoptosis. Oncogene. 2019 Jan;38(5):731-746. doi: 10.1038/s41388-018-0478-7. Epub 2018 Sep 3.
71 Combination therapy of interferon-alpha and 5-fluorouracil inhibits tumor angiogenesis in human hepatocellular carcinoma cells by regulating vascular endothelial growth factor and angiopoietins. Oncol Rep. 2007 Oct;18(4):801-9.
72 p53 regulates Toll-like receptor 3 expression and function in human epithelial cell lines. Mol Cell Biol. 2008 Nov;28(21):6557-67. doi: 10.1128/MCB.01202-08. Epub 2008 Sep 8.
73 Role of the Fas/FasL pathway in combination therapy with interferon-alpha and fluorouracil against hepatocellular carcinoma in vitro. J Hepatol. 2007 Jan;46(1):77-88. doi: 10.1016/j.jhep.2006.07.032. Epub 2006 Sep 25.
74 Rebamipide suppresses 5-fluorouracil-induced cell death via the activation of Akt/mTOR pathway and regulates the expression of Bcl-2 family proteins. Toxicol In Vitro. 2018 Feb;46:284-293. doi: 10.1016/j.tiv.2017.10.019. Epub 2017 Oct 17.
75 Characterization of DNA reactive and non-DNA reactive anticancer drugs by gene expression profiling. Mutat Res. 2007 Jun 1;619(1-2):16-29. doi: 10.1016/j.mrfmmm.2006.12.007. Epub 2007 Feb 8.
76 Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol. 2021 Apr;37(2):151-175. doi: 10.1007/s10565-020-09537-1. Epub 2020 Jun 14.
77 [Expression of APRIL in colorectal carcinoma tissues and effects of chemotherapeutic agents on APRIL expression in colorectal carcinoma SW480 cells]. Ai Zheng. 2008 Apr;27(4):369-73.
78 5-Fluorouracil inhibits neural differentiation via Mfn1/2 reduction in human induced pluripotent stem cells. J Toxicol Sci. 2018;43(12):727-734. doi: 10.2131/jts.43.727.
79 Cytotoxic Effects of Cannabinoids on Human HT-29 Colorectal Adenocarcinoma Cells: Different Mechanisms of THC, CBD, and CB83. Int J Mol Sci. 2020 Aug 1;21(15):5533. doi: 10.3390/ijms21155533.
80 Dynamic monitoring of cardio-specific markers and markers of thyroid gland function in cancer patients--a pilot study. Anticancer Res. 2007 Jul-Aug;27(4A):1883-6.
81 Topical fluorouracil for actinic keratoses and photoaging: a clinical and molecular analysis. Arch Dermatol. 2009 Jun;145(6):659-66. doi: 10.1001/archdermatol.2009.97.
82 Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: the roles of caspase-6 and p53. Cancer Biol Ther. 2008 Aug;7(8):1305-12. doi: 10.4161/cbt.7.8.6302. Epub 2008 Aug 16.
83 Thrombogenicity of intravenous 5-fluorouracil alone or in combination with cisplatin. Cancer. 1990 Feb 15;65(4):885-9. doi: 10.1002/1097-0142(19900215)65:4<885::aid-cncr2820650410>3.0.co;2-h.
84 Incorporation of 5-fluorouracil into U2 snRNA blocks pseudouridylation and pre-mRNA splicing in vivo. Nucleic Acids Res. 2007;35(2):550-8. doi: 10.1093/nar/gkl1084. Epub 2006 Dec 14.
85 Fluorouracil induces apoptosis and surface molecule modulation of peripheral blood leukocytes. Clin Lab Haematol. 2004 Oct;26(5):327-33. doi: 10.1111/j.1365-2257.2004.00629.x.
86 Antiproliferative effect of p-Coumaric acid targets UPR activation by downregulating Grp78 in colon cancer. Chem Biol Interact. 2018 Aug 1;291:16-28. doi: 10.1016/j.cbi.2018.06.001. Epub 2018 Jun 5.
87 P38 MAPK, NF-B, and JAK-STAT3 Signaling Pathways Involved in Capecitabine-Induced Hand-Foot Syndrome via Interleukin 6 or Interleukin 8 Abnormal Expression. Chem Res Toxicol. 2022 Mar 21;35(3):422-430. doi: 10.1021/acs.chemrestox.1c00317. Epub 2022 Feb 11.
88 The essential role of p53 in hyperpigmentation of the skin via regulation of paracrine melanogenic cytokine receptor signaling. J Biol Chem. 2009 Feb 13;284(7):4343-53. doi: 10.1074/jbc.M805570200. Epub 2008 Dec 18.
