Details of the Drug Combination

General Information of Drug Combination (ID: DC59XH6)

Drug Combination Name
Fluorouracil Dasatinib
Indication
Disease Entry Status REF
Ovarian serous cystadenocarcinoma Investigative [1]
Component Drugs Fluorouracil   DMUM7HZ Dasatinib   DMJV2EK
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: SK-OV-3
Zero Interaction Potency (ZIP) Score: 1.65
Bliss Independence Score: 1.64
Loewe Additivity Score: 0.67
LHighest Single Agent (HSA) Score: 2.12

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Fluorouracil
Disease Entry ICD 11 Status REF
Adenocarcinoma 2D40 Approved [2]
Biliary tract cancer 2C17 Approved [2]
Colon adenocarcinoma N.A. Approved [2]
Esophageal squamous cell carcinoma 2E60.1 Approved [2]
Gastric intestinal type adenocarcinoma N.A. Approved [2]
Gastroesophageal junction adenocarcinoma 2B71 Approved [2]
Metastasis from malignant tumor of colon N.A. Approved [2]
Pancreatic adenocarcinoma N.A. Approved [2]
Rectal adenocarcinoma 2B92 Approved [2]
Rectum mucinous adenocarcinoma N.A. Approved [2]
Solid tumour/cancer 2A00-2F9Z Approved [3]
Colon cancer 2B90.Z Investigative [2]
Colon mucinous adenocarcinoma N.A. Investigative [2]
Colorectal cancer 2B91.Z Investigative [4]
Gastric cancer 2B72 Investigative [2]
Tumour 2A00-2F9Z Investigative [5]
Fluorouracil Interacts with 4 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
TERT messenger RNA (TERT mRNA) TTQY2EJ TERT_HUMAN . [5]
Candida Thymidylate synthase (Candi TMP1) TTU6BFZ TYSY_CANAL Inhibitor [42]
Dihydrothymine dehydrogenase (DPYD) TTZPS91 DPYD_HUMAN Inhibitor [43]
Thymidylate synthase messenger RNA (TYMS mRNA) TTP1UKZ TYSY_HUMAN . [5]
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Fluorouracil Interacts with 8 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [44]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [45]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [46]
Organic anion transporter 2 (SLC22A7) DT0OC1Q S22A7_HUMAN Substrate [47]
Multidrug resistance-associated protein 3 (ABCC3) DTQ3ZHF MRP3_HUMAN Substrate [48]
Multidrug resistance-associated protein 4 (ABCC4) DTCSGPB MRP4_HUMAN Substrate [48]
Multidrug resistance-associated protein 5 (ABCC5) DTYVM24 MRP5_HUMAN Substrate [48]
Equilibrative nucleoside transporter 1 (SLC29A1) DTXD1TQ S29A1_HUMAN Substrate [49]
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⏷ Show the Full List of 8 DTP(s)
Fluorouracil Interacts with 12 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [50]
Cytochrome P450 2A6 (CYP2A6) DEJVYAZ CP2A6_HUMAN Metabolism [50]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [50]
Dihydrothymine dehydrogenase (DPYD) DESOEW1 DPYD_HUMAN Metabolism [51]
Methylenetetrahydrofolate reductase (MTHFR) DEOXTPZ MTHR_HUMAN Metabolism [52]
Thymidine phosphorylase (TYMP) DE4HCYL TYPH_HUMAN Metabolism [52]
Amidophosphoribosyltransferase (GPAT) DEMJ7R2 PUR1_HUMAN Metabolism [53]
Thymidylate synthase (TYMS) DEASG0Q TYSY_HUMAN Metabolism [52]
Uridine 5'-monophosphate synthase (UMPS) DEWJYTE UMPS_HUMAN Metabolism [54]
Uridine phosphorylase 1 (UPP1) DEFZWAX UPP1_HUMAN Metabolism [55]
Uridine phosphorylase 2 (UPP2) DEBQ2WU UPP2_HUMAN Metabolism [55]
Uracil phosphoribosyltransferase (UPRT) DE20ETR UPP_HUMAN Metabolism [56]
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⏷ Show the Full List of 12 DME(s)
Fluorouracil Interacts with 1026 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 2A6 (CYP2A6) OT52TWG3 CP2A6_HUMAN Increases Chemical Synthesis [57]
Methylenetetrahydrofolate reductase (MTHFR) OTUBJSR7 MTHR_HUMAN Increases Response To Substance [58]
Dihydropyrimidine dehydrogenase (DPYD) OTWRF2NR DPYD_HUMAN Increases Response To Substance [59]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Decreases Expression [60]
Equilibrative nucleoside transporter 1 (SLC29A1) OTLOOZZS S29A1_HUMAN Increases Expression [61]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Affects Response To Substance [37]
ATP-binding cassette sub-family C member 5 (ABCC5) OT34G4US MRP5_HUMAN Decreases Response To Substance [48]
Solute carrier family 22 member 7 (SLC22A7) OTKTNH1W S22A7_HUMAN Increases Transport [47]
Glutathione S-transferase P (GSTP1) OTLP0A0Y GSTP1_HUMAN Increases Expression [14]
Nitric oxide synthase, inducible (NOS2) OTKKIOJ1 NOS2_HUMAN Increases Expression [62]
Fanconi anemia group G protein (FANCG) OT7MC8TZ FANCG_HUMAN Increases Expression [11]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L) OTJKOMXE BNI3L_HUMAN Decreases Expression [11]
Dihydrofolate reductase (DHFR) OT3DVIGM DYR_HUMAN Increases Expression [11]
Annexin A4 (ANXA4) OTUCRYXL ANXA4_HUMAN Decreases Expression [11]
Thymidylate kinase (DTYMK) OTJXYQYK KTHY_HUMAN Increases Expression [11]
Flap endonuclease 1 (FEN1) OT6QGG7O FEN1_HUMAN Increases Expression [11]
Interleukin-1 receptor-associated kinase 1 (IRAK1) OT133G8J IRAK1_HUMAN Increases Expression [11]
UV excision repair protein RAD23 homolog B (RAD23B) OT0PGOG3 RD23B_HUMAN Increases Expression [11]
Programmed cell death protein 4 (PDCD4) OTZ6NXUX PDCD4_HUMAN Decreases Expression [11]
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) OTM3H5OA MALT1_HUMAN Increases Expression [11]
RAF proto-oncogene serine/threonine-protein kinase (RAF1) OT51LSFO RAF1_HUMAN Increases Expression [63]
Diamine acetyltransferase 1 (SAT1) OT52AU22 SAT1_HUMAN Increases Expression [63]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Increases Expression [63]
Enoyl-CoA hydratase, mitochondrial (ECHS1) OTS0593S ECHM_HUMAN Increases Expression [63]
Spermine synthase (SMS) OT8JYKNH SPSY_HUMAN Increases Expression [63]
10 kDa heat shock protein, mitochondrial (HSPE1) OT7JSZLB CH10_HUMAN Increases Expression [63]
Thymosin beta-4 (TMSB4X) OT9HPLP3 TYB4_HUMAN Increases Expression [63]
Large ribosomal subunit protein uL14 (RPL23) OTXI1YLM RL23_HUMAN Increases Expression [63]
Small ribosomal subunit protein eS28 (RPS28) OT12IES1 RS28_HUMAN Increases Expression [63]
Thymosin beta-10 (TMSB10) OTLVZ13T TYB10_HUMAN Increases Expression [63]
FXYD domain-containing ion transport regulator 3 (FXYD3) OT9PPRHE FXYD3_HUMAN Increases Expression [63]
Cocaine esterase (CES2) OTC647SQ EST2_HUMAN Increases Expression [14]
Aurora kinase A (AURKA) OTMX0HYT AURKA_HUMAN Decreases Expression [14]
Regulator of G-protein signaling 16 (RGS16) OTBKZASI RGS16_HUMAN Affects Expression [14]
Securin (PTTG1) OTIMYS4W PTTG1_HUMAN Decreases Expression [14]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Decreases Expression [14]
Epoxide hydrolase 1 (EPHX1) OTBKWQER HYEP_HUMAN Increases Expression [14]
DNA topoisomerase 2-alpha (TOP2A) OT6LPS08 TOP2A_HUMAN Decreases Expression [14]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Decreases Expression [14]
Elastin (ELN) OTFSO7PG ELN_HUMAN Affects Expression [14]
Integrin beta-4 (ITGB4) OT28UK84 ITB4_HUMAN Decreases Expression [14]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Decreases Expression [14]
NADPH:adrenodoxin oxidoreductase, mitochondrial (FDXR) OTPDCK1F ADRO_HUMAN Increases Expression [14]
Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1) OTGP6GA4 NR4A1_HUMAN Affects Expression [14]
Corticotropin-releasing factor-binding protein (CRHBP) OT9AB48G CRHBP_HUMAN Affects Expression [14]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [14]
CCN family member 2 (CCN2) OTC39NSU CCN2_HUMAN Affects Expression [14]
DNA replication licensing factor MCM4 (MCM4) OT19PNNG MCM4_HUMAN Affects Expression [14]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Decreases Expression [14]
Chitinase-3-like protein 1 (CHI3L1) OT2Z7VJH CH3L1_HUMAN Increases Expression [14]
L-dopachrome tautomerase (DCT) OTYVNTBG TYRP2_HUMAN Affects Expression [14]
Proliferation marker protein Ki-67 (MKI67) OTA8N1QI KI67_HUMAN Decreases Expression [14]
Serine/threonine-protein kinase PLK1 (PLK1) OTRZX45T PLK1_HUMAN Decreases Expression [14]
GTP-binding protein GEM (GEM) OT6SK8ZV GEM_HUMAN Affects Expression [14]
DNA-binding protein inhibitor ID-3 (ID3) OTUULW5Z ID3_HUMAN Increases Expression [14]
Regulator of G-protein signaling 1 (RGS1) OTGXJYMG RGS1_HUMAN Affects Expression [14]
Dihydropyrimidinase-related protein 3 (DPYSL3) OTINJV20 DPYL3_HUMAN Affects Expression [14]
Elongin-A (ELOA) OTOQTF5K ELOA1_HUMAN Affects Expression [14]
Squalene monooxygenase (SQLE) OT0GGRDO ERG1_HUMAN Decreases Expression [14]
Cyclin-dependent kinase 5 activator 1 (CDK5R1) OTJELWK0 CD5R1_HUMAN Affects Expression [14]
Quinone oxidoreductase PIG3 (TP53I3) OTSCM68G QORX_HUMAN Increases Expression [14]
Probable carboxypeptidase X1 (CPXM1) OTRCSQPG CPXM1_HUMAN Affects Expression [14]
Krueppel-like factor 6 (KLF6) OTQY9S7F KLF6_HUMAN Decreases Expression [14]
Epiphycan (EPYC) OTTRI5WO EPYC_HUMAN Affects Expression [14]
Collagen alpha-1(XII) chain (COL12A1) OTHLTV53 COCA1_HUMAN Decreases Expression [14]
Growth/differentiation factor 15 (GDF15) OTWQN50N GDF15_HUMAN Increases Expression [14]
Spondin-1 (SPON1) OTC06MY4 SPON1_HUMAN Affects Expression [14]
Ras-related protein Rab-21 (RAB21) OTH3WGLG RAB21_HUMAN Affects Expression [14]
Homeobox protein Hox-C11 (HOXC11) OT8NMHM6 HXC11_HUMAN Affects Expression [15]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) OTYG179K PR15A_HUMAN Increases Expression [15]
Amino acid transporter heavy chain SLC3A2 (SLC3A2) OTBR33M9 4F2_HUMAN Increases Expression [15]
Ribonucleoside-diphosphate reductase large subunit (RRM1) OTXGQOR9 RIR1_HUMAN Increases Expression [15]
Serine/arginine-rich splicing factor 11 (SRSF11) OTZSV6CZ SRS11_HUMAN Increases Expression [15]
Unconventional myosin-Ie (MYO1E) OTM9YSIZ MYO1E_HUMAN Increases Expression [15]
Cleavage stimulation factor subunit 3 (CSTF3) OT1Y7B5U CSTF3_HUMAN Increases Expression [15]
Centromere protein Q (CENPQ) OT3M6WAI CENPQ_HUMAN Increases Expression [15]
Arginine/serine-rich coiled-coil protein 2 (RSRC2) OTLE0KQM RSRC2_HUMAN Increases Expression [15]
ADP-ribosylation factor GTPase-activating protein 1 (ARFGAP1) OTM3KHIE ARFG1_HUMAN Increases Expression [15]
DNA damage-binding protein 2 (DDB2) OTO8HVVB DDB2_HUMAN Increases Expression [15]
Spermatogenesis-associated protein 25 (SPATA25) OTJMFF0A SPT25_HUMAN Increases Expression [15]
G-protein coupled receptor 35 (GPR35) OTO23NRK GPR35_HUMAN Increases Expression [15]
Regulation of nuclear pre-mRNA domain-containing protein 1B (RPRD1B) OTB41D5K RPR1B_HUMAN Increases Expression [15]
Transcription factor 19 (TCF19) OT7NKLF9 TCF19_HUMAN Increases Expression [15]
Mitogen-activated protein kinase 13 (MAPK13) OT0W9GE7 MK13_HUMAN Increases Expression [16]
Eukaryotic translation initiation factor 3 subunit H (EIF3H) OT61RBF5 EIF3H_HUMAN Increases Expression [16]
Mitotic checkpoint protein BUB3 (BUB3) OTU91HAU BUB3_HUMAN Decreases Expression [16]
Cytohesin-3 (CYTH3) OTBXAT3Z CYH3_HUMAN Decreases Expression [16]
NADH dehydrogenase 1 alpha subcomplex subunit 10, mitochondrial (NDUFA10) OTBURQ3A NDUAA_HUMAN Increases Expression [16]
GTPase KRas (KRAS) OT78QCN8 RASK_HUMAN Decreases Expression [16]
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) OT47AK4C HNRPC_HUMAN Increases Expression [16]
Histone H1.3 (H1-3) OTT7VPRB H13_HUMAN Increases Expression [16]
Cation-dependent mannose-6-phosphate receptor (M6PR) OTFEWOSB MPRD_HUMAN Increases Expression [16]
Long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADL) OTP7Y0UF ACADL_HUMAN Increases Expression [16]
Endoplasmic reticulum resident protein 29 (ERP29) OTNKANMH ERP29_HUMAN Decreases Expression [16]
Glutathione S-transferase theta-1 (GSTT1) OTRFMWBK GSTT1_HUMAN Increases Expression [16]
Large ribosomal subunit protein uL3 (RPL3) OTX6VXLB RL3_HUMAN Decreases Expression [16]
Aminomethyltransferase, mitochondrial (AMT) OTQYEWZQ GCST_HUMAN Increases Expression [16]
Translation initiation factor eIF2B subunit beta (EIF2B2) OTQQMHM1 EI2BB_HUMAN Decreases Expression [16]
Adenosine 5'-monophosphoramidase HINT1 (HINT1) OTQIR8LF HINT1_HUMAN Increases Expression [16]
D-beta-hydroxybutyrate dehydrogenase, mitochondrial (BDH1) OT62RL5P BDH_HUMAN Decreases Expression [16]
Protein phosphatase 3 catalytic subunit alpha (PPP3CA) OT58PUEN PP2BA_HUMAN Increases Expression [16]
Src substrate cortactin (CTTN) OTJRG4ES SRC8_HUMAN Decreases Expression [16]
Prostaglandin reductase 1 (PTGR1) OTMAR351 PTGR1_HUMAN Increases Expression [16]
Eukaryotic translation initiation factor 4H (EIF4H) OTGZI072 IF4H_HUMAN Increases Expression [16]
Telomeric repeat-binding factor 2 (TERF2) OTBSAS0V TERF2_HUMAN Increases Expression [16]
snRNA-activating protein complex subunit 1 (SNAPC1) OTAPN1NI SNPC1_HUMAN Decreases Expression [16]
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (NUCKS1) OTL4VJC5 NUCKS_HUMAN Decreases Expression [16]
Lipid transferase CIDEB (CIDEB) OT873IYM CIDEB_HUMAN Increases Expression [16]
Homeobox protein BarH-like 2 (BARX2) OT0R3QD3 BARX2_HUMAN Increases Expression [16]
Protocadherin alpha-5 (PCDHA5) OTHZT1GR PCDA5_HUMAN Decreases Expression [16]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) OTA675TJ GTR1_HUMAN Decreases Expression [64]