89 p53- and p21-independent apoptosis of squamous cell carcinoma cells induced by 5-fluorouracil and radiation. Oral Oncol. 1998 Nov;34(6):529-37. doi: 10.1016/s1368-8375(98)00036-0.
90 Differential activation of cell death and autophagy results in an increased cytotoxic potential for trifluorothymidine compared to 5-fluorouracil in colon cancer cells. Int J Cancer. 2010 May 15;126(10):2457-68. doi: 10.1002/ijc.24943.
91 The optimal schedule for 5-fluorouracil radiosensitization in colon cancer cell lines. Oncol Rep. 2006 Nov;16(5):1085-91.
92 Molecular basis for the induction of an angiogenesis inhibitor, thrombospondin-1, by 5-fluorouracil. Cancer Res. 2008 Sep 1;68(17):7035-41. doi: 10.1158/0008-5472.CAN-07-6496.
93 Down-regulation of Sonic hedgehog signaling pathway activity is involved in 5-fluorouracil-induced apoptosis and motility inhibition in Hep3B cells. Acta Biochim Biophys Sin (Shanghai). 2008 Sep;40(9):819-29.
94 DNA damaging drugs-induced down-regulation of Bcl-2 is essential for induction of apoptosis in high-risk HPV-positive HEp-2 and KB cells. Cancer Lett. 2006 May 18;236(2):213-21. doi: 10.1016/j.canlet.2005.05.024. Epub 2005 Jul 5.
95 Depletion of O6-methylguanine-DNA methyltransferase by O6-benzylguanine enhances 5-FU cytotoxicity in colon and oral cancer cell lines. Oncol Rep. 2007 Jun;17(6):1461-7.
96 The up-regulation of type I interferon receptor gene plays a key role in hepatocellular carcinoma cells in the synergistic antiproliferative effect by 5-fluorouracil and interferon-alpha. Int J Oncol. 2006 Dec;29(6):1469-78.
97 Establishment of a 13 genes-based molecular prediction score model to discriminate the neurotoxic potential of food relevant-chemicals. Toxicol Lett. 2022 Feb 1;355:1-18. doi: 10.1016/j.toxlet.2021.10.013. Epub 2021 Nov 5.
98 Adjuvant therapy with -tocopherol-induce apoptosis in HT-29 colon cancer via cyclin-dependent cell cycle arrest mechanism. J Biochem Mol Toxicol. 2019 Nov;33(11):e22399. doi: 10.1002/jbt.22399. Epub 2019 Oct 6.
99 5-Fluorouracil induces apoptosis through the suppression of NF-kappaB activity in human salivary gland cancer cells. Biochem Biophys Res Commun. 2000 Jul 14;273(3):1168-74. doi: 10.1006/bbrc.2000.3072.
100 Nicotine increases survival in human colon cancer cells treated with chemotherapeutic drugs. Toxicol In Vitro. 2013 Dec;27(8):2256-63. doi: 10.1016/j.tiv.2013.09.020. Epub 2013 Oct 2.
101 MAP kinase-signaling controls nuclear translocation of tripeptidyl-peptidase II in response to DNA damage and oxidative stress. Biochem Biophys Res Commun. 2010 Aug 27;399(3):324-30. doi: 10.1016/j.bbrc.2010.06.133. Epub 2010 Jul 17.
102 Constitutive expression of interleukin-18 in head and neck squamous carcinoma cells. Head Neck. 2004 Jun;26(6):494-503. doi: 10.1002/hed.20011.
103 Predictive value of GADD153, p21 and c-Jun for chemotherapy response in gastric cancer. Cancer Sci. 2007 May;98(5):707-15. doi: 10.1111/j.1349-7006.2007.00435.x. Epub 2007 Mar 9.
104 Development and applications of a real-time quantitative RT-PCR method (QRT-PCR) for BRCA1 mRNA. Clin Biochem. 2005 Jan;38(1):50-7. doi: 10.1016/j.clinbiochem.2004.09.012.
105 Regulation of p53 stability and function in HCT116 colon cancer cells. J Biol Chem. 2004 Feb 27;279(9):7598-605. doi: 10.1074/jbc.M311732200. Epub 2003 Dec 9.
106 The differential effects of cyclophosphamide, epirubicin and 5-fluorouracil on apoptotic marker (CPP-32), pro-apoptotic protein (p21(WAF-1)) and anti-apoptotic protein (bcl-2) in breast cancer cells. Breast Cancer Res Treat. 2003 Aug;80(3):239-44. doi: 10.1023/A:1024995202135.
107 TNFSF10 (TRAIL), a p53 target gene that mediates p53-dependent cell death. Cancer Biol Ther. 2008 Dec;7(12):2034-8. doi: 10.4161/cbt.7.12.7460.