Solute carrier family 15 member 1 (SLC15A1) OT1P16B5 S15A1_HUMAN Decreases Expression [64]
Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMCHD1) OTBV52DR SMHD1_HUMAN Increases Expression [17]
Ankyrin repeat domain-containing protein 36A (ANKRD36) OT3XEYKG AN36A_HUMAN Increases Expression [17]
Pyridoxal kinase (PDXK) OT40AJ5J PDXK_HUMAN Decreases Expression [17]
Inositol monophosphatase 2 (IMPA2) OTNFB9YN IMPA2_HUMAN Increases Expression [17]
Proepiregulin (EREG) OTRM4NQY EREG_HUMAN Decreases Expression [17]
Microtubule-associated serine/threonine-protein kinase 4 (MAST4) OT3LOE2J MAST4_HUMAN Increases Expression [17]
Monocarboxylate transporter 7 (SLC16A6) OT7BIIZX MOT7_HUMAN Increases Expression [17]
Nucleoplasmin-3 (NPM3) OTIAM1A3 NPM3_HUMAN Decreases Expression [17]
Ubiquitin-like protein ATG12 (ATG12) OTJRO09Y ATG12_HUMAN Decreases Expression [17]
Fibroblast growth factor 2 (FGF2) OT7YUJ9F FGF2_HUMAN Decreases Expression [17]
Microtubule-associated protein 2 (MAP2) OT6UYT3X MTAP2_HUMAN Increases Expression [17]
Ribose-phosphate pyrophosphokinase 2 (PRPS2) OTCY1B1O PRPS2_HUMAN Decreases Expression [17]
Tissue factor (F3) OT3MSU3B TF_HUMAN Decreases Expression [17]
Folate receptor alpha (FOLR1) OT0QZ0H6 FOLR1_HUMAN Decreases Expression [17]
Calretinin (CALB2) OTSNMCG9 CALB2_HUMAN Increases Expression [17]
Signal transducer CD24 (CD24) OT7CODJ4 CD24_HUMAN Increases Expression [17]
M-phase inducer phosphatase 1 (CDC25A) OTSLKKCO MPIP1_HUMAN Decreases Expression [17]
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (MAN1A1) OT6LIGJP MA1A1_HUMAN Increases Expression [17]
Proteasome subunit beta type-10 (PSMB10) OTURUR9B PSB10_HUMAN Decreases Expression [17]
Regulator of G-protein signaling 2 (RGS2) OT0FSRW7 RGS2_HUMAN Decreases Expression [17]
Nuclear receptor-interacting protein 1 (NRIP1) OTIZOJQV NRIP1_HUMAN Decreases Expression [17]
CCN family member 3 (CCN3) OTOW5YL4 CCN3_HUMAN Increases Expression [17]
Caveolin-2 (CAV2) OT1FGRQX CAV2_HUMAN Decreases Expression [17]
ADP-ribosylation factor-like protein 4C (ARL4C) OTQ3QNNU ARL4C_HUMAN Increases Expression [17]
Transmembrane protein 33 (TMEM33) OTRG1DOY TMM33_HUMAN Decreases Expression [17]
Epiplakin (EPPK1) OT7BAU8C EPIPL_HUMAN Increases Expression [17]
Triosephosphate isomerase (TPI1) OT14KP4B TPIS_HUMAN Decreases Expression [17]
Protein jagged-1 (JAG1) OT3LGT6K JAG1_HUMAN Increases Expression [17]
High mobility group nucleosome-binding domain-containing protein 5 (HMGN5) OTUUAHVQ HMGN5_HUMAN Increases Expression [17]
Small EDRK-rich factor 2 (SERF2) OTZQDYCZ SERF2_HUMAN Decreases Expression [17]
Transcription factor SOX-4 (SOX4) OTSS40SS SOX4_HUMAN Increases Expression [17]
Proline-rich nuclear receptor coactivator 1 (PNRC1) OTQMLEE1 PNRC1_HUMAN Increases Expression [17]
S-methyl-5'-thioadenosine phosphorylase (MTAP) OTOWN2K9 MTAP_HUMAN Decreases Expression [17]
Spliceosome RNA helicase DDX39B (DDX39B) OTEVCFVU DX39B_HUMAN Increases Expression [17]
Beta-1-syntrophin (SNTB1) OTSRBECI SNTB1_HUMAN Increases Expression [17]
Transcription factor Dp-1 (TFDP1) OT6RZ7VT TFDP1_HUMAN Decreases Expression [17]
Semaphorin-3A (SEMA3A) OTQJSV7W SEM3A_HUMAN Increases Expression [17]
Uncharacterized protein KIAA0040 (KIAA0040) OT27EBY3 K0040_HUMAN Increases Expression [17]
Cyclin-G2 (CCNG2) OTII38K2 CCNG2_HUMAN Increases Expression [17]
Dual specificity protein phosphatase 6 (DUSP6) OT4H6RKW DUS6_HUMAN Increases Expression [17]
Pre-rRNA-processing protein TSR1 homolog (TSR1) OTCVZFL9 TSR1_HUMAN Decreases Expression [17]
Fibronectin type III domain-containing protein 3B (FNDC3B) OTBILGDR FND3B_HUMAN Decreases Expression [17]
Nucleolar MIF4G domain-containing protein 1 (NOM1) OTWZSJJC NOM1_HUMAN Decreases Expression [17]
Protein FAM76B (FAM76B) OT4RG5U7 FA76B_HUMAN Decreases Expression [17]
MAGUK p55 subfamily member 7 (MPP7) OT3G3HTZ MPP7_HUMAN Decreases Expression [17]
U11/U12 small nuclear ribonucleoprotein 48 kDa protein (SNRNP48) OTSR6DEJ SNR48_HUMAN Decreases Expression [17]
Parafibromin (CDC73) OT6JASZ1 CDC73_HUMAN Decreases Expression [17]
Neuroblastoma breakpoint family member 10 (NBPF10) OTGOCELY NBPFA_HUMAN Increases Expression [17]
Kelch-like protein 24 (KLHL24) OTWZSX5C KLH24_HUMAN Increases Expression [17]
Ankyrin repeat domain-containing protein 11 (ANKRD11) OTV0V70M ANR11_HUMAN Increases Expression [17]
MAM domain-containing protein 2 (MAMDC2) OT4GICNY MAMC2_HUMAN Increases Expression [17]
Coiled-coil domain-containing protein 186 (CCDC186) OTONSQAD CC186_HUMAN Increases Expression [17]
Serologically defined colon cancer antigen 8 (SDCCAG8) OTV2ZGV9 SDCG8_HUMAN Increases Expression [17]
Liprin-beta-1 (PPFIBP1) OTRA2S7B LIPB1_HUMAN Increases Expression [17]
Homeobox protein Mohawk (MKX) OT7H7Z50 MKX_HUMAN Decreases Expression [17]
Mastermind-like protein 2 (MAML2) OT1TSVAR MAML2_HUMAN Increases Expression [17]
Delta and Notch-like epidermal growth factor-related receptor (DNER) OT2GH2E5 DNER_HUMAN Increases Expression [17]
Ribosome biogenesis protein BRX1 homolog (BRIX1) OTQ5F1D1 BRX1_HUMAN Decreases Expression [17]
Tribbles homolog 2 (TRIB2) OTHSX3MX TRIB2_HUMAN Increases Expression [17]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1) OT2363Z9 T53I1_HUMAN Increases Expression [17]
Alkylated DNA repair protein alkB homolog 8 (ALKBH8) OTXN70DV ALKB8_HUMAN Decreases Expression [17]
EF-hand domain-containing protein D2 (EFHD2) OTM9VMN3 EFHD2_HUMAN Decreases Expression [17]
H/ACA ribonucleoprotein complex non-core subunit NAF1 (NAF1) OTMJKJAK NAF1_HUMAN Decreases Expression [17]
Heparan-sulfate 6-O-sulfotransferase 2 (HS6ST2) OT8A3H9Y H6ST2_HUMAN Decreases Expression [17]
Transmembrane protein 74 (TMEM74) OT3IZBM0 TMM74_HUMAN Increases Expression [17]
Small integral membrane protein 14 (SMIM14) OT47IF19 SIM14_HUMAN Increases Expression [17]
Peptide deformylase, mitochondrial (PDF) OTZ75ZK5 DEFM_HUMAN Increases Expression [17]
Synaptotagmin-like protein 2 (SYTL2) OTUIOWKL SYTL2_HUMAN Increases Expression [17]
Uncharacterized protein C14orf132 (C14ORF132) OTBVC3AO CN132_HUMAN Increases Expression [17]
Cell death regulator Aven (AVEN) OTGIN5YK AVEN_HUMAN Decreases Expression [17]
DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C) OTPL0AI1 ABC3C_HUMAN Increases Expression [17]
DNA damage-inducible transcript 4 protein (DDIT4) OTHY8SY4 DDIT4_HUMAN Increases Expression [17]
Cysteine-rich motor neuron 1 protein (CRIM1) OTTZNV6Y CRIM1_HUMAN Decreases Expression [17]
Protein DBF4 homolog A (DBF4) OTBL7JHQ DBF4A_HUMAN Decreases Expression [17]
Pleckstrin homology domain-containing family B member 1 (PLEKHB1) OTC7TNAX PKHB1_HUMAN Increases Expression [17]
Switch-associated protein 70 (SWAP70) OTPHT2QD SWP70_HUMAN Decreases Expression [17]
Carboxypeptidase A4 (CPA4) OT66MP0F CBPA4_HUMAN Decreases Expression [17]
Endoribonuclease Dicer (DICER1) OTTVSEY0 DICER_HUMAN Decreases Expression [17]
RRP15-like protein (RRP15) OTE8CQ7K RRP15_HUMAN Decreases Expression [17]
AP-4 complex subunit sigma-1 (AP4S1) OTM3QBU8 AP4S1_HUMAN Decreases Expression [17]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) OTQ4W7MT TR11B_HUMAN Increases Expression [18]
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2) OTKOZRZP PLOD2_HUMAN Decreases Expression [18]
Nuclear factor 1 B-type (NFIB) OTX94PD0 NFIB_HUMAN Decreases Expression [18]
Apoptotic protease-activating factor 1 (APAF1) OTJWIVY0 APAF_HUMAN Increases Expression [18]
Suppressor of cytokine signaling 1 (SOCS1) OTWA9KFU SOCS1_HUMAN Increases Expression [18]
Krueppel-like factor 4 (KLF4) OT4O9RQW KLF4_HUMAN Increases Expression [18]
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) OT8KME51 BUB1B_HUMAN Decreases Expression [18]
Cell division control protein 45 homolog (CDC45) OT6NNLOD CDC45_HUMAN Affects Expression [18]
Transcription factor Maf (MAF) OT1GR3IZ MAF_HUMAN Increases Expression [18]
G2/mitotic-specific cyclin-B2 (CCNB2) OTIEXTDK CCNB2_HUMAN Decreases Expression [18]
Fibrinogen silencer-binding protein (RAD54B) OTMWB2P2 FSBP_HUMAN Decreases Expression [18]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [18]
GTPase HRas (HRAS) OTWQN0DP RASH_HUMAN Increases Expression [18]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Increases Expression [18]
Thymidine kinase, cytosolic (TK1) OTY5JFM1 KITH_HUMAN Affects Expression [18]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Expression [18]
Transcriptional activator Myb (MYB) OTJH64IV MYB_HUMAN Decreases Expression [18]
Myb-related protein B (MYBL2) OTZ3JX8Q MYBB_HUMAN Increases Expression [18]
Proliferating cell nuclear antigen (PCNA) OTHZ1RIA PCNA_HUMAN Increases Expression [18]
Transcription factor JunB (JUNB) OTG2JXV5 JUNB_HUMAN Increases Expression [18]
CCAAT/enhancer-binding protein beta (CEBPB) OTM9MQIA CEBPB_HUMAN Increases Expression [18]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Increases Expression [18]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) OTVLI4DD TNAP3_HUMAN Increases Expression [18]
Insulin-like growth factor-binding protein 5 (IGFBP5) OTRE5V0C IBP5_HUMAN Decreases Expression [18]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Increases Expression [18]
Lysine-specific demethylase 5A (KDM5A) OTLYFX8A KDM5A_HUMAN Decreases Expression [18]
2'-5'-oligoadenylate synthase 2 (OAS2) OT64CCTM OAS2_HUMAN Increases Expression [18]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2) OTOB6J6R RIR2_HUMAN Decreases Expression [18]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Increases Expression [18]
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (DUT) OT0THBVA DUT_HUMAN Decreases Expression [18]
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Increases Expression [18]
DNA-binding protein inhibitor ID-1 (ID1) OTKGNZN5 ID1_HUMAN Increases Expression [18]
Protein phosphatase inhibitor 2 (PPP1R2) OTNLOUQR IPP2_HUMAN Decreases Expression [18]
Cyclin-dependent kinase 4 inhibitor C (CDKN2C) OTCLOV90 CDN2C_HUMAN Decreases Expression [18]
DNA mismatch repair protein Msh2 (MSH2) OT10H1AB MSH2_HUMAN Decreases Expression [18]
Histone deacetylase 4 (HDAC4) OTQNGD32 HDAC4_HUMAN Decreases Expression [18]
Protein S100-A10 (S100A10) OTI71243 S10AA_HUMAN Increases Expression [18]
Large ribosomal subunit protein eL37 (RPL37) OTB6SDZ1 RL37_HUMAN Decreases Expression [18]
Fanconi anemia group C protein (FANCC) OTTIDM3P FANCC_HUMAN Decreases Expression [18]
DNA-binding protein inhibitor ID-2 (ID2) OT0U1D53 ID2_HUMAN Increases Expression [18]
Transforming growth factor beta receptor type 3 (TGFBR3) OTQOOUC4 TGBR3_HUMAN Increases Expression [18]
Histone-binding protein RBBP4 (RBBP4) OTG3BT3M RBBP4_HUMAN Decreases Expression [18]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Increases Expression [18]
Ribosomal protein eS27-like (RPS27L) OTZWHU0N RS27L_HUMAN Increases Expression [18]
Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B) OTE8GBUR RIR2B_HUMAN Increases Expression [18]
Pantothenate kinase 1 (PANK1) OT2CZVRT PANK1_HUMAN Increases Expression [18]
Cullin-5 (CUL5) OTMTZD47 CUL5_HUMAN Increases Expression [18]
RNA-binding protein 14 (RBM14) OTO9GMBD RBM14_HUMAN Increases Expression [18]
Endothelial PAS domain-containing protein 1 (EPAS1) OTRE3O8U EPAS1_HUMAN Increases Expression [18]
Target of rapamycin complex 2 subunit MAPKAP1 (MAPKAP1) OTYKB9G3 SIN1_HUMAN Increases Expression [18]
E3 ubiquitin-protein ligase SMURF1 (SMURF1) OT5UIZR8 SMUF1_HUMAN Increases Expression [18]
Diablo IAP-binding mitochondrial protein (DIABLO) OTHJ9MCZ DBLOH_HUMAN Increases Expression [18]
SERTA domain-containing protein 1 (SERTAD1) OTBHKZQP SRTD1_HUMAN Increases Expression [18]
Heat shock protein beta-8 (HSPB8) OT0I83YS HSPB8_HUMAN Increases Expression [18]
F-box only protein 5 (FBXO5) OTTR957W FBX5_HUMAN Decreases Expression [18]
Pleckstrin homology-like domain family A member 3 (PHLDA3) OTXFUDO2 PHLA3_HUMAN Increases Expression [18]
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18) OTCW8HT6 TNR18_HUMAN Increases Expression [18]
Regulator of G-protein signaling 13 (RGS13) OTPAMQ18 RGS13_HUMAN Decreases Expression [19]
Pre-mRNA-processing factor 17 (CDC40) OTOYUNHN PRP17_HUMAN Increases Expression [19]
Synaptosomal-associated protein 29 (SNAP29) OTT30ZON SNP29_HUMAN Increases Expression [19]
Protein phosphatase 1 regulatory subunit 17 (PPP1R17) OT19635T PPR17_HUMAN Increases Expression [19]
RAC-beta serine/threonine-protein kinase (AKT2) OTBB632K AKT2_HUMAN Increases Expression [19]
Serpin B4 (SERPINB4) OT88LHZ8 SPB4_HUMAN Decreases Expression [19]
Cullin-4B (CUL4B) OT2QX4DO CUL4B_HUMAN Increases Expression [19]
TRAF family member-associated NF-kappa-B activator (TANK) OTZSGFIK TANK_HUMAN Increases Expression [19]
Engulfment and cell motility protein 2 (ELMO2) OTKDOC2M ELMO2_HUMAN Increases Expression [19]
Mitotic spindle assembly checkpoint protein MAD2B (MAD2L2) OT24ZO59 MD2L2_HUMAN Decreases Expression [19]
Peptidyl-prolyl cis-trans isomerase E (PPIE) OTIE5OAD PPIE_HUMAN Increases Expression [19]
Transmembrane gamma-carboxyglutamic acid protein 1 (PRRG1) OTMH6OWG TMG1_HUMAN Decreases Expression [20]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Increases Expression [20]
Protein sprouty homolog 1 (SPRY1) OT764FXI SPY1_HUMAN Increases Expression [20]
Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) OTRNDZXB HNRPQ_HUMAN Decreases Expression [20]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Increases Expression [20]
Fibrinogen gamma chain (FGG) OT5BJSEX FIBG_HUMAN Decreases Expression [20]
Plasma serine protease inhibitor (SERPINA5) OTTZXPGD IPSP_HUMAN Increases Expression [20]
Interferon alpha-inducible protein 6 (IFI6) OTWOOAM4 IFI6_HUMAN Increases Expression [20]
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) OTXOQDSG IFIT1_HUMAN Increases Expression [20]
Annexin A3 (ANXA3) OTDD8OI7 ANXA3_HUMAN Increases Expression [20]
Early growth response protein 1 (EGR1) OTCP6XGZ EGR1_HUMAN Decreases Expression [20]
Fibulin-1 (FBLN1) OT5MHHOP FBLN1_HUMAN Increases Expression [20]
Myristoylated alanine-rich C-kinase substrate (MARCKS) OT7N056G MARCS_HUMAN Decreases Expression [20]
Lysophosphatidic acid receptor 6 (LPAR6) OT4BY3W4 LPAR6_HUMAN Decreases Expression [20]
Eukaryotic translation initiation factor 5 (EIF5) OT79PQUN IF5_HUMAN Increases Expression [20]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) OTOWDUNT PTEN_HUMAN Decreases Expression [20]
Ras-related protein Rab-11A (RAB11A) OTC4FW0J RB11A_HUMAN Decreases Expression [20]
Histone H4 (H4C1) OTB71W46 H4_HUMAN Decreases Expression [20]
Metallothionein-1X (MT1X) OT9AKFVS MT1X_HUMAN Decreases Expression [20]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) OTXNGZCG MD2L1_HUMAN Decreases Expression [20]
Baculoviral IAP repeat-containing protein 2 (BIRC2) OTFXFREP BIRC2_HUMAN Increases Expression [20]
Four and a half LIM domains protein 3 (FHL3) OTMPRLZ5 FHL3_HUMAN Increases Expression [20]
PCNA-associated factor (PCLAF) OTMVIOUU PAF15_HUMAN Decreases Expression [20]
Ankyrin repeat domain-containing protein 1 (ANKRD1) OTHJ7JV9 ANKR1_HUMAN Increases Expression [20]
Adipogenesis regulatory factor (ADIRF) OTTJP8D4 ADIRF_HUMAN Increases Expression [20]
Protein mono-ADP-ribosyltransferase PARP14 (PARP14) OTFXJAKK PAR14_HUMAN Increases Expression [20]
Centrosomal protein of 55 kDa (CEP55) OTGSG2PA CEP55_HUMAN Decreases Expression [20]
ATP-dependent RNA helicase SUPV3L1, mitochondrial (SUPV3L1) OT416O2G SUV3_HUMAN Decreases Expression [20]
Membrane progestin receptor beta (PAQR8) OTGZ8W9F PAQR8_HUMAN Decreases Expression [20]
Programmed cell death 6-interacting protein (PDCD6IP) OTS8T6A7 PDC6I_HUMAN Decreases Expression [20]
BTB/POZ domain-containing protein KCTD12 (KCTD12) OTPYKT4Z KCD12_HUMAN Decreases Expression [20]
Cytoplasmic FMR1-interacting protein 2 (CYFIP2) OTCAY35T CYFP2_HUMAN Increases Expression [20]
Cell division control protein 6 homolog (CDC6) OTX93FE7 CDC6_HUMAN Decreases Expression [20]
Mini-chromosome maintenance complex-binding protein (MCMBP) OTQ6WO7A MCMBP_HUMAN Increases Expression [20]
Netrin-4 (NTN4) OTDRRMP3 NET4_HUMAN Increases Expression [20]
Serine/threonine-protein kinase Nek6 (NEK6) OT8PQSO1 NEK6_HUMAN Decreases Expression [20]
Stearoyl-CoA desaturase (SCD) OTB1073G SCD_HUMAN Decreases Expression [21]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Increases Expression [21]
Protein phosphatase 1D (PPM1D) OT8NLZ9D PPM1D_HUMAN Increases Expression [21]
TP53-regulated inhibitor of apoptosis 1 (TRIAP1) OTEAUJXN TRIA1_HUMAN Increases Expression [21]
Glutathione peroxidase 1 (GPX1) OTE2O72Q GPX1_HUMAN Increases Expression [21]
Protein S100-A2 (S100A2) OTTGHJ1H S10A2_HUMAN Increases Expression [21]
Serpin B5 (SERPINB5) OTSMXQRJ SPB5_HUMAN Increases Expression [21]
Cyclin-dependent kinase inhibitor 2A (CDKN2A) OTN0ZWAE CDN2A_HUMAN Decreases Expression [21]
Elongation factor 1-alpha 1 (EEF1A1) OT00THXS EF1A1_HUMAN Increases Expression [21]
Protein BTG2 (BTG2) OTZF6K1H BTG2_HUMAN Increases Expression [21]
Antigen peptide transporter 1 (TAP1) OTJL27PW TAP1_HUMAN Increases Expression [21]
Quinone oxidoreductase (CRYZ) OTD2F4C8 QOR_HUMAN Decreases Expression [21]
Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) OTVFQEPA IKIP_HUMAN Increases Expression [21]
DNA damage-regulated autophagy modulator protein 1 (DRAM1) OTIJTXEN DRAM1_HUMAN Increases Expression [21]
Protein ECT2 (ECT2) OTQDUCT6 ECT2_HUMAN Decreases Expression [21]
Anillin (ANLN) OTXJY54C ANLN_HUMAN Decreases Expression [21]
Serine/threonine-protein kinase PLK2 (PLK2) OTKMJXJ8 PLK2_HUMAN Increases Expression [21]
Sestrin-1 (SESN1) OTSFDZWL SESN1_HUMAN Increases Expression [21]
Proto-oncogene tyrosine-protein kinase Src (SRC) OTETYX40 SRC_HUMAN Increases Phosphorylation [65]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Increases Phosphorylation [65]
Thymidine kinase 2, mitochondrial (TK2) OTS1V4XB KITM_HUMAN Increases Expression [22]
Adenylate cyclase type 9 (ADCY9) OT1IZT5K ADCY9_HUMAN Decreases Expression [22]
DNA polymerase alpha catalytic subunit (POLA1) OT1WXFVY DPOLA_HUMAN Decreases Expression [22]
Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) OTPG0K7E IMDH2_HUMAN Increases Expression [22]
CTP synthase 1 (CTPS1) OTZ9J6ZG PYRG1_HUMAN Decreases Expression [22]
Trifunctional purine biosynthetic protein adenosine-3 (GART) OT01JWJB PUR2_HUMAN Increases Expression [22]
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) OTMZN747 PUR6_HUMAN Increases Expression [22]
Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1) OT6E2OW6 ENTP1_HUMAN Decreases Expression [22]
AMP deaminase 2 (AMPD2) OTBS30JU AMPD2_HUMAN Decreases Expression [22]
Guanylate cyclase soluble subunit beta-1 (GUCY1B1) OTSHPHVB GCYB1_HUMAN Decreases Expression [22]
5'(3')-deoxyribonucleotidase, mitochondrial (NT5M) OTJF73BA NT5M_HUMAN Increases Expression [22]
Protein shisa-9 (SHISA9) OTZI2V0J SHSA9_HUMAN Increases Expression [23]
Transmembrane protein 150C (TMEM150C) OTUNPHV7 T150C_HUMAN Decreases Expression [23]
Left-right determination factor 2 (LEFTY2) OT3RX4QF LFTY2_HUMAN Decreases Expression [23]
Fatty acid-binding protein, brain (FABP7) OTRE2H4G FABP7_HUMAN Decreases Expression [23]
Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) OTMVHF9E LGR5_HUMAN Decreases Expression [23]
Cerberus (CER1) OTTAJJ63 CER1_HUMAN Decreases Expression [23]
Urokinase-type plasminogen activator (PLAU) OTX0QGKK UROK_HUMAN Increases Expression [23]
Collagen alpha-1(II) chain (COL2A1) OT5E59C8 CO2A1_HUMAN Decreases Expression [23]
Proto-oncogene DBL (MCF2) OTB9N93T MCF2_HUMAN Increases Expression [23]
Myosin light chain 4 (MYL4) OTURFCSE MYL4_HUMAN Decreases Expression [23]
Protein Cripto (CRIPTO) OT46DZXJ TDGF1_HUMAN Decreases Expression [23]
Secretogranin-2 (SCG2) OTUHXX8U SCG2_HUMAN Increases Expression [23]
Hepatocyte growth factor (HGF) OTGHUA23 HGF_HUMAN Increases Expression [23]
Homeobox protein Hox-B3 (HOXB3) OT9UC5PE HXB3_HUMAN Decreases Expression [23]
5'-nucleotidase (NT5E) OT7J5LT6 5NTD_HUMAN Increases Expression [23]
Endothelin receptor type B (EDNRB) OTLLZV3P EDNRB_HUMAN Decreases Expression [23]
Stomatin (STOM) OTC8R6EH STOM_HUMAN Decreases Expression [23]
Metalloproteinase inhibitor 3 (TIMP3) OTDGQAD1 TIMP3_HUMAN Increases Expression [23]
Glioma pathogenesis-related protein 1 (GLIPR1) OT0FGQK7 GLIP1_HUMAN Increases Expression [23]
LIM/homeobox protein Lhx1 (LHX1) OT6WI2XS LHX1_HUMAN Decreases Expression [23]
Homeobox protein Hox-A1 (HOXA1) OTMSOJ7D HXA1_HUMAN Decreases Expression [23]
Paired mesoderm homeobox protein 1 (PRRX1) OTTZK5G8 PRRX1_HUMAN Decreases Expression [23]
Cadherin-6 (CDH6) OT81Y80S CADH6_HUMAN Decreases Expression [23]
Heart- and neural crest derivatives-expressed protein 2 (HAND2) OTCXYW4Y HAND2_HUMAN Increases Expression [23]
Protein delta homolog 1 (DLK1) OTE1VLNB DLK1_HUMAN Increases Expression [23]
POU domain, class 5, transcription factor 1 (POU5F1) OTDHHN7O PO5F1_HUMAN Decreases Expression [23]
Caveolin-1 (CAV1) OTEZUR1L CAV1_HUMAN Increases Expression [23]
Testican-1 (SPOCK1) OTLTDGK7 TICN1_HUMAN Increases Expression [23]
EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) OTZVUOOB FBLN3_HUMAN Increases Expression [23]
Protein ABHD12B (ABHD12B) OTBHGWTF AB12B_HUMAN Decreases Expression [23]
Secreted frizzled-related protein 2 (SFRP2) OT8GZ0CA SFRP2_HUMAN Decreases Expression [23]
Protein LRATD1 (LRATD1) OT65IL83 LRAT1_HUMAN Increases Expression [23]
Neuroserpin (SERPINI1) OTUJHIJW NEUS_HUMAN Increases Expression [23]
Homeobox protein CDX-2 (CDX2) OTCG4TSY CDX2_HUMAN Decreases Expression [23]
G-protein coupled receptor 87 (GPR87) OTQX45UM GPR87_HUMAN Increases Expression [23]
Homeobox protein Hox-D1 (HOXD1) OTN4V9ZF HXD1_HUMAN Decreases Expression [23]
Transcription factor SOX-17 (SOX17) OT9H4WWE SOX17_HUMAN Decreases Expression [23]
Homeobox protein NANOG (NANOG) OTUEY1FM NANOG_HUMAN Decreases Expression [23]
Tumor necrosis factor receptor superfamily member 19 (TNFRSF19) OTTVT4MB TNR19_HUMAN Decreases Expression [23]
Dynein axonemal heavy chain 2 (DNAH2) OT7J5LDI DYH2_HUMAN Decreases Expression [23]
Histone deacetylase 9 (HDAC9) OTO8O0LF HDAC9_HUMAN Increases Expression [23]
Thrombospondin type-1 domain-containing protein 7A (THSD7A) OT7249HH THS7A_HUMAN Increases Expression [23]
Nuclear factor erythroid 2-related factor 3 (NFE2L3) OT1MGXT0 NF2L3_HUMAN Increases Expression [23]
Transcription factor E2F8 (E2F8) OTQKZGFP E2F8_HUMAN Affects Expression [25]
Aquaporin-12B (AQP12B) OTNU5Z4K AQ12B_HUMAN Decreases Expression [24]
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) OTBPCU2O TR10A_HUMAN Increases Expression [66]
DNA fragmentation factor subunit alpha (DFFA) OTFPFMT8 DFFA_HUMAN Decreases Expression [24]
Forkhead box protein N3 (FOXN3) OTOJYJZP FOXN3_HUMAN Decreases Expression [26]
Butyrophilin subfamily 3 member A3 (BTN3A3) OTKMSJRA BT3A3_HUMAN Increases Expression [34]
Cytochrome c oxidase subunit NDUFA4 (NDUFA4) OTDVH3QG NDUA4_HUMAN Affects Expression [24]
Importin subunit alpha-4 (KPNA3) OTLI3TM2 IMA4_HUMAN Decreases Expression [30]
CCN family member 1 (CCN1) OTKJBEMD CCN1_HUMAN Increases Expression [67]
Pirin (PIR) OT8ALXHU PIR_HUMAN Decreases Expression [26]
Claudin-4 (CLDN4) OT9C4PZ4 CLD4_HUMAN Decreases Expression [26]
Succinate dehydrogenase cytochrome b small subunit, mitochondrial (SDHD) OTYZ8XRH DHSD_HUMAN Affects Expression [24]
Acyl carrier protein, mitochondrial (NDUFAB1) OTF906UR ACPM_HUMAN Affects Expression [24]
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT) OTZX703K CDIPT_HUMAN Affects Expression [25]
Serine/threonine-protein kinase Chk1 (CHEK1) OTTTI622 CHK1_HUMAN Increases Expression [68]
Tripeptidyl-peptidase 1 (TPP1) OT2LQ771 TPP1_HUMAN Affects Expression [25]
Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C) OTVHOL9B TR10C_HUMAN Increases Expression [69]
Ras-related protein M-Ras (MRAS) OTNCVCQW RASM_HUMAN Affects Expression [25]
Tax1-binding protein 3 (TAX1BP3) OTQ6IB4T TX1B3_HUMAN Increases Expression [30]
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) OT9RDS3H IKKB_HUMAN Decreases Expression [70]
Angiopoietin-2 (ANGPT2) OTEQK65P ANGP2_HUMAN Decreases Expression [71]
Actin-related protein 2/3 complex subunit 3 (ARPC3) OTKWVF8P ARPC3_HUMAN Decreases Expression [30]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [30]
Toll-like receptor 3 (TLR3) OT8QPYXZ TLR3_HUMAN Increases Expression [72]
Melanoma-associated antigen B2 (MAGEB2) OTAGUVU5 MAGB2_HUMAN Decreases Expression [26]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Decreases Expression [73]
ATP-dependent RNA helicase DHX15 (DHX15) OT4F98TK DHX15_HUMAN Increases Expression [25]
Prominin-1 (PROM1) OTBHV8NX PROM1_HUMAN Increases Expression [26]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Increases Expression [74]
Zinc finger protein SNAI2 (SNAI2) OT7Y8EJ2 SNAI2_HUMAN Increases Expression [27]
Protein regulator of cytokinesis 1 (PRC1) OTHD0XS0 PRC1_HUMAN Decreases Expression [75]
NADH dehydrogenase 1 subunit C1, mitochondrial (NDUFC1) OTJ5TNHB NDUC1_HUMAN Affects Expression [24]
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1) OT80DZMT BUB1_HUMAN Decreases Expression [30]
Keratin, type II cuticular Hb6 (KRT86) OT93MMAK KRT86_HUMAN Decreases Expression [26]
Aldo-keto reductase family 1 member B10 (AKR1B10) OTOA4HTH AK1BA_HUMAN Affects Expression [25]
Nuclear protein 1 (NUPR1) OT4FU8C0 NUPR1_HUMAN Affects Expression [25]
Serine protease inhibitor Kazal-type 4 (SPINK4) OTHTCW94 ISK4_HUMAN Affects Expression [25]
Cystatin-8 (CST8) OTT2FRCJ CST8_HUMAN Affects Expression [25]
Histone H2B type 1-K (H2BC12) OTQ8V0KG H2B1K_HUMAN Decreases Expression [34]
Receptor activity-modifying protein 1 (RAMP1) OT7UT2XB RAMP1_HUMAN Decreases Expression [26]
Sodium channel subunit beta-2 (SCN2B) OTFAHJ38 SCN2B_HUMAN Affects Expression [25]
Probable phospholipid-transporting ATPase IIA (ATP9A) OT328F1L ATP9A_HUMAN Decreases Expression [26]
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1) OTY9R6FZ ERN1_HUMAN Increases Expression [76]