108 Stunning and its effect on 3H-FDG uptake and key gene expression in breast cancer cells undergoing chemotherapy. J Nucl Med. 2006 Apr;47(4):603-8.
109 Cadmium modifies the cell cycle and apoptotic profiles of human breast cancer cells treated with 5-fluorouracil. Int J Mol Sci. 2013 Aug 12;14(8):16600-16. doi: 10.3390/ijms140816600.
110 Different responses to 5-fluoraouracil in mutagenicity and gene expression between two human lymphoblastoid cell lines with or without TP53 mutation. Acta Med Okayama. 2012;66(2):119-29. doi: 10.18926/AMO/48262.
111 The RNA exosome component hRrp6 is a target for 5-fluorouracil in human cells. Mol Cancer Res. 2008 Jun;6(6):990-5. doi: 10.1158/1541-7786.MCR-07-2217.
112 Evaluation of drug transporters' significance for multidrug resistance in head and neck squamous cell carcinoma. Head Neck. 2011 Jul;33(7):959-68. doi: 10.1002/hed.21559. Epub 2010 Aug 24.
113 Adenoviral-mediated gene transfer of Gadd45a results in suppression by inducing apoptosis and cell cycle arrest in pancreatic cancer cell. J Gene Med. 2009 Jan;11(1):3-13. doi: 10.1002/jgm.1270.
114 Enhanced Bax in oral SCC in relation to antitumor effects of chemotherapy. J Oral Pathol Med. 2005 Feb;34(2):93-9. doi: 10.1111/j.1600-0714.2004.00257.x.
115 gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity. Cancer Res. 2009 Jan 15;69(2):573-82. doi: 10.1158/0008-5472.CAN-08-2088.
116 Effect of resveratrol on proliferation and apoptosis of human pancreatic cancer MIA PaCa-2 cells may?involve inhibition of the Hedgehog signaling pathway. Mol Med Rep. 2014 Nov;10(5):2563-7. doi: 10.3892/mmr.2014.2511. Epub 2014 Aug 21.
117 YB-1 facilitates basal and 5-fluorouracil-inducible expression of the human major vault protein (MVP) gene. Oncogene. 2005 May 19;24(22):3606-18. doi: 10.1038/sj.onc.1208386.
118 An appraisal of cinnamyl sulfonamide hydroxamate derivatives (HDAC?inhibitors) for anti-cancer, anti-angiogenic and anti-metastatic activities in human cancer cells. Chem Biol Interact. 2016 Jun 25;253:112-24. doi: 10.1016/j.cbi.2016.05.008. Epub 2016 May 6.
119 GRAMD4 mimics p53 and mediates the apoptotic function of p73 at mitochondria. Cell Death Differ. 2011 May;18(5):874-86. doi: 10.1038/cdd.2010.153. Epub 2010 Dec 3.
120 Administration of PUMA adenovirus increases the sensitivity of esophageal cancer cells to anticancer drugs. Cancer Biol Ther. 2006 Apr;5(4):380-5. doi: 10.4161/cbt.5.4.2477. Epub 2006 Apr 4.
121 Chemopreventive agents induce programmed death-1-ligand 1 (PD-L1) surface expression in breast cancer cells and promote PD-L1-mediated T cell apoptosis. Mol Immunol. 2008 Mar;45(5):1470-6. doi: 10.1016/j.molimm.2007.08.013. Epub 2007 Oct 24.
122 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
123 Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy. Mol Cancer. 2011 Apr 13;10:37. doi: 10.1186/1476-4598-10-37.
124 Characterization of 5-fluorouracil-resistant cholangiocarcinoma cell lines. Chemotherapy. 2008;54(5):343-51. doi: 10.1159/000151541. Epub 2008 Aug 21.
125 Predicting 5-fluorouracil chemosensitivity of liver metastases from colorectal cancer using primary tumor specimens: three-gene expression model predicts clinical response. Int J Cancer. 2006 Jul 15;119(2):406-13. doi: 10.1002/ijc.21843.
126 Antiapoptotic protein partners fortilin and MCL1 independently protect cells from 5-fluorouracil-induced cytotoxicity. J Biol Chem. 2004 Sep 24;279(39):40868-75. doi: 10.1074/jbc.M401454200. Epub 2004 Jul 15.
127 Down-regulation of CYLD as a trigger for NF-B activation and a mechanism of apoptotic resistance in hepatocellular carcinoma cells. Int J Oncol. 2011 Jan;38(1):121-31.
128 Effect of focal adhesion kinase (FAK) downregulation with FAK antisense oligonucleotides and 5-fluorouracil on the viability of melanoma cell lines. Melanoma Res. 2005 Oct;15(5):357-62. doi: 10.1097/00008390-200510000-00003.