Breast cancer anti-estrogen resistance protein 3 (BCAR3) OTPJ17M8 BCAR3_HUMAN Decreases Expression [26]
Tumor necrosis factor ligand superfamily member 13 (TNFSF13) OT90OWIO TNF13_HUMAN Increases Expression [77]
Signal recognition particle subunit SRP72 (SRP72) OTPV73W7 SRP72_HUMAN Increases Expression [25]
Cystatin-F (CST7) OTQWZUVQ CYTF_HUMAN Decreases Expression [26]
Dickkopf-related protein 1 (DKK1) OTRDLUSP DKK1_HUMAN Decreases Expression [26]
Tight junction protein ZO-3 (TJP3) OTC1K8HC ZO3_HUMAN Affects Expression [25]
Mitofusin-2 (MFN2) OTPYN8A3 MFN2_HUMAN Increases Expression [78]
NADH dehydrogenase 1 beta subcomplex subunit 2, mitochondrial (NDUFB2) OT4717TF NDUB2_HUMAN Increases Expression [24]
RCC1 and BTB domain-containing protein 2 (RCBTB2) OTECBF4R RCBT2_HUMAN Affects Expression [25]
ATP-binding cassette sub-family C member 6 (ABCC6) OTZT0LKT MRP6_HUMAN Increases Expression [26]
Phenylalanine--tRNA ligase, mitochondrial (FARS2) OTXAK6F0 SYFM_HUMAN Decreases Expression [34]
Double-stranded RNA-binding protein Staufen homolog 1 (STAU1) OTTR5311 STAU1_HUMAN Decreases Expression [30]
Mitochondrial uncoupling protein 4 (SLC25A27) OTSBOPGD UCP4_HUMAN Decreases Expression [24]
NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10) OTFLILEO NDUBA_HUMAN Affects Expression [24]
Glutathione reductase, mitochondrial (GSR) OTM2TUYM GSHR_HUMAN Decreases Activity [79]
Prothrombin (F2) OTNFSM49 THRB_HUMAN Decreases Expression [30]
Coagulation factor XII (F12) OTBFD2FU FA12_HUMAN Decreases Expression [26]
Tissue-type plasminogen activator (PLAT) OTQPDNAB TPA_HUMAN Increases Expression [34]
Thyrotropin subunit beta (TSHB) OTFDI39D TSHB_HUMAN Affects Expression [80]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Increases Expression [81]
Hemoglobin subunit epsilon (HBE1) OTJPKMX4 HBE_HUMAN Decreases Expression [26]
Keratin, type II cytoskeletal 6A (KRT6A) OT392M5T K2C6A_HUMAN Affects Expression [25]
Prelamin-A/C (LMNA) OT3SG7ZR LMNA_HUMAN Increases Cleavage [82]
Apolipoprotein C-III (APOC3) OTW3520C APOC3_HUMAN Decreases Expression [76]
Metallothionein-2 (MT2A) OTHOACHD MT2_HUMAN Decreases Expression [33]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Increases Expression [81]
Catalase (CAT) OTHEBX9R CATA_HUMAN Decreases Activity [79]
Vitamin K-dependent protein C (PROC) OTGVH484 PROC_HUMAN Decreases Activity [83]
Annexin A1 (ANXA1) OT5OFDJC ANXA1_HUMAN Decreases Expression [26]
Apolipoprotein B-100 (APOB) OTH0UOCZ APOB_HUMAN Decreases Expression [76]
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) OTBPMIMW G3P_HUMAN Affects Splicing [84]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Decreases Expression [30]
Metallothionein-1E (MT1E) OTXJKU4Y MT1E_HUMAN Increases Expression [26]
Integrin beta-2 (ITGB2) OTEKPEPR ITB2_HUMAN Decreases Expression [85]
Plasminogen activator inhibitor 2 (SERPINB2) OT72QLZB PAI2_HUMAN Increases Expression [30]
Ubiquitin-like protein ISG15 (ISG15) OT53QQ7N ISG15_HUMAN Increases Expression [34]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) OTM0GDTP IF2A_HUMAN Increases Phosphorylation [86]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Increases Expression [87]
Endothelin-1 (EDN1) OTZCACEG EDN1_HUMAN Increases Expression [88]
Keratin, type I cytoskeletal 18 (KRT18) OTVLQFIP K1C18_HUMAN Affects Expression [24]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Increases Phosphorylation [89]
Progesterone receptor (PGR) OT0FZ3QE PRGR_HUMAN Affects Expression [24]
Eukaryotic translation initiation factor 4E (EIF4E) OTDAWNLA IF4E_HUMAN Increases Expression [25]
Protein disulfide-isomerase (P4HB) OTTYNYPF PDIA1_HUMAN Decreases Expression [76]
Trypsin-2 (PRSS2) OTOMVUWL TRY2_HUMAN Affects Expression [25]
Bifunctional glutamate/proline--tRNA ligase (EPRS1) OTXK0FLB SYEP_HUMAN Decreases Expression [30]
Cathepsin B (CTSB) OTP9G5QB CATB_HUMAN Increases Cleavage [90]
DNA excision repair protein ERCC-1 (ERCC1) OTNPYQHI ERCC1_HUMAN Decreases Expression [91]
Thrombospondin-1 (THBS1) OT0ECWK3 TSP1_HUMAN Increases Expression [92]
Zinc finger protein GLI1 (GLI1) OT1BTAJO GLI1_HUMAN Decreases Expression [93]
Collagen alpha-2(IV) chain (COL4A2) OTJK1LKN CO4A2_HUMAN Decreases Expression [26]
Nuclear factor 1 C-type (NFIC) OTLMCUIB NFIC_HUMAN Increases Expression [25]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Affects Expression [25]
Keratin, type I cytoskeletal 16 (KRT16) OTGA0EQN K1C16_HUMAN Increases Expression [81]
CD63 antigen (CD63) OT2UGZA9 CD63_HUMAN Decreases Expression [85]
Retinol-binding protein 1 (RBP1) OTRP1MFC RET1_HUMAN Decreases Expression [26]
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) OTIRPN6B ROA1_HUMAN Decreases Expression [34]
Pro-cathepsin H (CTSH) OTLFL0DG CATH_HUMAN Increases Expression [26]
Cytochrome c oxidase subunit 6C (COX6C) OT3V7JE5 COX6C_HUMAN Affects Expression [24]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Expression [31]
Interferon-induced protein with tetratricopeptide repeats 2 (IFIT2) OTI4EOAR IFIT2_HUMAN Increases Expression [34]
Serum amyloid A-1 protein (SAA1) OTO2D8S0 SAA1_HUMAN Increases Expression [34]
Heat shock 70 kDa protein 1A (HSPA1A) OTKGIE76 HS71A_HUMAN Decreases Expression [26]
Small integral membrane protein 10-like protein 2A (SMIM10L2B) OT04IG2N SIL2A_HUMAN Decreases Expression [24]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [87]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [94]
Cytochrome c oxidase subunit 5B, mitochondrial (COX5B) OTDP94F3 COX5B_HUMAN Affects Expression [24]
T-cell surface glycoprotein CD8 beta chain (CD8B) OTMZ1T7J CD8B_HUMAN Decreases Expression [26]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Decreases Expression [76]
DNA topoisomerase 1 (TOP1) OT51O0CF TOP1_HUMAN Decreases Expression [30]
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (BCKDHA) OT0LHOZB ODBA_HUMAN Affects Expression [25]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Decreases Expression [26]
Interferon-induced transmembrane protein 1 (IFITM1) OTECO1G8 IFM1_HUMAN Increases Expression [34]
Platelet glycoprotein Ib beta chain (GP1BB) OTD7XNLL GP1BB_HUMAN Affects Expression [25]
Keratin, type II cytoskeletal 5 (KRT5) OTVGI9HT K2C5_HUMAN Decreases Expression [26]
Protein disulfide-isomerase A4 (PDIA4) OTVFUJ13 PDIA4_HUMAN Decreases Expression [30]
Troponin T, slow skeletal muscle (TNNT1) OT8PBOAR TNNT1_HUMAN Decreases Expression [26]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Increases Expression [27]
Aspartate--tRNA ligase, cytoplasmic (DARS1) OT0WGC2T SYDC_HUMAN Affects Expression [25]
Protein C-ets-1 (ETS1) OT4LVGDN ETS1_HUMAN Increases Expression [70]
Fos-related antigen 1 (FOSL1) OT9YTYMB FOSL1_HUMAN Affects Expression [24]
Amphiregulin (AREG) OTJFOR67 AREG_HUMAN Increases Expression [30]
Transcription factor E2-alpha (TCF3) OTW6FR32 TFE2_HUMAN Affects Expression [24]
Cytochrome c oxidase subunit 7C, mitochondrial (COX7C) OTREWSBF COX7C_HUMAN Affects Expression [24]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Phosphorylation [66]
Methylated-DNA--protein-cysteine methyltransferase (MGMT) OT40A9WH MGMT_HUMAN Decreases Expression [95]
Carboxypeptidase E (CPE) OTXNTV79 CBPE_HUMAN Increases Expression [26]
Interferon alpha/beta receptor 1 (IFNAR1) OTD4OOFK INAR1_HUMAN Increases Expression [96]
HLA class I histocompatibility antigen, alpha chain G (HLA-G) OTMLK1KN HLAG_HUMAN Increases Expression [34]
Regulator of chromosome condensation (RCC1) OT25AGMB RCC1_HUMAN Decreases Expression [30]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Increases Expression [86]
Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6) OTAFHAVI ATF6A_HUMAN Affects Expression [24]
ATP synthase-coupling factor 6, mitochondrial (ATP5PF) OTDAE8FP ATP5J_HUMAN Increases Expression [24]
Nucleolin (NCL) OTBXPKMP NUCL_HUMAN Affects Splicing [84]
Troponin I, cardiac muscle (TNNI3) OT65E12V TNNI3_HUMAN Decreases Expression [26]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) OT2D9DOV TNR1A_HUMAN Affects Expression [24]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Increases Phosphorylation [27]
Lamin-B1 (LMNB1) OT100T3P LMNB1_HUMAN Decreases Expression [24]
Hepatocyte nuclear factor 1-alpha (HNF1A) OT9DOUKL HNF1A_HUMAN Affects Expression [24]
C4b-binding protein beta chain (C4BPB) OTJ70B0K C4BPB_HUMAN Affects Expression [25]
Kit ligand (KITLG) OTB9AVQ4 SCF_HUMAN Increases Expression [88]
Lactoperoxidase (LPO) OTJ9QKX9 PERL_HUMAN Decreases Expression [97]
Cornifin-B (SPRR1B) OTXNW3P6 SPR1B_HUMAN Affects Expression [25]
Paired box protein Pax-3 (PAX3) OTN5PJZV PAX3_HUMAN Decreases Expression [29]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Decreases Expression [98]
ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) OTPOAAUW AT5F1_HUMAN Affects Expression [24]
Insulin-like growth factor-binding protein 6 (IGFBP6) OTW878VI IBP6_HUMAN Decreases Expression [26]
Cyclin-C (CCNC) OTMVK4K4 CCNC_HUMAN Decreases Expression [30]
G1/S-specific cyclin-E1 (CCNE1) OTLD7UID CCNE1_HUMAN Decreases Expression [35]
Cytochrome P450 2F1 (CYP2F1) OTY3HJH1 CP2F1_HUMAN Affects Expression [25]
DNA replication licensing factor MCM3 (MCM3) OTOOHQPM MCM3_HUMAN Decreases Expression [30]
Protein S100-P (S100P) OTJCXNJG S100P_HUMAN Decreases Expression [26]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Decreases Degradation [99]
Paired box protein Pax-6 (PAX6) OTOC9876 PAX6_HUMAN Decreases Expression [78]
Protein S100-A4 (S100A4) OTLRGFSQ S10A4_HUMAN Decreases Expression [26]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Increases Phosphorylation [100]
G0/G1 switch protein 2 (G0S2) OT8FL49L G0S2_HUMAN Increases Expression [26]
Probable global transcription activator SNF2L1 (SMARCA1) OT0Y6PTU SMCA1_HUMAN Increases Expression [26]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Increases Phosphorylation [100]
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) OTG0TTX7 CD38_HUMAN Affects Expression [25]
Tripeptidyl-peptidase 2 (TPP2) OT91OVAU TPP2_HUMAN Affects Localization [101]
Caspase-1 (CASP1) OTZ3YQFU CASP1_HUMAN Increases Cleavage [102]
Cellular retinoic acid-binding protein 1 (CRABP1) OTISDG5X RABP1_HUMAN Increases Expression [26]
ATP synthase subunit delta, mitochondrial (ATP5F1D) OTXTAG2V ATPD_HUMAN Affects Expression [24]
G1/S-specific cyclin-D2 (CCND2) OTDULQF9 CCND2_HUMAN Increases Expression [26]
G1/S-specific cyclin-D3 (CCND3) OTNKPQ22 CCND3_HUMAN Increases Expression [30]
M-phase inducer phosphatase 2 (CDC25B) OT12MSRY MPIP2_HUMAN Decreases Expression [30]
HLA class I histocompatibility antigen, alpha chain F (HLA-F) OT76CM19 HLAF_HUMAN Increases Expression [34]
Adenylosuccinate synthetase isozyme 2 (ADSS2) OTW26XXB PURA2_HUMAN Decreases Expression [30]
Neurotensin receptor type 1 (NTSR1) OTTJUTE3 NTR1_HUMAN Decreases Expression [26]
CAMPATH-1 antigen (CD52) OT02LDQN CD52_HUMAN Affects Expression [25]
Neural cell adhesion molecule L1 (L1CAM) OTNWAQ4Y L1CAM_HUMAN Decreases Expression [26]
Homeobox protein OTX2 (OTX2) OTTV05B1 OTX2_HUMAN Decreases Expression [78]
Cyclin-dependent kinases regulatory subunit 2 (CKS2) OTPTMHIV CKS2_HUMAN Decreases Expression [75]
Protein S100-A3 (S100A3) OTVIZJ2R S10A3_HUMAN Decreases Expression [26]
Heat shock 70 kDa protein 4 (HSPA4) OT5HR0AR HSP74_HUMAN Decreases Expression [26]
5-hydroxytryptamine receptor 7 (HTR7) OT44DEWB 5HT7R_HUMAN Affects Expression [25]
Profilin-2 (PFN2) OT5SSSA7 PROF2_HUMAN Increases Expression [26]
Radixin (RDX) OTNSYUN6 RADI_HUMAN Affects Expression [25]
Cornifin-A (SPRR1A) OTJMI34A SPR1A_HUMAN Increases Expression [25]
Homeobox protein MSX-2 (MSX2) OT1WDKE1 MSX2_HUMAN Decreases Expression [26]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [103]
Sterol regulatory element-binding protein 1 (SREBF1) OTWBRPAI SRBP1_HUMAN Affects Expression [24]
17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2) OT3K7HY5 DHB2_HUMAN Affects Expression [25]
Amiloride-sensitive sodium channel subunit alpha (SCNN1A) OTE2KVZV SCNNA_HUMAN Decreases Expression [26]
Peroxisome proliferator-activated receptor gamma (PPARG) OTHMARHO PPARG_HUMAN Decreases Expression [26]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Decreases Expression [104]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [105]
Hepatocyte nuclear factor 4-alpha (HNF4A) OTY1TOAB HNF4A_HUMAN Affects Expression [24]
Neuroblastoma suppressor of tumorigenicity 1 (NBL1) OTT37U4O NBL1_HUMAN Decreases Expression [30]
Signal transducer and activator of transcription 1-alpha/beta (STAT1) OTLMBUZ6 STAT1_HUMAN Increases Expression [24]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Affects Expression [25]
Serine/threonine-protein kinase mTOR (MTOR) OTHH8KU7 MTOR_HUMAN Decreases Expression [97]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Expression [106]
Caspase-2 (CASP2) OTUDYSPP CASP2_HUMAN Decreases Expression [24]
Melanoma-associated antigen 2 (MAGEA2) OTQ0YOTY MAGA2_HUMAN Decreases Expression [26]
Melanoma-associated antigen 6 (MAGEA6) OTI8S0O2 MAGA6_HUMAN Decreases Expression [26]