129 [Correlation of sorcin overexpression to multidrug resistance of human gastric cancer cell line SGC7901]. Ai Zheng. 2008 Apr;27(4):337-42.
130 Molecular characterizations of derivatives of HCT116 colorectal cancer cells that are resistant to the chemotherapeutic agent 5-fluorouracil. Int J Oncol. 2004 May;24(5):1279-88.
131 Impairment of APE1 function enhances cellular sensitivity to clinically relevant alkylators and antimetabolites. Mol Cancer Res. 2009 Jun;7(6):897-906. doi: 10.1158/1541-7786.MCR-08-0519. Epub 2009 May 26.
132 CD40 signaling activated by agonistic anti-CD40 monoclonal antibody 5C11 has different effects on biological behavior of gastric carcinoma cells. Immunol Lett. 2010 Jul 8;131(2):120-5. doi: 10.1016/j.imlet.2010.02.007. Epub 2010 Feb 25.
133 Expression of rTSbeta as a 5-fluorouracil resistance marker in patients with primary breast cancer. Oncol Rep. 2008 Apr;19(4):881-8.
134 Reversal of the malignant phenotype of gastric cancer cells by inhibition of RhoA expression and activity. Clin Cancer Res. 2004 Sep 15;10(18 Pt 1):6239-47. doi: 10.1158/1078-0432.CCR-04-0242.
135 Single-cell transcription site activation predicts chemotherapy response in human colorectal tumors. Cancer Res. 2008 Jul 1;68(13):4977-82. doi: 10.1158/0008-5472.CAN-07-6770.
136 Epidermal growth factor receptor vIII enhances tumorigenicity and resistance to 5-fluorouracil in human hepatocellular carcinoma. Cancer Lett. 2009 Jun 28;279(1):30-8. doi: 10.1016/j.canlet.2009.01.019. Epub 2009 Feb 12.
137 Reg IV is a serum biomarker for gastric cancer patients and predicts response to 5-fluorouracil-based chemotherapy. Oncogene. 2007 Jun 28;26(30):4383-93. doi: 10.1038/sj.onc.1210215. Epub 2007 Jan 22.
138 Overexpression of neuropilin-1 promotes constitutive MAPK signalling and chemoresistance in pancreatic cancer cells. Br J Cancer. 2005 Jul 25;93(2):233-41. doi: 10.1038/sj.bjc.6602663.
139 [Knock-down of apollon gene by antisense oligodeoxynucleotide inhibits the proliferation of Lovo cells and enhances chemo-sensitivity]. Yao Xue Xue Bao. 2011 Feb;46(2):138-45.
140 Overexpression and significance of prion protein in gastric cancer and multidrug-resistant gastric carcinoma cell line SGC7901/ADR. Int J Cancer. 2005 Jan 10;113(2):213-20. doi: 10.1002/ijc.20570.
141 A new high resolution screening method for study of phenotype stress responses of Saccharomyces cerevisae mutants. J Microbiol Methods. 2011 Dec;87(3):363-7. doi: 10.1016/j.mimet.2011.10.003. Epub 2011 Oct 8.
142 Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer. Gastroenterology. 2008 Oct;135(4):1358-1368, 1368.e1-4. doi: 10.1053/j.gastro.2008.06.082. Epub 2008 Jul 3.
143 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Cancer Sci. 2013 Aug;104(8):1074-82. doi: 10.1111/cas.12186. Epub 2013 Jun 10.
144 Decreased expression of hMLH1 correlates with reduced 5-fluorouracil-mediated apoptosis in colon cancer cells. Oncol Rep. 2007 Nov;18(5):1129-37.
145 Silencing of keratinocyte growth factor receptor restores 5-fluorouracil and tamoxifen efficacy on responsive cancer cells. PLoS One. 2008 Jun 25;3(6):e2528. doi: 10.1371/journal.pone.0002528.
146 Heat shock protein 27, a novel regulator of 5-fluorouracil resistance in colon cancer. Oncol Rep. 2008 Nov;20(5):1165-72.
147 Detection of potassium currents and regulation of multidrug resistance by potassium channels in human gastric cancer cells. Cell Biol Int. 2007 Jul;31(7):741-7. doi: 10.1016/j.cellbi.2007.01.008. Epub 2007 Jan 21.
148 Tudor staphylococcal nuclease drives chemoresistance of non-small cell lung carcinoma cells by regulating S100A11. Oncotarget. 2015 May 20;6(14):12156-73. doi: 10.18632/oncotarget.3495.
149 Targeted inhibition of Livin resensitizes renal cancer cells towards apoptosis. Cell Mol Life Sci. 2007 May;64(9):1137-44. doi: 10.1007/s00018-007-6510-7.