Melanoma-associated antigen 12 (MAGEA12) OT8ULELL MAGAC_HUMAN Decreases Expression [26]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Decreases Expression [35]
Retinaldehyde dehydrogenase 3 (ALDH1A3) OT1C9NKQ AL1A3_HUMAN Decreases Expression [26]
Galectin-7 (LGALS7) OTMSVI7R LEG7_HUMAN Decreases Expression [26]
Iron-responsive element-binding protein 2 (IREB2) OT747D24 IREB2_HUMAN Increases Expression [25]
Interferon alpha/beta receptor 2 (IFNAR2) OTBIRNIJ INAR2_HUMAN Increases Expression [34]
Sodium/hydrogen exchanger 3 (SLC9A3) OTZ7PFVT SL9A3_HUMAN Decreases Expression [24]
Caspase-4 (CASP4) OTVQTV1L CASP4_HUMAN Increases Expression [26]
Casein kinase I isoform epsilon (CSNK1E) OTF0UXX6 KC1E_HUMAN Affects Expression [25]
Tuberin (TSC2) OT47LWI9 TSC2_HUMAN Increases Expression [25]
NADH dehydrogenase flavoprotein 1, mitochondrial (NDUFV1) OTEVK4WW NDUV1_HUMAN Affects Expression [24]
Ketohexokinase (KHK) OT153922 KHK_HUMAN Increases Expression [26]
Homeobox protein MOX-1 (MEOX1) OTJEMT2D MEOX1_HUMAN Increases Expression [29]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Increases Expression [107]
Amiloride-sensitive sodium channel subunit beta (SCNN1B) OT61QQTL SCNNB_HUMAN Affects Expression [25]
Serine/threonine-protein kinase Nek4 (NEK4) OTOB8366 NEK4_HUMAN Decreases Expression [30]
Cyclin-G1 (CCNG1) OT17IA9L CCNG1_HUMAN Decreases Expression [30]
Rho-related GTP-binding protein RhoN (RND2) OT98M6UI RND2_HUMAN Increases Expression [34]
Importin subunit alpha-1 (KPNA2) OTU7FOE6 IMA1_HUMAN Decreases Expression [75]
Rho GDP-dissociation inhibitor 2 (ARHGDIB) OT9PD6CS GDIR2_HUMAN Affects Expression [24]
Hexokinase-2 (HK2) OTC0GCQO HXK2_HUMAN Decreases Expression [108]
Ephrin-B2 (EFNB2) OT0DCUOM EFNB2_HUMAN Decreases Expression [26]
Death-associated protein kinase 1 (DAPK1) OTNCNUCO DAPK1_HUMAN Increases Expression [70]
LIM domain kinase 1 (LIMK1) OTFZ8MZ0 LIMK1_HUMAN Affects Expression [24]
Monocarboxylate transporter 1 (SLC16A1) OTW1UTZ7 MOT1_HUMAN Decreases Expression [30]
Heat shock-related 70 kDa protein 2 (HSPA2) OTSDET7B HSP72_HUMAN Increases Expression [34]
Microsomal triglyceride transfer protein large subunit (MTTP) OTNUVSDT MTP_HUMAN Decreases Expression [76]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Increases Expression [24]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Decreases Expression [109]
Caspase-6 (CASP6) OTXLD3EC CASP6_HUMAN Affects Expression [24]
Forkhead box protein G1 (FOXG1) OTAW57J4 FOXG1_HUMAN Decreases Expression [78]
NADH dehydrogenase flavoprotein 3, mitochondrial (NDUFV3) OTSCYB9P NDUV3_HUMAN Increases Expression [24]
NADH dehydrogenase 1 alpha subcomplex subunit 6 (NDUFA6) OTEOIIOL NDUA6_HUMAN Affects Expression [24]
Claudin-2 (CLDN2) OTRF3D6Y CLD2_HUMAN Decreases Expression [27]
Sestrin-2 (SESN2) OT889IXY SESN2_HUMAN Increases Expression [110]
Forkhead box protein L2 (FOXL2) OTFRQUYL FOXL2_HUMAN Increases Expression [24]
Ribose-phosphate pyrophosphokinase 1 (PRPS1) OTN3A6CN PRPS1_HUMAN Increases Expression [25]
Ras-related protein Rab-8A (RAB8A) OTPB54Y3 RAB8A_HUMAN Decreases Expression [30]
C-X-C chemokine receptor type 4 (CXCR4) OTUFSBX2 CXCR4_HUMAN Affects Expression [25]
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PPP2CB) OT24GMCM PP2AB_HUMAN Increases Expression [30]
Small ribosomal subunit protein eS26 (RPS26) OTBYTA6A RS26_HUMAN Affects Expression [25]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (GNB2) OT3JPRCQ GBB2_HUMAN Decreases Expression [30]
Actin, gamma-enteric smooth muscle (ACTG2) OTRDWUO0 ACTH_HUMAN Decreases Expression [30]
Hemoglobin subunit beta (HBB) OT514IKQ HBB_HUMAN Affects Splicing [84]
E3 ubiquitin-protein ligase RNF4 (RNF4) OTCMXQRE RNF4_HUMAN Decreases Expression [30]
Cyclin-A1 (CCNA1) OTX4HD45 CCNA1_HUMAN Affects Expression [109]
Interferon-induced 35 kDa protein (IFI35) OTV9RZ53 IN35_HUMAN Increases Expression [34]
Transcriptional activator protein Pur-alpha (PURA) OT975ELW PURA_HUMAN Affects Expression [25]
Interferon regulatory factor 9 (IRF9) OTK4MYQJ IRF9_HUMAN Increases Expression [34]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Increases Expression [105]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Decreases Expression [24]
Exosome complex component 10 (EXOSC10) OTH8Z0AL EXOSX_HUMAN Increases Metabolism [111]
Transgelin (TAGLN) OTAEZ0KP TAGL_HUMAN Decreases Expression [26]
Myocyte-specific enhancer factor 2B (MEF2B) OT880SE6 MEF2B_HUMAN Affects Expression [25]
A-kinase anchor protein 12 (AKAP12) OTCVRDDX AKA12_HUMAN Affects Expression [25]
Lamin-B2 (LMNB2) OTXRDUOS LMNB2_HUMAN Decreases Expression [24]
Antigen peptide transporter 2 (TAP2) OTWSYFI7 TAP2_HUMAN Increases Expression [112]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Decreases Expression [113]
Keratin, type I cytoskeletal 17 (KRT17) OT6Y1DPK K1C17_HUMAN Affects Expression [25]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Affects Expression [25]
Protein kinase C zeta type (PRKCZ) OTN2FE42 KPCZ_HUMAN Affects Expression [25]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Increases Expression [114]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [73]
Forkhead box protein M1 (FOXM1) OT5887KR FOXM1_HUMAN Decreases Expression [24]
Neuroblast differentiation-associated protein AHNAK (AHNAK) OT6KH1WG AHNK_HUMAN Decreases Expression [26]
Mesoderm posterior protein 2 (MESP2) OT7H4LYA MESP2_HUMAN Increases Expression [29]
Sterol regulatory element-binding protein 2 (SREBF2) OTBXUNPL SRBP2_HUMAN Decreases Expression [24]
Transcription factor 15 (TCF15) OTA6UCWC TCF15_HUMAN Increases Expression [29]
Heat shock protein 75 kDa, mitochondrial (TRAP1) OTNG0L8J TRAP1_HUMAN Affects Expression [24]
TNF receptor-associated factor 2 (TRAF2) OT1MEZZN TRAF2_HUMAN Decreases Expression [99]
Forkhead box protein C1 (FOXC1) OTOWZGYO FOXC1_HUMAN Affects Expression [25]
Vesicle transport protein SEC20 (BNIP1) OT7USYCY SEC20_HUMAN Increases Expression [32]
Baculoviral IAP repeat-containing protein 1 (NAIP) OTLA925F BIRC1_HUMAN Decreases Expression [34]
RE1-silencing transcription factor (REST) OTLL92LQ REST_HUMAN Affects Expression [25]
FAS-associated death domain protein (FADD) OTV7GFHH FADD_HUMAN Decreases Expression [24]
Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) OTS3FVTY M3K1_HUMAN Affects Expression [24]
28 kDa heat- and acid-stable phosphoprotein (PDAP1) OTJSWMOD HAP28_HUMAN Decreases Expression [30]
Aquaporin-6 (AQP6) OTXS6UYY AQP6_HUMAN Decreases Expression [24]
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) OTC41R1E RIPK1_HUMAN Increases Expression [24]
Neurogenic differentiation factor 1 (NEUROD1) OTZQ7QJ2 NDF1_HUMAN Affects Expression [25]
Protein patched homolog 1 (PTCH1) OTMG07H5 PTC1_HUMAN Decreases Expression [93]
CD166 antigen (ALCAM) OTCO4LP7 CD166_HUMAN Decreases Expression [26]
Spectrin alpha chain, non-erythrocytic 1 (SPTAN1) OT6VY3A3 SPTN1_HUMAN Increases Expression [24]
Low-density lipoprotein receptor-related protein 8 (LRP8) OTZ71YV2 LRP8_HUMAN Decreases Expression [34]
Transcription factor E2F2 (E2F2) OTO75RM7 E2F2_HUMAN Decreases Expression [24]
Fas-activated serine/threonine kinase (FASTK) OTTHFZMP FASTK_HUMAN Decreases Expression [24]
Guanidinoacetate N-methyltransferase (GAMT) OTVC87ES GAMT_HUMAN Increases Expression [26]
Transcription factor HES-1 (HES1) OT8P19W2 HES1_HUMAN Increases Activity [115]
Indian hedgehog protein (IHH) OT1DWGXC IHH_HUMAN Decreases Expression [116]
Transmembrane protein 187 (TMEM187) OTOE4G8T TM187_HUMAN Decreases Expression [24]
Pumilio homolog 1 (PUM1) OTTMWP8L PUM1_HUMAN Affects Expression [25]
Major vault protein (MVP) OTJGHJRB MVP_HUMAN Increases Expression [117]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Decreases Expression [109]
Kinesin-like protein KIF14 (KIF14) OTXHT4JM KIF14_HUMAN Decreases Expression [24]
Angiopoietin-1 (ANGPT1) OTVZ1NG3 ANGP1_HUMAN Increases Expression [71]
Sonic hedgehog protein (SHH) OTOG2BXF SHH_HUMAN Decreases Expression [93]
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD) OTBOSJHO TRADD_HUMAN Affects Expression [24]
Heat shock protein beta-2 (HSPB2) OTS01646 HSPB2_HUMAN Increases Phosphorylation [92]
Transcription factor E2F4 (E2F4) OTB3JFH4 E2F4_HUMAN Decreases Expression [24]
BDNF/NT-3 growth factors receptor (NTRK2) OTD557PU NTRK2_HUMAN Decreases Expression [26]
Survival motor neuron protein (SMN2) OT54RLO1 SMN_HUMAN Decreases Expression [34]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Decreases Expression [118]
Kinesin-like protein KIF26B (KIF26B) OTVHWIKR KI26B_HUMAN Decreases Expression [24]
Protein BEAN1 (BEAN1) OT0WLH27 BEAN1_HUMAN Increases Expression [26]
Filamin A-interacting protein 1-like (FILIP1L) OTPY8IMS FIL1L_HUMAN Increases Expression [26]
Borealin (CDCA8) OT17D55D BOREA_HUMAN Decreases Expression [75]
Early estrogen-induced gene 1 protein (EEIG1) OT2BMEAE EEIG1_HUMAN Affects Expression [25]
Transcription initiation factor TFIID subunit 3 (TAF3) OTVMULE9 TAF3_HUMAN Affects Expression [25]
GRAM domain-containing protein 4 (GRAMD4) OT1HXEPM GRAM4_HUMAN Increases Expression [119]
Heme transporter HRG1 (SLC48A1) OTPFHZLO HRG1_HUMAN Affects Expression [25]
Proline/serine-rich coiled-coil protein 1 (PSRC1) OT7MDJMN PSRC1_HUMAN Decreases Expression [75]
Protein aurora borealis (BORA) OTV2ZPKP BORA_HUMAN Decreases Expression [75]
Teashirt homolog 1 (TSHZ1) OTYQ9ECW TSH1_HUMAN Increases Expression [25]
Protein MCM10 homolog (MCM10) OTV0O3JN MCM10_HUMAN Affects Expression [25]
Oligodendrocyte transcription factor 3 (OLIG3) OTU8XLAF OLIG3_HUMAN Decreases Expression [29]
Protein lifeguard 1 (GRINA) OTMC1O66 LFG1_HUMAN Affects Expression [25]
Cyclin-J-like protein (CCNJL) OTU0SRTC CCNJL_HUMAN Affects Expression [25]
Mitofusin-1 (MFN1) OTCBXQZF MFN1_HUMAN Increases Expression [78]
Protein NOXP20 (FAM114A1) OT0208Y4 NXP20_HUMAN Affects Expression [25]
Extracellular serine/threonine protein kinase FAM20C (FAM20C) OTW5YZ7X FA20C_HUMAN Affects Expression [25]
Serine/arginine repetitive matrix protein 1 (SRRM1) OTAY2IP6 SRRM1_HUMAN Decreases Expression [30]
Ankyrin repeat domain-containing protein 36B (ANKRD36B) OT3MW415 AN36B_HUMAN Affects Expression [25]
Metallothionein-1M (MT1M) OTVT8PLU MT1M_HUMAN Increases Expression [26]
Integral membrane protein GPR137C (GPR137C) OTMEB9QG G137C_HUMAN Affects Expression [25]
Fibrinogen C domain-containing protein 1 (FIBCD1) OTSVT07B FBCD1_HUMAN Decreases Expression [24]
tRNA-uridine aminocarboxypropyltransferase 1 (DTWD1) OT95QT6P DTWD1_HUMAN Increases Expression [32]
ER membrane protein complex subunit 1 (EMC1) OTYAH4LX EMC1_HUMAN Affects Expression [25]
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) OTBIN5IP SCPDL_HUMAN Increases Expression [34]
Minor histocompatibility antigen H13 (HM13) OTGEO1LP HM13_HUMAN Affects Expression [25]
Serine/threonine-protein kinase Nek9 (NEK9) OT4VQCL5 NEK9_HUMAN Decreases Expression [30]
Grainyhead-like protein 3 homolog (GRHL3) OT1V4ZEH GRHL3_HUMAN Affects Expression [25]
Transmembrane protein 40 (TMEM40) OTSJKKNA TMM40_HUMAN Affects Expression [25]
Lipase member H (LIPH) OTRGYLKL LIPH_HUMAN Decreases Expression [30]
MAP kinase-activating death domain protein (MADD) OTUFYVGG MADD_HUMAN Affects Expression [24]
E3 ubiquitin-protein ligase MYLIP (MYLIP) OTL0PFGV MYLIP_HUMAN Affects Expression [25]
Serine protease HTRA1 (HTRA1) OTR8ACBF HTRA1_HUMAN Increases Expression [26]
Symplekin (SYMPK) OTYAUDXV SYMPK_HUMAN Decreases Expression [30]
Caspase-10 (CASP10) OTE6J88E CASPA_HUMAN Increases Expression [24]
Kallikrein-6 (KLK6) OTIEA234 KLK6_HUMAN Decreases Expression [26]
Solute carrier organic anion transporter family member 2A1 (SLCO2A1) OT3062CA SO2A1_HUMAN Affects Expression [25]
Major histocompatibility complex class I-related gene protein (MR1) OTZU3XX7 HMR1_HUMAN Increases Expression [34]
Optineurin (OPTN) OT2UXWH9 OPTN_HUMAN Increases Expression [34]
Sororin (CDCA5) OTZLCQ5U CDCA5_HUMAN Increases Expression [30]
THO complex subunit 1 (THOC1) OTVABJ4Z THOC1_HUMAN Decreases Expression [30]
Chronophin (PDXP) OTZ7GN95 PLPP_HUMAN Decreases Expression [30]
Cytochrome c oxidase assembly protein COX14 (COX14) OTQ378WN COX14_HUMAN Affects Expression [24]
Retina and anterior neural fold homeobox protein 2 (RAX2) OT1HD6CF RAX2_HUMAN Affects Expression [25]
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (AGAP3) OT8C6PKL AGAP3_HUMAN Decreases Expression [30]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Increases Expression [120]
Serine/threonine-protein kinase Nek1 (NEK1) OTBUCUW6 NEK1_HUMAN Decreases Expression [30]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Affects Expression [25]
Transcription factor ATOH8 (ATOH8) OT7SY3BN ATOH8_HUMAN Affects Expression [25]
Pre-mRNA-splicing factor 18 (PRPF18) OTX4VZ4R PRP18_HUMAN Decreases Expression [34]
MyoD family inhibitor (MDFI) OTIA6YUG MDFI_HUMAN Decreases Expression [26]
Noelin (OLFM1) OTOYPEWW NOE1_HUMAN Increases Expression [26]
Protein smoothened (SMO) OTXXE208 SMO_HUMAN Decreases Expression [93]
Retinoic acid receptor responder protein 2 (RARRES2) OT1BJE8K RARR2_HUMAN Decreases Expression [30]
NADH dehydrogenase 1 alpha subcomplex assembly factor 3 (NDUFAF3) OT4MCB6W NDUF3_HUMAN Decreases Expression [24]
Multiple myeloma tumor-associated protein 2 (C1ORF35) OTK6PUYF MMTA2_HUMAN Affects Expression [25]
Mitochondrial adenyl nucleotide antiporter SLC25A23 (SLC25A23) OTG0B7RM SCMC3_HUMAN Affects Expression [25]
Histone-lysine N-methyltransferase SETD5 (SETD5) OTRPAVEO SETD5_HUMAN Affects Expression [25]
Hyaluronan and proteoglycan link protein 2 (HAPLN2) OT0G3KEQ HPLN2_HUMAN Affects Expression [25]
PR domain zinc finger protein 14 (PRDM14) OTWZKY4L PRD14_HUMAN Affects Expression [24]
Neurogenin-2 (NEUROG2) OTAEMIGT NGN2_HUMAN Decreases Expression [29]
Kallikrein-15 (KLK15) OT7BVG17 KLK15_HUMAN Affects Expression [25]
Serine/threonine-protein kinase PLK3 (PLK3) OT19CT2Z PLK3_HUMAN Increases Expression [105]
Complex I assembly factor ACAD9, mitochondrial (ACAD9) OT4HITJ6 ACAD9_HUMAN Decreases Expression [24]
2-oxoglutarate and iron-dependent oxygenase JMJD4 (JMJD4) OTYZGH63 JMJD4_HUMAN Decreases Expression [24]
ATP-binding cassette sub-family B member 6 (ABCB6) OTPGZFES ABCB6_HUMAN Decreases Expression [112]
StAR-related lipid transfer protein 7, mitochondrial (STARD7) OTDUZ296 STAR7_HUMAN Affects Expression [25]
Muscleblind-like protein 1 (MBNL1) OTOV7J85 MBNL1_HUMAN Decreases Expression [30]
Mitogen-activated protein kinase kinase kinase 20 (MAP3K20) OT0ALMEG M3K20_HUMAN Affects Expression [25]
NF-kappa-B inhibitor-interacting Ras-like protein 1 (NKIRAS1) OTWETJTL KBRS1_HUMAN Affects Expression [25]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) OT0DZGY4 E2AK3_HUMAN Increases Expression [76]
Myoferlin (MYOF) OTRFC3IJ MYOF_HUMAN Decreases Expression [26]
Programmed cell death 1 ligand 1 (CD274) OTJ0VFDL PD1L1_HUMAN Increases Expression [121]
NADH dehydrogenase 1 alpha subcomplex assembly factor 4 (NDUFAF4) OTWJ5B9M NDUF4_HUMAN Affects Expression [24]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (HMG20B) OTY94WRA HM20B_HUMAN Decreases Expression [30]
MyoD family inhibitor domain-containing protein (MDFIC) OTSRYBWZ MDFIC_HUMAN Affects Expression [25]
Ribosome-binding protein 1 (RRBP1) OT4ZTPTM RRBP1_HUMAN Decreases Expression [26]
Small proline-rich protein 3 (SPRR3) OTN9QJKG SPRR3_HUMAN Affects Expression [25]
Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D) OTOSRDJT TR10D_HUMAN Increases Expression [69]
Dickkopf-related protein 4 (DKK4) OTWCCVF6 DKK4_HUMAN Increases Expression [25]
DNA repair protein REV1 (REV1) OTHIKICX REV1_HUMAN Affects Expression [25]
Hydroxyproline dehydrogenase (PRODH2) OTHO2TO0 HYPDH_HUMAN Decreases Expression [26]
FK506-binding protein-like (FKBPL) OTR9ND6K FKBPL_HUMAN Increases Expression [106]
Suppressor of fused homolog (SUFU) OT0IRYG1 SUFU_HUMAN Decreases Expression [93]
Probable G-protein coupled receptor 132 (GPR132) OTJ5WHHX GP132_HUMAN Increases Expression [25]
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) OTNONPMB GLCNE_HUMAN Decreases Expression [26]
C-type lectin domain family 11 member A (CLEC11A) OT9KBH7C CLC11_HUMAN Decreases Expression [26]
DNA replication complex GINS protein PSF2 (GINS2) OT974IYI PSF2_HUMAN Affects Expression [25]
R3H domain-containing protein 2 (R3HDM2) OTMJ3S6J R3HD2_HUMAN Affects Expression [25]
Complex I intermediate-associated protein 30, mitochondrial (NDUFAF1) OTYK9JU6 CIA30_HUMAN Increases Expression [24]
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (SAMHD1) OTBCIBC7 SAMH1_HUMAN Affects Expression [25]
Angiopoietin-related protein 3 (ANGPTL3) OTCD5Z9W ANGL3_HUMAN Decreases Expression [76]
Origin recognition complex subunit 6 (ORC6) OTKQN3KP ORC6_HUMAN Increases Expression [25]
NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) OTO3WI7S NDUB9_HUMAN Affects Expression [24]
Soluble TNF receptor II (CRMB1) OT06I7G2 CRMB_CAMPM Increases ADR [122]
Mitochondrial pyruvate carrier 2 (MPC2) OT0GHXGG MPC2_HUMAN Affects Response To Substance [37]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Decreases Response To Substance [123]
Tumor protein p73 (TP73) OT0LUO47 P73_HUMAN Affects Response To Substance [124]
Nucleoside diphosphate kinase A (NME1) OT0NELQ1 NDKA_HUMAN Affects Response To Substance [38]
Four and a half LIM domains protein 2 (FHL2) OT0OAYWT FHL2_HUMAN Affects Response To Substance [37]
Tripartite motif-containing protein 2 (TRIM2) OT0V1YVC TRIM2_HUMAN Affects Response To Substance [37]
Neuropilin and tolloid-like protein 2 (NETO2) OT0YAMC0 NETO2_HUMAN Affects Response To Substance [37]
Sperm protein associated with the nucleus on the X chromosome C (SPANXC) OT1033B9 SPNXC_HUMAN Affects Response To Substance [37]
Acid ceramidase (ASAH1) OT1DNGXL ASAH1_HUMAN Affects Response To Substance [37]
Solute carrier family 35 member F5 (SLC35F5) OT1FX2QO S35F5_HUMAN Affects Response To Substance [125]
Replication factor C subunit 3 (RFC3) OT1MS7AO RFC3_HUMAN Affects Response To Substance [38]
Amyloid beta precursor protein binding family B member 2 (APBB2) OT1VD51B APBB2_HUMAN Affects Response To Substance [37]
Carboxypeptidase D (CPD) OT2CS64Y CBPD_HUMAN Affects Response To Substance [37]
Uncharacterized protein C11orf24 (C11ORF24) OT2DOJ6E CK024_HUMAN Affects Response To Substance [37]
La-related protein 4B (LARP4B) OT2HI0QE LAR4B_HUMAN Affects Response To Substance [37]
Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3) OT2HZK5M GTR3_HUMAN Affects Response To Substance [37]
Nucleoside diphosphate kinase, mitochondrial (NME4) OT2JTT42 NDKM_HUMAN Affects Response To Substance [37]
Chromobox protein homolog 1 (CBX1) OT2L4XZX CBX1_HUMAN Affects Response To Substance [37]
Kelch-like protein 7 (KLHL7) OT2OF1O8 KLHL7_HUMAN Affects Response To Substance [37]
LIM and SH3 domain protein 1 (LASP1) OT2QIDCL LASP1_HUMAN Affects Response To Substance [37]
Protein transport protein Sec31A (SEC31A) OT2U42AC SC31A_HUMAN Affects Response To Substance [37]
Protein-tyrosine sulfotransferase 2 (TPST2) OT2XKFCE TPST2_HUMAN Affects Response To Substance [37]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Decreases Response To Substance [126]
Protein FAM171A1 (FAM171A1) OT33BHEP F1711_HUMAN Affects Response To Substance [37]
Very long chain fatty acid elongase 5 (ELOVL5) OT375W1Z ELOV5_HUMAN Affects Response To Substance [37]
Ubiquitin carboxyl-terminal hydrolase CYLD (CYLD) OT37FKH0 CYLD_HUMAN Increases Response To Substance [127]
Angiogenin (ANG) OT3ECS6P ANGI_HUMAN Affects Response To Substance [37]
Focal adhesion kinase 1 (PTK2) OT3Q1JDY FAK1_HUMAN Decreases Response To Substance [128]
Hypermethylated in cancer 2 protein (HIC2) OT3VP1D9 HIC2_HUMAN Affects Response To Substance [37]
Sorcin (SRI) OT4R3EAC SORCN_HUMAN Decreases Response To Substance [129]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) OT4SO7J4 BNIP3_HUMAN Affects Response To Substance [130]
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (OXCT1) OT536PE7 SCOT1_HUMAN Affects Response To Substance [37]
DNA repair nuclease/redox regulator APEX1 (APEX1) OT53OI14 APEX1_HUMAN Increases Response To Substance [131]
Breast carcinoma-amplified sequence 4 (BCAS4) OT596N5E BCAS4_HUMAN Affects Response To Substance [37]
Myosin phosphatase Rho-interacting protein (MPRIP) OT5FV5NS MPRIP_HUMAN Affects Response To Substance [37]
Collagen alpha-2(V) chain (COL5A2) OT5VOSQE CO5A2_HUMAN Affects Response To Substance [37]
Tumor necrosis factor receptor superfamily member 5 (CD40) OT5YU2XB TNR5_HUMAN Decreases Response To Substance [132]
Mitochondrial enolase superfamily member 1 (ENOSF1) OT65D3ZK ENOF1_HUMAN Decreases Response To Substance [133]
Macrophage colony-stimulating factor 1 (CSF1) OT68M7RD CSF1_HUMAN Affects Response To Substance [37]
Myosin regulatory light polypeptide 9 (MYL9) OT6B22JB MYL9_HUMAN Affects Response To Substance [37]
Glutamate--cysteine ligase regulatory subunit (GCLM) OT6CP234 GSH0_HUMAN Affects Response To Substance [37]
Melanoma-associated antigen D1 (MAGED1) OT6EOLFC MAGD1_HUMAN Affects Response To Substance [38]
DNA replication licensing factor MCM7 (MCM7) OT6FXC6K MCM7_HUMAN Affects Response To Substance [38]
Electron transfer flavoprotein subunit beta (ETFB) OT6Q6FBD ETFB_HUMAN Affects Response To Substance [38]
Opioid growth factor receptor-like protein 1 (OGFRL1) OT6QGBYE OGRL1_HUMAN Affects Response To Substance [37]
DNA topoisomerase 2-binding protein 1 (TOPBP1) OT6UPZPD TOPB1_HUMAN Affects Response To Substance [38]
Transforming protein RhoA (RHOA) OT6YOJ9N RHOA_HUMAN Decreases Response To Substance [134]
GTP-binding protein 4 (GTPBP4) OT6ZHAWC GTPB4_HUMAN Affects Response To Substance [37]
Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) OT714BUO AL3A2_HUMAN Affects Response To Substance [37]
Cytosolic acyl coenzyme A thioester hydrolase (ACOT7) OT7C68YV BACH_HUMAN Affects Response To Substance [38]
Polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3) OT7M67WT GALT3_HUMAN Affects Response To Substance [37]
Pro-adrenomedullin (ADM) OT7T0TA4 ADML_HUMAN Affects Response To Substance [37]
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) OT7Y43A1 PP1A_HUMAN Affects Response To Substance [37]
CDKN2A-interacting protein (CDKN2AIP) OT80RRQJ CARF_HUMAN Affects Response To Substance [37]
Cbp/p300-interacting transactivator 2 (CITED2) OT812TV7 CITE2_HUMAN Affects Response To Substance [38]
Peptidyl-prolyl cis-trans isomerase FKBP1B (FKBP1B) OT8CMPB2 FKB1B_HUMAN Affects Response To Substance [37]
Mortality factor 4-like protein 2 (MORF4L2) OT8OI3EC MO4L2_HUMAN Decreases Response To Substance [135]
Putative hydrolase DDAH2 (DDAH2) OT8Q40G2 DDAH2_HUMAN Affects Response To Substance [37]
Pre-B-cell leukemia transcription factor 3 (PBX3) OT8WMVM4 PBX3_HUMAN Affects Response To Substance [37]
Intersectin-1 (ITSN1) OT8YF3S5 ITSN1_HUMAN Affects Response To Substance [37]
Frizzled-2 (FZD2) OT952ML1 FZD2_HUMAN Affects Response To Substance [37]
Galectin-3-binding protein (LGALS3BP) OT9AGQKH LG3BP_HUMAN Affects Response To Substance [37]
L-lactate dehydrogenase B chain (LDHB) OT9B1CT3 LDHB_HUMAN Affects Response To Substance [37]
Transcription factor MafF (MAFF) OT9B7MX0 MAFF_HUMAN Affects Response To Substance [37]
Epsilon-sarcoglycan (SGCE) OT9F17JB SGCE_HUMAN Affects Response To Substance [37]
Carbohydrate sulfotransferase 7 (CHST7) OT9HCUST CHST7_HUMAN Affects Response To Substance [37]
Adapter molecule crk (CRK) OT9Q5YSN CRK_HUMAN Affects Response To Substance [37]
Dysbindin domain-containing protein 2 (DBNDD2) OT9RI580 DBND2_HUMAN Affects Response To Substance [37]
Lanosterol synthase (LSS) OT9W2SFH LSS_HUMAN Affects Response To Substance [37]
Perilipin-3 (PLIN3) OT9ZA7MR PLIN3_HUMAN Affects Response To Substance [37]
Tissue factor pathway inhibitor (TFPI) OTA0FX16 TFPI1_HUMAN Affects Response To Substance [37]
Apolipoprotein C-I (APOC1) OTA58CED APOC1_HUMAN Affects Response To Substance [37]
Ribonuclease 4 (RNASE4) OTA5SZLC RNAS4_HUMAN Affects Response To Substance [37]
SEC14-like protein 1 (SEC14L1) OTA75FET S14L1_HUMAN Affects Response To Substance [37]
DNA polymerase epsilon subunit 2 (POLE2) OTAC9V6L DPOE2_HUMAN Affects Response To Substance [37]
Integrin alpha-V (ITGAV) OTAM7JTR ITAV_HUMAN Affects Response To Substance [37]
Receptor-type tyrosine-protein phosphatase kappa (PTPRK) OTAP5AT3 PTPRK_HUMAN Affects Response To Substance [37]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Decreases Response To Substance [136]
Collagen alpha-3(VI) chain (COL6A3) OTAS6R6I CO6A3_HUMAN Affects Response To Substance [37]
Cyclin-dependent kinase inhibitor 1C (CDKN1C) OTASTJ3Q CDN1C_HUMAN Affects Response To Substance [130]
Lanosterol 14-alpha demethylase (CYP51A1) OTAYHG9C CP51A_HUMAN Affects Response To Substance [37]
Sterol O-acyltransferase 1 (SOAT1) OTB4Y5RJ SOAT1_HUMAN Affects Response To Substance [37]
Ras-related protein R-Ras (RRAS) OTBBF28C RRAS_HUMAN Affects Response To Substance [37]
G1/S-specific cyclin-E2 (CCNE2) OTBBUKQQ CCNE2_HUMAN Affects Response To Substance [130]
Cochlin (COCH) OTBEHD89 COCH_HUMAN Affects Response To Substance [37]
Solute carrier family 2, facilitated glucose transporter member 14 (SLC2A14) OTBFIOVY GTR14_HUMAN Affects Response To Substance [37]
Protein transport protein Sec23A (SEC23A) OTBRNIJ3 SC23A_HUMAN Affects Response To Substance [37]
Alpha-galactosidase A (GLA) OTBSR6DT AGAL_HUMAN Affects Response To Substance [37]
Regenerating islet-derived protein 4 (REG4) OTBWIKOA REG4_HUMAN Decreases Response To Substance [137]
Transmembrane protein 184B (TMEM184B) OTBZY7E9 T184B_HUMAN Affects Response To Substance [37]
Transforming growth factor beta-2 proprotein (TGFB2) OTC0TXEP TGFB2_HUMAN Affects Response To Substance [37]
Adenylyl cyclase-associated protein 2 (CAP2) OTC1WFNO CAP2_HUMAN Affects Response To Substance [37]
RNA-binding protein 5 (RBM5) OTCBWHHV RBM5_HUMAN Affects Response To Substance [38]
Neuropilin-1 (NRP1) OTCGULYV NRP1_HUMAN Decreases Response To Substance [138]