150 Therapeutic targeting of the endothelin a receptor in human nasopharyngeal carcinoma. Cancer Sci. 2006 Dec;97(12):1388-95. doi: 10.1111/j.1349-7006.2006.00333.x. Epub 2006 Oct 9.
151 Interferon-gamma sensitizes hepatitis B virus-expressing hepatocarcinoma cells to 5-fluorouracil through inhibition of hepatitis B virus-mediated nuclear factor-kappaB activation. Cancer Sci. 2007 Nov;98(11):1758-66. doi: 10.1111/j.1349-7006.2007.00591.x. Epub 2007 Aug 16.
152 Prediction of chemosensitivity using multigene analysis in head and neck squamous cell carcinoma. Oncology. 2007;73(1-2):104-11. doi: 10.1159/000120998. Epub 2008 Mar 13.
153 Alterations in the glycolipid composition and cellular properties of ovarian carcinoma-derived RMG-1 cells on transfection of the alpha1,2-fucosyltransferase gene. Cancer Sci. 2005 Jan;96(1):26-30. doi: 10.1111/j.1349-7006.2005.00005.x.
154 Inactivating mutation of the pro-apoptotic gene BID in gastric cancer. J Pathol. 2004 Apr;202(4):439-45. doi: 10.1002/path.1532.
155 Comparative proteomic analysis of SLC13A5 knockdown reveals elevated ketogenesis and enhanced cellular toxic response to chemotherapeutic agents in HepG2 cells. Toxicol Appl Pharmacol. 2020 Sep 1;402:115117. doi: 10.1016/j.taap.2020.115117. Epub 2020 Jul 4.
156 Genome-wide expression analysis of therapy-resistant tumors reveals SPARC as a novel target for cancer therapy. J Clin Invest. 2005 Jun;115(6):1492-502. doi: 10.1172/JCI23002. Epub 2005 May 12.
157 The epigenetic modifier HDAC2 and the checkpoint kinase ATM determine the responses of microsatellite instable colorectal cancer cells to 5-fluorouracil. Cell Biol Toxicol. 2023 Oct;39(5):2401-2419. doi: 10.1007/s10565-022-09731-3. Epub 2022 May 24.
158 Exogenous expression of hRFI induces multidrug resistance through escape from apoptosis in colorectal cancer cells. Anticancer Res. 2005 Jul-Aug;25(4):2737-41.
159 Regulation of multidrug resistance by ribosomal protein l6 in gastric cancer cells. Cancer Biol Ther. 2005 Feb;4(2):242-7. doi: 10.4161/cbt.4.2.1477. Epub 2005 Feb 20.
160 Antitumour effects on human colorectal carcinomas cells by stable silencing of phospholipase C-gamma 1 with lentivirus-delivered siRNA. Chin Med J (Engl). 2007 May 5;120(9):749-54.
161 Reversal of multidrug resistance of vincristine-resistant gastric adenocarcinoma cells through up-regulation of DARPP-32. Cell Biol Int. 2007 Sep;31(9):1010-5. doi: 10.1016/j.cellbi.2007.03.020. Epub 2007 Mar 21.
162 Rho/Rhotekin-mediated NF-kappaB activation confers resistance to apoptosis. Oncogene. 2004 Nov 18;23(54):8731-42. doi: 10.1038/sj.onc.1208106.
163 Proteomic identification of differentially expressed proteins associated with the multiple drug resistance in methotrexate-resistant human breast cancer cells. Int J Oncol. 2014 Jul;45(1):448-58.
164 ABCC11 expression is regulated by estrogen in MCF7 cells, correlated with estrogen receptor alpha expression in postmenopausal breast tumors and overexpressed in tamoxifen-resistant breast cancer cells. Endocr Relat Cancer. 2008 Mar;15(1):125-38. doi: 10.1677/ERC-07-0189.
165 Effects of folylpolyglutamate synthetase modulation on chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate. Gut. 2004 Dec;53(12):1825-31. doi: 10.1136/gut.2004.042713.
166 Periostin induction in tumor cell line explants and inhibition of in vitro cell growth by anti-periostin antibodies. Carcinogenesis. 2005 May;26(5):908-15. doi: 10.1093/carcin/bgi034. Epub 2005 Feb 24.
167 Interferons upregulate thymidine phosphorylase expression via JAK-STAT-dependent transcriptional activation and mRNA stabilization in human glioblastoma cells. J Neurooncol. 2005 May;72(3):217-23. doi: 10.1007/s11060-004-3012-4.
168 Galectin-3 germline variant at position 191 enhances nuclear accumulation and activation of -catenin in gastric cancer. Clin Exp Metastasis. 2011 Dec;28(8):743-50. doi: 10.1007/s10585-011-9406-8. Epub 2011 Jul 13.
169 Recombinant human erythropoietin alpha targets intratumoral blood vessels, improving chemotherapy in human xenograft models. Cancer Res. 2005 Aug 15;65(16):7186-93. doi: 10.1158/0008-5472.CAN-04-2498.
170 Metronomic gemcitabine suppresses tumour growth, improves perfusion, and reduces hypoxia in human pancreatic ductal adenocarcinoma. Br J Cancer. 2010 Jun 29;103(1):52-60.
171 Gemcitabine induces the VMP1-mediated autophagy pathway to promote apoptotic death in human pancreatic cancer cells. Pancreatology. 2010;10(1):19-26. doi: 10.1159/000264680. Epub 2010 Mar 19.
172 XIAP is related to the chemoresistance and inhibited its expression by RNA interference sensitize pancreatic carcinoma cells to chemotherapeutics. Pancreas. 2006 Apr;32(3):288-96. doi: 10.1097/01.mpa.0000218314.67111.fb.
173 Ex vivo chemosensitivity testing and gene expression profiling predict response towards adjuvant gemcitabine treatment in pancreatic cancer. Br J Cancer. 2008 Sep 2;99(5):760-7. doi: 10.1038/sj.bjc.6604528.
174 14-3-3 regulation of and interaction with YAP1 in acquired gemcitabine resistance via promoting ribonucleotide reductase expression. Oncotarget. 2016 Apr 5;7(14):17726-36. doi: 10.18632/oncotarget.7394.
175 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
176 Increased sensitivity to gemcitabine of P-glycoprotein and multidrug resistance-associated protein-overexpressing human cancer cell lines. Br J Cancer. 2003 Jun 16;88(12):1963-70.
177 Interdependence of gemcitabine treatment, transporter expression, and resistance in human pancreatic carcinoma cells. Neoplasia. 2010 Sep;12(9):740-7.
178 Pancreatic Cancer Chemoresistance to Gemcitabine. Cancers (Basel). 2017 Nov 16;9(11).
179 Equilibrative nucleoside transporter 1 genotype, cytidine deaminase activity and age predict gemcitabine plasma clearance in patients with solid tumours. Br J Clin Pharmacol. 2011 Mar;71(3):437-44.
180 Gemcitabine pharmacogenomics: deoxycytidine kinase and cytidylate kinase gene resequencing and functional genomics. Drug Metab Dispos. 2008 Sep;36(9):1951-9.
181 Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Science. 2017 Sep 15;357(6356):1156-1160.
182 Mycoplasma hyorhinis-encoded cytidine deaminase efficiently inactivates cytosine-based anticancer drugs. FEBS Open Bio. 2015 Aug 3;5:634-9.
183 Deregulation of the CD44-NANOG-MDR1 associated chemoresistance pathways of breast cancer stem cells potentiates the anti-cancer effect of Kaempferol in synergism with Verapamil. Toxicol Appl Pharmacol. 2022 Feb 15;437:115887. doi: 10.1016/j.taap.2022.115887. Epub 2022 Jan 19.
184 Regulation of DR-5 protein and mitochondrial transmembrane potential by gemcitabine, a possible mechanism of gemcitabine-enhanced TRAIL-induced apoptosis. Oncol Rep. 2007 Sep;18(3):523-9.
185 A fine-needle aspirate-based vulnerability assay identifies polo-like kinase 1 as a mediator of gemcitabine resistance in pancreatic cancer. Mol Cancer Ther. 2010 Feb;9(2):311-8. doi: 10.1158/1535-7163.MCT-09-0693. Epub 2010 Jan 26.
186 Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway. Eur J Pharmacol. 2004 Oct 19;502(3):169-83. doi: 10.1016/j.ejphar.2004.09.006.
187 Sulforaphane increases drug-mediated cytotoxicity toward cancer stem-like cells of pancreas and prostate. Mol Ther. 2011 Jan;19(1):188-95.
188 Antagonistic interactions between gemcitabine and 5-fluorouracil in the human pancreatic carcinoma cell line Capan-2. Cancer Biol Ther. 2006 Oct;5(10):1294-303. doi: 10.4161/cbt.5.10.3152. Epub 2006 Oct 4.
189 Targeting PKM2 improves the gemcitabine sensitivity of intrahepatic cholangiocarcinoma cells via inhibiting -catenin signaling pathway. Chem Biol Interact. 2024 Jan 5;387:110816. doi: 10.1016/j.cbi.2023.110816. Epub 2023 Nov 22.
190 p8 is a new target of gemcitabine in pancreatic cancer cells. Clin Cancer Res. 2006 Jan 1;12(1):235-41. doi: 10.1158/1078-0432.CCR-05-1700.