Baculoviral IAP repeat-containing protein 6 (BIRC6) OTCQJAB0 BIRC6_HUMAN Decreases Response To Substance [139]
Probable cytosolic iron-sulfur protein assembly protein CIAO1 (CIAO1) OTCU8PFI CIAO1_HUMAN Affects Response To Substance [38]
Aldehyde dehydrogenase 1A1 (ALDH1A1) OTCUWZKB AL1A1_HUMAN Affects Response To Substance [37]
Adhesion G protein-coupled receptor L2 (ADGRL2) OTCXD2YR AGRL2_HUMAN Affects Response To Substance [37]
Large ribosomal subunit protein eL24 (RPL24) OTCY9DEB RL24_HUMAN Affects Response To Substance [38]
Tropomyosin alpha-1 chain (TPM1) OTD73X6R TPM1_HUMAN Affects Response To Substance [37]
Protein timeless homolog (TIMELESS) OTD8DCBJ TIM_HUMAN Affects Response To Substance [38]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Increases Response To Substance [135]
Gamma-adducin (ADD3) OTDRSHAZ ADDG_HUMAN Affects Response To Substance [37]
Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) OTDS2EAR TNR1B_HUMAN Affects Response To Substance [125]
DNA polymerase subunit gamma-1 (POLG) OTDUCT04 DPOG1_HUMAN Affects Response To Substance [38]
EGF-like repeat and discoidin I-like domain-containing protein 3 (EDIL3) OTDVVNS0 EDIL3_HUMAN Affects Response To Substance [37]
Cytosolic phospholipase A2 (PLA2G4A) OTE70SOT PA24A_HUMAN Affects Response To Substance [37]
Alternative prion protein (PRNP) OTE85L1Q APRIO_HUMAN Decreases Response To Substance [140]
Very-long-chain (HACD1) OTEC7EP7 HACD1_HUMAN Affects Response To Substance [37]
DNA ligase 1 (LIG1) OTEEQS43 DNLI1_HUMAN Affects Response To Substance [38]
H(+)/Cl(-) exchange transporter 3 (CLCN3) OTEEXNMU CLCN3_HUMAN Affects Response To Substance [37]
Maternal embryonic leucine zipper kinase (MELK) OTEY2UQA MELK_HUMAN Affects Response To Substance [38]
Proteolipid protein 2 (PLP2) OTEZ4LOV PLP2_HUMAN Affects Response To Substance [37]
Paraneoplastic antigen Ma2 (PNMA2) OTF5YBQG PNMA2_HUMAN Affects Response To Substance [37]
Mitogen-activated protein kinase 7 (MAPK7) OTF7H7L7 MK07_HUMAN Decreases Response To Substance [141]
Kelch-like ECH-associated protein 1 (KEAP1) OTFHOD0C KEAP1_HUMAN Affects Response To Substance [142]
Annexin A2 (ANXA2) OTFNS0CC ANXA2_HUMAN Decreases Response To Substance [63]
E3 ubiquitin-protein ligase NEDD4 (NEDD4) OTFPXLXT NEDD4_HUMAN Affects Response To Substance [37]
SOSS complex subunit B2 (NABP1) OTFTNFHW SOSB2_HUMAN Increases ADR [143]
Centromere protein X (CENPX) OTG1RAKJ CENPX_HUMAN Affects Response To Substance [37]
Protein AF1q (MLLT11) OTG5RVHC AF1Q_HUMAN Affects Response To Substance [37]
DNA mismatch repair protein Mlh1 (MLH1) OTG5XDD8 MLH1_HUMAN Increases Response To Substance [144]
Lymphocyte antigen 6 complex locus protein G6d (LY6G6D) OTG75QOC LY66D_HUMAN Affects Response To Substance [37]
Regulator of G-protein signaling 4 (RGS4) OTG94HHL RGS4_HUMAN Affects Response To Substance [37]
TRIO and F-actin-binding protein (TRIOBP) OTGB5WHC TARA_HUMAN Affects Response To Substance [37]
Tubulin-specific chaperone E (TBCE) OTGBSTKS TBCE_HUMAN Affects Response To Substance [37]
Leucine-rich repeat transmembrane protein FLRT2 (FLRT2) OTGD8TID FLRT2_HUMAN Affects Response To Substance [37]
DNA replication licensing factor MCM2 (MCM2) OTGGORIQ MCM2_HUMAN Affects Response To Substance [38]
Fibroblast growth factor 7 (FGF7) OTGK6ANL FGF7_HUMAN Decreases Response To Substance [145]
Isopentenyl-diphosphate Delta-isomerase 1 (IDI1) OTGM06VJ IDI1_HUMAN Affects Response To Substance [37]
Melanoma-associated antigen 4 (MAGEA4) OTGP9SD0 MAGA4_HUMAN Affects Response To Substance [37]
Phospholipid scramblase 1 (PLSCR1) OTGY9B5T PLS1_HUMAN Affects Response To Substance [37]
Partitioning defective 3 homolog (PARD3) OTH5BPLO PARD3_HUMAN Affects Response To Substance [37]
Flavin reductase (BLVRB) OTHCFN2C BLVRB_HUMAN Affects Response To Substance [37]
Heat shock protein beta-1 (HSPB1) OTHFZ8ED HSPB1_HUMAN Decreases Response To Substance [146]
Potassium voltage-gated channel subfamily A member 5 (KCNA5) OTHI2N71 KCNA5_HUMAN Increases Response To Substance [147]
Translationally-controlled tumor protein (TPT1) OTHMTRJU TCTP_HUMAN Decreases Response To Substance [126]
Forkhead box protein O3 (FOXO3) OTHXQG4P FOXO3_HUMAN Affects Response To Substance [130]
Dystonin (DST) OTHZBM4X DYST_HUMAN Affects Response To Substance [37]
FYVE, RhoGEF and PH domain-containing protein 6 (FGD6) OTI0T62C FGD6_HUMAN Affects Response To Substance [37]
Protein S100-A11 (S100A11) OTI57KDN S10AB_HUMAN Increases Response To Substance [148]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) OTI862QH CPT1A_HUMAN Affects Response To Substance [38]
Laminin subunit gamma-1 (LAMC1) OTIG527N LAMC1_HUMAN Affects Response To Substance [37]
Baculoviral IAP repeat-containing protein 7 (BIRC7) OTITCGHB BIRC7_HUMAN Decreases Response To Substance [149]
Kinesin-like protein KIF2C (KIF2C) OTJ8G3NP KIF2C_HUMAN Affects Response To Substance [38]
Replication factor C subunit 2 (RFC2) OTJ9N6BD RFC2_HUMAN Affects Response To Substance [38]
Retrotransposon Gag-like protein 8C (RTL8C) OTJA37NU RTL8C_HUMAN Affects Response To Substance [37]
Cyclin-F (CCNF) OTJFVU43 CCNF_HUMAN Affects Response To Substance [130]
Heat shock cognate 71 kDa protein (HSPA8) OTJI2RCI HSP7C_HUMAN Affects Response To Substance [37]
Rhomboid-related protein 2 (RHBDL2) OTJPJ8N6 RHBL2_HUMAN Affects Response To Substance [37]
Unconventional myosin-VI (MYO6) OTJQYRC7 MYO6_HUMAN Affects Response To Substance [37]
Endothelin-1 receptor (EDNRA) OTK9T5O3 EDNRA_HUMAN Affects Response To Substance [150]
Serine/threonine-protein kinase 38 (STK38) OTKMYCYR STK38_HUMAN Affects Response To Substance [37]
Starch-binding domain-containing protein 1 (STBD1) OTKPS9AM STBD1_HUMAN Affects Response To Substance [37]
Enoyl-CoA hydratase domain-containing protein 3, mitochondrial (ECHDC3) OTKU2RMC ECHD3_HUMAN Affects Response To Substance [37]
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (MGAT2) OTKXMSM7 MGAT2_HUMAN Affects Response To Substance [37]
Calcium-binding tyrosine phosphorylation-regulated protein (CABYR) OTKYMT99 CABYR_HUMAN Affects Response To Substance [37]
EF-hand domain-containing protein D1 (EFHD1) OTL5INE4 EFHD1_HUMAN Affects Response To Substance [37]
Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B) OTL9I7LO GA45B_HUMAN Decreases Response To Substance [151]
Sorting nexin-6 (SNX6) OTLKQYJU SNX6_HUMAN Affects Response To Substance [37]
PDZ and LIM domain protein 5 (PDLIM5) OTLQVV22 PDLI5_HUMAN Affects Response To Substance [37]
Tyrosine-protein kinase Fyn (FYN) OTLSLVZS FYN_HUMAN Affects Response To Substance [37]
Separin (ESPL1) OTMGEVOK ESPL1_HUMAN Affects Response To Substance [38]
Sperm protein associated with the nucleus on the X chromosome A (SPANXA1) OTMK3QIS SPNXA_HUMAN Affects Response To Substance [37]
Pleckstrin homology domain-containing family O member 1 (PLEKHO1) OTMVUQ9W PKHO1_HUMAN Affects Response To Substance [37]
Ubiquitin-conjugating enzyme E2 R1 (CDC34) OTNBK390 UB2R1_HUMAN Affects Response To Substance [37]
Protein ENTREP3 (ENTREP3) OTNJB3FP EREP3_HUMAN Affects Response To Substance [37]
HMG box transcription factor BBX (BBX) OTNQ3QUC BBX_HUMAN Affects Response To Substance [37]
Melanoma-associated antigen D4 (MAGED4B) OTO37U7W MAGD4_HUMAN Affects Response To Substance [37]
Purine nucleoside phosphorylase (PNP) OTO5NIJ2 PNPH_HUMAN Affects Response To Substance [38]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Decreases Response To Substance [152]
Galactoside alpha-(1,2)-fucosyltransferase 1 (FUT1) OTODG57A FUT1_HUMAN Affects Response To Substance [153]
Succinate dehydrogenase flavoprotein subunit, mitochondrial (SDHA) OTOJ8QFF SDHA_HUMAN Affects Response To Substance [38]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Decreases Response To Substance [154]
Copper homeostasis protein cutC homolog (CUTC) OTOVHLU9 CUTC_HUMAN Affects Response To Substance [37]
Phosphatidylserine decarboxylase proenzyme, mitochondrial (PISD) OTP9COQT PISD_HUMAN Affects Response To Substance [38]
Ras-related protein Rab-20 (RAB20) OTP9OOVS RAB20_HUMAN Affects Response To Substance [37]
MHC class I polypeptide-related sequence A (MICA) OTPEIEAR MICA_HUMAN Affects Response To Substance [37]
Tensin-3 (TNS3) OTPG2D8Z TENS3_HUMAN Affects Response To Substance [37]
Neurotensin/neuromedin N (NTS) OTPGDNQS NEUT_HUMAN Affects Response To Substance [37]
Na(+)/citrate cotransporter (SLC13A5) OTPH1TA7 S13A5_HUMAN Decreases Response To Substance [155]
Interferon alpha-1/13 (IFNA1) OTPMKY0L IFNA1_HUMAN Increases Abundance [10]
SPARC (SPARC) OTPN90H0 SPRC_HUMAN Increases Response To Substance [156]
M-phase inducer phosphatase 3 (CDC25C) OTPQI71S MPIP3_HUMAN Affects Response To Substance [38]
Protein C-mannosyl-transferase DPY19L1 (DPY19L1) OTPULBDX D19L1_HUMAN Affects Response To Substance [37]
Transcription factor SOX-18 (SOX18) OTPUMHWA SOX18_HUMAN Affects Response To Substance [37]
Copper-transporting ATPase 2 (ATP7B) OTPWLNCO ATP7B_HUMAN Increases Response To Substance [135]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Affects Response To Substance [37]
Centromere protein U (CENPU) OTQ4TZRS CENPU_HUMAN Affects Response To Substance [38]
Adhesion G-protein coupled receptor G1 (ADGRG1) OTQBB8NT AGRG1_HUMAN Affects Response To Substance [37]
Angiopoietin-related protein 4 (ANGPTL4) OTQL5SPX ANGL4_HUMAN Affects Response To Substance [37]
Serine-protein kinase ATM (ATM) OTQVOHLT ATM_HUMAN Decreases Response To Substance [157]
E3 ubiquitin-protein ligase RNF34 (RNF34) OTQY58LU RNF34_HUMAN Decreases Response To Substance [158]
Transforming growth factor-beta-induced protein ig-h3 (TGFBI) OTR443C5 BGH3_HUMAN Affects Response To Substance [37]
Kelch-like protein 9 (KLHL9) OTRGEG3Z KLHL9_HUMAN Affects Response To Substance [37]
LIM domain kinase 2 (LIMK2) OTRJD7VZ LIMK2_HUMAN Affects Response To Substance [37]
Large ribosomal subunit protein eL6 (RPL6) OTRU71O4 RL6_HUMAN Decreases Response To Substance [159]
Perilipin-2 (PLIN2) OTRXJ9UN PLIN2_HUMAN Affects Response To Substance [37]
MHC class I polypeptide-related sequence B (MICB) OTS2DVDW MICB_HUMAN Affects Response To Substance [37]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) OTSBQR6D PLCG1_HUMAN Decreases Response To Substance [160]
Thymosin beta-15A (TMSB15A) OTSBWCES TB15A_HUMAN Affects Response To Substance [130]
Protein phosphatase 1 regulatory subunit 1B (PPP1R1B) OTSIJMQ9 PPR1B_HUMAN Increases Response To Substance [161]
Formin-binding protein 1 (FNBP1) OTSJ5KKA FNBP1_HUMAN Affects Response To Substance [37]
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) OTSMGKXQ EBP_HUMAN Affects Response To Substance [38]
Interleukin-27 receptor subunit alpha (IL27RA) OTSQBAKI I27RA_HUMAN Affects Response To Substance [37]
Rhotekin (RTKN) OTSS8XR6 RTKN_HUMAN Decreases Response To Substance [162]
Procollagen C-endopeptidase enhancer 2 (PCOLCE2) OTSUEQZ1 PCOC2_HUMAN Affects Response To Substance [37]
Collagen alpha-1(III) chain (COL3A1) OTT1EMLM CO3A1_HUMAN Affects Response To Substance [37]
Cdc42 effector protein 1 (CDC42EP1) OTT525WA BORG5_HUMAN Affects Response To Substance [37]
Gap junction alpha-1 protein (GJA1) OTT94MKL CXA1_HUMAN Affects Response To Substance [37]
Nucleophosmin (NPM1) OTTBYYT0 NPM_HUMAN Decreases Response To Substance [163]
Selenide, water dikinase 2 (SEPHS2) OTTFXROR SPS2_HUMAN Affects Response To Substance [37]
DNA polymerase alpha subunit B (POLA2) OTTWQ73N DPOA2_HUMAN Affects Response To Substance [38]
EH domain-containing protein 2 (EHD2) OTTX391J EHD2_HUMAN Affects Response To Substance [37]
Protein enabled homolog (ENAH) OTU49OK5 ENAH_HUMAN Affects Response To Substance [37]
Creatine kinase B-type (CKB) OTUCKOTT KCRB_HUMAN Affects Response To Substance [37]
Phytanoyl-CoA dioxygenase, peroxisomal (PHYH) OTUG4BWA PAHX_HUMAN Affects Response To Substance [37]
Leupaxin (LPXN) OTUNV3CK LPXN_HUMAN Affects Response To Substance [38]
AT-rich interactive domain-containing protein 5B (ARID5B) OTUQ4CQY ARI5B_HUMAN Affects Response To Substance [37]
Max-interacting protein 1 (MXI1) OTUQ9E0D MXI1_HUMAN Affects Response To Substance [37]
Cysteine and glycine-rich protein 1 (CSRP1) OTUS7RM2 CSRP1_HUMAN Affects Response To Substance [37]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) OTUYHB84 MLP3B_HUMAN Affects Response To Substance [38]
Acyl-CoA (FADS1) OTUYOYHX FADS1_HUMAN Affects Response To Substance [37]
Histone deacetylase 2 (HDAC2) OTUYVFKN HDAC2_HUMAN Increases Response To Substance [157]
Nucleolysin TIAR (TIAL1) OTV2KFZH TIAR_HUMAN Affects Response To Substance [38]
Lymphocyte antigen 6 complex locus protein G6c (LY6G6C) OTV7F59X LY66C_HUMAN Affects Response To Substance [37]
ATP-binding cassette sub-family C member 11 (ABCC11) OTVHL7OR MRP8_HUMAN Decreases Response To Substance [164]
Megakaryocyte and platelet inhibitory receptor G6b (MPIG6B) OTVNKQWA G6B_HUMAN Affects Response To Substance [37]
GTP-binding protein Rit1 (RIT1) OTVNOGOH RIT1_HUMAN Affects Response To Substance [37]
Abasic site processing protein HMCES (HMCES) OTVRDL6U HMCES_HUMAN Affects Response To Substance [38]