191 The anthelmintic drug niclosamide induces GSK--mediated -catenin degradation to potentiate gemcitabine activity, reduce immune evasion ability and suppress pancreatic cancer progression. Cell Death Dis. 2022 Feb 3;13(2):112. doi: 10.1038/s41419-022-04573-7.
192 High-throughput measurement of the Tp53 response to anticancer drugs and random compounds using a stably integrated Tp53-responsive luciferase reporter. Carcinogenesis. 2002 Jun;23(6):949-57. doi: 10.1093/carcin/23.6.949.
193 CASC9 potentiates gemcitabine resistance in pancreatic cancer by reciprocally activating NRF2 and the NF-B signaling pathway. Cell Biol Toxicol. 2023 Aug;39(4):1549-1560. doi: 10.1007/s10565-022-09746-w. Epub 2022 Aug 1.
194 Role of epidermal growth factor receptor degradation in gemcitabine-mediated cytotoxicity. Oncogene. 2007 May 17;26(23):3431-9. doi: 10.1038/sj.onc.1210129. Epub 2006 Dec 4.
195 Chemosensitization of gemcitabine-resistant human bladder cancer cell line both in vitro and in vivo using antisense oligonucleotide targeting the anti-apoptotic gene, clusterin. BJU Int. 2009 Feb;103(3):384-90. doi: 10.1111/j.1464-410X.2008.08098.x. Epub 2008 Oct 24.
196 Petite Integration Factor 1 knockdown enhances gemcitabine sensitivity in pancreatic cancer cells via increasing DNA damage. J Appl Toxicol. 2023 Oct;43(10):1522-1532. doi: 10.1002/jat.4494. Epub 2023 May 16.
197 Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism. Cell Death Dis. 2011 Apr 28;2(4):e152. doi: 10.1038/cddis.2011.36.
198 Gemcitabine-induced apoptosis in 5637 cell line: an in-vitro model for high-risk superficial bladder cancer. Anticancer Drugs. 2007 Feb;18(2):179-85. doi: 10.1097/CAD.0b013e328010ef47.
199 Reversible epigenetic regulation of 14-3-3 expression in acquired gemcitabine resistance by uhrf1 and DNA methyltransferase 1. Mol Pharmacol. 2014 Nov;86(5):561-9. doi: 10.1124/mol.114.092544. Epub 2014 Sep 4.
200 Suppression of cancer relapse and metastasis by inhibiting cancer stemness. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1839-44. doi: 10.1073/pnas.1424171112. Epub 2015 Jan 20.
201 EGCG enhances the therapeutic potential of gemcitabine and CP690550 by inhibiting STAT3 signaling pathway in human pancreatic cancer. PLoS One. 2012;7(2):e31067. doi: 10.1371/journal.pone.0031067. Epub 2012 Feb 13.
202 Caspase activation is required for gemcitabine activity in multiple myeloma cell lines. Mol Cancer Ther. 2002 Nov;1(13):1221-7.
203 Involvement of p38 mitogen-activated protein kinase in gemcitabine-induced apoptosis in human pancreatic cancer cells. Biochem Biophys Res Commun. 2004 Mar 26;316(1):71-7. doi: 10.1016/j.bbrc.2004.02.017.
204 Effect of gemcitabine on the expression of apoptosis-related genes in human pancreatic cancer cells. World J Gastroenterol. 2006 Mar 14;12(10):1597-602. doi: 10.3748/wjg.v12.i10.1597.
205 Resistance of pancreatic cancer to gemcitabine treatment is dependent on mitochondria-mediated apoptosis. Int J Cancer. 2004 Mar 20;109(2):182-8. doi: 10.1002/ijc.11679.
206 Gemcitabine combined with gum mastic causes potent growth inhibition and apoptosis of pancreatic cancer cells. Acta Pharmacol Sin. 2010 Jun;31(6):741-5. doi: 10.1038/aps.2010.54.
207 RNA interference targeting focal adhesion kinase enhances pancreatic adenocarcinoma gemcitabine chemosensitivity. Biochem Biophys Res Commun. 2003 Nov 21;311(3):786-92. doi: 10.1016/j.bbrc.2003.10.060.
208 RNA interference demonstrates a novel role for integrin-linked kinase as a determinant of pancreatic adenocarcinoma cell gemcitabine chemoresistance. Clin Cancer Res. 2005 May 1;11(9):3433-8. doi: 10.1158/1078-0432.CCR-04-1510.
209 Human splicing factor SPF45 (RBM17) confers broad multidrug resistance to anticancer drugs when overexpressed--a phenotype partially reversed by selective estrogen receptor modulators. Cancer Res. 2005 Aug 1;65(15):6593-600. doi: 10.1158/0008-5472.CAN-03-3675.
210 Effect of antisense hypoxia-inducible factor 1alpha on progression, metastasis, and chemosensitivity of pancreatic cancer. Pancreas. 2006 Apr;32(3):297-305. doi: 10.1097/00006676-200604000-00010.
211 Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells. Clin Cancer Res. 2004 Apr 1;10(7):2307-18.
212 Facilitated mitochondrial import of antiviral and anticancer nucleoside drugs by human equilibrative nucleoside transporter-3. Am J Physiol Gastrointest Liver Physiol. 2009 Apr;296(4):G910-22. doi: 10.1152/ajpgi.90672.2008. Epub 2009 Jan 22.
213 Using Whole-Exome Sequencing to Identify Genetic Markers for Carboplatin and Gemcitabine-Induced Toxicities. Clin Cancer Res. 2016 Jan 15;22(2):366-73. doi: 10.1158/1078-0432.CCR-15-0964. Epub 2015 Sep 16.
214 Amphiregulin regulates the activation of ERK and Akt through epidermal growth factor receptor and HER3 signals involved in the progression of pancreatic cancer. Cancer Sci. 2010 Nov;101(11):2351-60. doi: 10.1111/j.1349-7006.2010.01671.x.
215 Laser microdissection and primary cell cultures improve pharmacogenetic analysis in pancreatic adenocarcinoma. Lab Invest. 2008 Jul;88(7):773-84. doi: 10.1038/labinvest.2008.40. Epub 2008 May 19.
216 Increased expression of transcription factor TFAP2 correlates with chemosensitivity in advanced bladder cancer. BMC Cancer. 2011 Apr 14;11:135. doi: 10.1186/1471-2407-11-135.
217 A genome-wide association study identifies four genetic markers for hematological toxicities in cancer patients receiving gemcitabine therapy. Pharmacogenet Genomics. 2012 Apr;22(4):229-35. doi: 10.1097/FPC.0b013e32834e9eba.
218 An increase of cytochrome C oxidase mediated disruption of gemcitabine incorporation into DNA in a resistant KB clone. Biochem Pharmacol. 2007 Jun 15;73(12):1927-38. doi: 10.1016/j.bcp.2007.03.014. Epub 2007 Mar 20.
219 Novel mechanism of reduced proliferation in ovarian clear cell carcinoma cells: cytoplasmic sequestration of CDK2 by p27. Gynecol Oncol. 2011 Sep;122(3):641-7. doi: 10.1016/j.ygyno.2011.05.003. Epub 2011 Jun 8.
220 Triplex-forming oligonucleotides targeting c-MYC potentiate the anti-tumor activity of gemcitabine in a mouse model of human cancer. Mol Carcinog. 2014 Sep;53(9):744-52. doi: 10.1002/mc.22026. Epub 2013 May 16.
221 Differential roles of phosphoinositide-dependent protein kinase-1 and akt1 expression and phosphorylation in breast cancer cell resistance to Paclitaxel, Doxorubicin, and gemcitabine. Mol Pharmacol. 2006 Sep;70(3):1045-52. doi: 10.1124/mol.106.023333. Epub 2006 Jun 16.
222 [Effect of inhibiting the expression of hSMG-1 on chemosensitivity of human non-small cell lung cancer H1299 cells]. Zhonghua Yi Xue Za Zhi. 2011 Mar 1;91(8):554-9.
223 A novel 3-dimensional culture system uncovers growth stimulatory actions by TGF in pancreatic cancer cells. Cancer Biol Ther. 2011 Aug 1;12(3):198-207. doi: 10.4161/cbt.12.3.15979. Epub 2011 Aug 1.
224 An association between RRM1 haplotype and gemcitabine-induced neutropenia in breast cancer patients. Oncologist. 2007 Jun;12(6):622-30. doi: 10.1634/theoncologist.12-6-622.
225 GAIP interacting protein C-terminus regulates autophagy and exosome biogenesis of pancreatic cancer through metabolic pathways. PLoS One. 2014 Dec 3;9(12):e114409. doi: 10.1371/journal.pone.0114409. eCollection 2014.
226 Synergistic chemosensitivity of triple-negative breast cancer cell lines to poly(ADP-Ribose) polymerase inhibition, gemcitabine, and cisplatin. Cancer Res. 2010 Oct 15;70(20):7970-80. doi: 10.1158/0008-5472.CAN-09-4521. Epub 2010 Aug 26.
227 Biologically active neutrophil chemokine pattern in tonsillitis.Clin Exp Immunol. 2004 Mar;135(3):511-8. doi: 10.1111/j.1365-2249.2003.02390.x.