BAG family molecular chaperone regulator 3 (BAG3) OTVXYUDQ BAG3_HUMAN Affects Response To Substance [37]
Folylpolyglutamate synthase, mitochondrial (FPGS) OTW3F1ZE FOLC_HUMAN Increases Response To Substance [165]
Fanconi anemia group I protein (FANCI) OTW8E3SC FANCI_HUMAN Affects Response To Substance [38]
Retrotransposon-derived protein PEG10 (PEG10) OTWD2278 PEG10_HUMAN Affects Response To Substance [37]
Periostin (POSTN) OTWP62UA POSTN_HUMAN Decreases Response To Substance [166]
Acyl-coenzyme A thioesterase 13 (ACOT13) OTWRUST1 ACO13_HUMAN Affects Response To Substance [37]
DNA primase small subunit (PRIM1) OTWWP8Y6 PRI1_HUMAN Affects Response To Substance [38]
Amyloid-beta A4 precursor protein-binding family A member 2 (APBA2) OTXD8ID1 APBA2_HUMAN Affects Response To Substance [37]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Affects Response To Substance [37]
Interferon gamma (IFNG) OTXG9JM7 IFNG_HUMAN Increases Abundance [10]
Peptidyl-prolyl cis-trans isomerase FKBP11 (FKBP11) OTY2GC67 FKB11_HUMAN Affects Response To Substance [37]
Adhesion G-protein coupled receptor G6 (ADGRG6) OTY2UBXO AGRG6_HUMAN Affects Response To Substance [37]
Class E basic helix-loop-helix protein 41 (BHLHE41) OTY9GJ1Y BHE41_HUMAN Affects Response To Substance [37]
Serine/threonine-protein kinase TAO3 (TAOK3) OTYBATSH TAOK3_HUMAN Affects Response To Substance [38]
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) OTYEJAGZ GPT_HUMAN Affects Response To Substance [37]
Glia-derived nexin (SERPINE2) OTYF5340 GDN_HUMAN Increases ADR [143]
Chloride intracellular channel protein 1 (CLIC1) OTYLFWNG CLIC1_HUMAN Affects Response To Substance [37]
Interferon beta (IFNB1) OTYQGUB5 IFNB_HUMAN Increases Response To Substance [167]
Galectin-3 (LGALS3) OTYQT0ZI LEG3_HUMAN Decreases Response To Substance [168]
ADP-ribosylation factor 3 (ARF3) OTYYQX85 ARF3_HUMAN Affects Response To Substance [38]
Selenide, water dikinase 1 (SEPHS1) OTZ19I59 SPS1_HUMAN Affects Response To Substance [37]
Glutathione S-transferase A4 (GSTA4) OTZ1USIA GSTA4_HUMAN Affects Response To Substance [37]
Thiosulfate sulfurtransferase (TST) OTZ4F5LK THTR_HUMAN Affects Response To Substance [38]
Erythropoietin (EPO) OTZ90CN4 EPO_HUMAN Increases Response To Substance [169]
Fermitin family homolog 2 (FERMT2) OTZNPWWX FERM2_HUMAN Affects Response To Substance [37]
Pro-neuregulin-1, membrane-bound isoform (NRG1) OTZO6F1X NRG1_HUMAN Affects Response To Substance [37]
Latexin (LXN) OTZQ2M6Y LXN_HUMAN Affects Response To Substance [37]
Multidrug and toxin extrusion protein 1 (SLC47A1) OTZX0U5Q S47A1_HUMAN Affects Response To Substance [37]
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⏷ Show the Full List of 1026 DOT(s)
Indication(s) of Dasatinib
Disease Entry ICD 11 Status REF
Blast phase chronic myelogenous leukemia, BCR-ABL1 positive N.A. Approved [6]
Brain disease 8C70-8E61 Approved [6]
Central nervous system disease 8A04-8D87 Approved [6]
Chronic myelogenous leukaemia 2A20.0 Approved [7]
Chronic myeloid leukaemia 2A20 Approved [8]
Glioblastoma 2A00 Approved [6]
Leukemia N.A. Approved [6]
Lung cancer 2C25.0 Approved [6]
Non-small-cell lung cancer 2C25.Y Approved [6]
Plasma cell myeloma 2A83.1 Approved [6]
Multiple myeloma 2A83 Phase 2 [7]
Middle East Respiratory Syndrome (MERS) 1D64 Investigative [9]
Severe acute respiratory syndrome (SARS) 1D65 Investigative [9]
Dasatinib Interacts with 5 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
LCK tyrosine protein kinase (LCK) TT860QF LCK_HUMAN Inhibitor [173]
Fyn tyrosine protein kinase (FYN) TT2B9KF FYN_HUMAN Inhibitor [173]
Fusion protein Bcr-Abl (Bcr-Abl) TTS7G69 BCR_HUMAN-ABL1_HUMAN Inhibitor [173]
Proto-oncogene c-Src (SRC) TT6PKBN SRC_HUMAN Inhibitor [173]
HUMAN fusion protein Bcr-Abl (Bcr-Abl) TTE63HY BCR_HUMAN/ABL1_HUMAN Inhibitor [9]
------------------------------------------------------------------------------------
Dasatinib Interacts with 4 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [174]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [175]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [176]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [176]
------------------------------------------------------------------------------------
Dasatinib Interacts with 4 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [177]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [177]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [177]
Dimethylaniline oxidase 3 (FMO3) DEP76YL FMO3_HUMAN Metabolism [178]
------------------------------------------------------------------------------------
Dasatinib Interacts with 453 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Tyrosine-protein kinase Fyn (FYN) OTLSLVZS FYN_HUMAN Affects Binding [170]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3) OTB6YLFT ENPP3_HUMAN Decreases Expression [170]
Tyrosine-protein kinase HCK (HCK) OTRL6OSI HCK_HUMAN Decreases Phosphorylation [170]
CD63 antigen (CD63) OT2UGZA9 CD63_HUMAN Decreases Expression [170]
Tyrosine-protein kinase Fgr (FGR) OTCUYU9F FGR_HUMAN Affects Binding [170]
Heat shock cognate 71 kDa protein (HSPA8) OTJI2RCI HSP7C_HUMAN Affects Binding [170]
Aminopeptidase N (ANPEP) OTP3WYFD AMPN_HUMAN Decreases Expression [170]
Tyrosine-protein kinase CSK (CSK) OTP03OD0 CSK_HUMAN Affects Binding [170]
Tyrosine-protein kinase Tec (TEC) OTU6QJAJ TEC_HUMAN Affects Binding [170]
Tyrosine-protein kinase FRK (FRK) OTEKV1SC FRK_HUMAN Affects Binding [170]
Ephrin type-A receptor 5 (EPHA5) OTAM0CVX EPHA5_HUMAN Affects Binding [170]
Ephrin type-B receptor 4 (EPHB4) OTKLPVXJ EPHB4_HUMAN Affects Binding [170]
Sialomucin core protein 24 (CD164) OTZ7FIU8 MUC24_HUMAN Decreases Expression [170]
Amidophosphoribosyltransferase (PPAT) OTXK12ZB PUR1_HUMAN Affects Binding [170]
Mitogen-activated protein kinase 14 (MAPK14) OT5TCO3O MK14_HUMAN Affects Binding [170]
Mitogen-activated protein kinase kinase kinase 20 (MAP3K20) OT0ALMEG M3K20_HUMAN Affects Binding [170]
ATP-dependent RNA helicase DDX39A (DDX39A) OT0Z6E1K DX39A_HUMAN Decreases Expression [171]
Cell division cycle 7-related protein kinase (CDC7) OT5133XY CDC7_HUMAN Decreases Expression [171]
Serine/threonine-protein kinase PLK4 (PLK4) OTV8KZDZ PLK4_HUMAN Decreases Expression [171]
Nuclear envelope integral membrane protein 1 (NEMP1) OTWN3S47 NEMP1_HUMAN Decreases Expression [171]
Kinetochore protein NDC80 homolog (NDC80) OTS7D306 NDC80_HUMAN Decreases Expression [171]
Aurora kinase A (AURKA) OTMX0HYT AURKA_HUMAN Decreases Expression [171]
DNA-directed RNA polymerase III subunit RPC7 (POLR3G) OTU3TGQ9 RPC7_HUMAN Decreases Expression [171]
Fanconi anemia group A protein (FANCA) OTPEFJD4 FANCA_HUMAN Decreases Expression [171]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [171]
Monocarboxylate transporter 7 (SLC16A6) OT7BIIZX MOT7_HUMAN Decreases Expression [171]
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Increases Expression [171]
Protein sprouty homolog 2 (SPRY2) OTH0CRCZ SPY2_HUMAN Decreases Expression [171]
Protein regulator of cytokinesis 1 (PRC1) OTHD0XS0 PRC1_HUMAN Decreases Expression [171]
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1) OT80DZMT BUB1_HUMAN Decreases Expression [171]
EGF-like repeat and discoidin I-like domain-containing protein 3 (EDIL3) OTDVVNS0 EDIL3_HUMAN Increases Expression [171]
NUAK family SNF1-like kinase 1 (NUAK1) OTLLHJJQ NUAK1_HUMAN Increases Expression [171]
Neuropilin-2 (NRP2) OTZL256E NRP2_HUMAN Increases Expression [171]
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) OT8KME51 BUB1B_HUMAN Decreases Expression [171]
Tetraspanin-2 (TSPAN2) OTTDPQF1 TSN2_HUMAN Increases Expression [171]
Leupaxin (LPXN) OTUNV3CK LPXN_HUMAN Decreases Expression [171]
Hyaluronan mediated motility receptor (HMMR) OT4M0JTZ HMMR_HUMAN Decreases Expression [171]
DNA polymerase theta (POLQ) OTBHK0E6 DPOLQ_HUMAN Decreases Expression [171]
Cell division control protein 45 homolog (CDC45) OT6NNLOD CDC45_HUMAN Decreases Expression [171]
Glypican-4 (GPC4) OTUJ14DW GPC4_HUMAN Increases Expression [171]
Serpin B7 (SERPINB7) OTZ95LR2 SPB7_HUMAN Decreases Expression [171]
Transient receptor potential cation channel subfamily A member 1 (TRPA1) OTRDIR5M TRPA1_HUMAN Decreases Expression [171]
Ribonuclease H2 subunit A (RNASEH2A) OT8G3G7K RNH2A_HUMAN Decreases Expression [171]
Short-chain dehydrogenase/reductase 3 (DHRS3) OTSK1DTP DHRS3_HUMAN Increases Expression [171]
Dickkopf-related protein 1 (DKK1) OTRDLUSP DKK1_HUMAN Decreases Expression [171]
Centrosomal protein of 152 kDa (CEP152) OTOKZR9B CE152_HUMAN Decreases Expression [171]
Potassium channel subfamily K member 2 (KCNK2) OTWBT8MG KCNK2_HUMAN Decreases Expression [171]
Chromosome-associated kinesin KIF4A (KIF4A) OT3UWL7D KIF4A_HUMAN Decreases Expression [171]
Structural maintenance of chromosomes protein 2 (SMC2) OT5S0DV4 SMC2_HUMAN Decreases Expression [171]
Phospholipid-transporting ATPase ABCA1 (ABCA1) OT94G6BQ ABCA1_HUMAN Increases Expression [171]
Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) OT9QIHEQ RECK_HUMAN Increases Expression [171]
Securin (PTTG1) OTIMYS4W PTTG1_HUMAN Decreases Expression [171]
Histone-lysine N-methyltransferase NSD2 (NSD2) OTQ6SW4R NSD2_HUMAN Decreases Expression [171]
Aldehyde dehydrogenase 1A1 (ALDH1A1) OTCUWZKB AL1A1_HUMAN Increases Expression [171]
Dihydrofolate reductase (DHFR) OT3DVIGM DYR_HUMAN Decreases Expression [171]
Complement C1r subcomponent (C1R) OTA0ZNIU C1R_HUMAN Increases Expression [171]
Urokinase-type plasminogen activator (PLAU) OTX0QGKK UROK_HUMAN Decreases Expression [171]
Alpha-2-macroglobulin (A2M) OTFTX90K A2MG_HUMAN Increases Expression [171]
Insulin-like growth factor II (IGF2) OTJ4O6MW IGF2_HUMAN Increases Expression [171]
Collagen alpha-1(III) chain (COL3A1) OTT1EMLM CO3A1_HUMAN Increases Expression [171]
Collagen alpha-1(IV) chain (COL4A1) OTL6D1YE CO4A1_HUMAN Increases Expression [171]
Alpha-crystallin B chain (CRYAB) OTY4JGYU CRYAB_HUMAN Increases Expression [171]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Decreases Expression [171]
Thymidine kinase, cytosolic (TK1) OTY5JFM1 KITH_HUMAN Decreases Expression [171]
Aldehyde dehydrogenase, mitochondrial (ALDH2) OTKJ9I3N ALDH2_HUMAN Increases Expression [171]
Plasminogen activator inhibitor 2 (SERPINB2) OT72QLZB PAI2_HUMAN Decreases Expression [171]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Increases Expression [171]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Decreases Expression [171]
Integrin alpha-V (ITGAV) OTAM7JTR ITAV_HUMAN Increases Expression [171]
Epoxide hydrolase 1 (EPHX1) OTBKWQER HYEP_HUMAN Increases Expression [171]
Neurofilament medium polypeptide (NEFM) OT8VCBNF NFM_HUMAN Decreases Expression [171]
Laminin subunit beta-1 (LAMB1) OT6J9LJR LAMB1_HUMAN Increases Expression [171]
Asparagine synthetase (ASNS) OT8R922G ASNS_HUMAN Increases Expression [171]
Matrix Gla protein (MGP) OTZWU3FU MGP_HUMAN Increases Expression [171]
Collagen alpha-2(IV) chain (COL4A2) OTJK1LKN CO4A2_HUMAN Increases Expression [171]
Platelet-derived growth factor receptor beta (PDGFRB) OTYSNK9Q PGFRB_HUMAN Increases Expression [171]
Complement C1s subcomponent (C1S) OTCIZU2A C1S_HUMAN Increases Expression [171]
DNA polymerase alpha catalytic subunit (POLA1) OT1WXFVY DPOLA_HUMAN Decreases Expression [171]
Histone H2A.Z (H2AZ1) OT3KJJNQ H2AZ_HUMAN Decreases Expression [171]
Myb-related protein A (MYBL1) OTBJMC2P MYBA_HUMAN Decreases Expression [171]
Myb-related protein B (MYBL2) OTZ3JX8Q MYBB_HUMAN Decreases Expression [171]
Histone H1.4 (H1-4) OTQ450A3 H14_HUMAN Decreases Expression [171]
Clusterin (CLU) OTQGG0JM CLUS_HUMAN Increases Expression [171]
DNA topoisomerase 2-alpha (TOP2A) OT6LPS08 TOP2A_HUMAN Decreases Expression [171]
Fibroblast growth factor 5 (FGF5) OTQXGHBY FGF5_HUMAN Decreases Expression [171]
Collagen alpha-1(XI) chain (COL11A1) OTB0DRMS COBA1_HUMAN Increases Expression [171]
Elastin (ELN) OTFSO7PG ELN_HUMAN Increases Expression [171]
Aggrecan core protein (ACAN) OTUOCW8K PGCA_HUMAN Increases Expression [171]
Histone H1.5 (H1-5) OTAN7RD9 H15_HUMAN Decreases Expression [171]
Stathmin (STMN1) OTDJ4RV0 STMN1_HUMAN Decreases Expression [171]
Lamin-B1 (LMNB1) OT100T3P LMNB1_HUMAN Decreases Expression [171]
Biglycan (BGN) OT3AV6IF PGS1_HUMAN Increases Expression [171]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1) OT3MPPYX ENPP1_HUMAN Decreases Expression [171]
Liver carboxylesterase 1 (CES1) OT9L0LR8 EST1_HUMAN Increases Expression [171]
Integrin alpha-6 (ITGA6) OT3FA39C ITA6_HUMAN Decreases Expression [171]
Ribonucleoside-diphosphate reductase large subunit (RRM1) OTXGQOR9 RIR1_HUMAN Decreases Expression [171]
Insulin-like growth factor-binding protein 5 (IGFBP5) OTRE5V0C IBP5_HUMAN Increases Expression [171]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Decreases Expression [171]
Pentraxin-related protein PTX3 (PTX3) OTPXHRKU PTX3_HUMAN Decreases Expression [171]
High mobility group protein B2 (HMGB2) OTGEGAOK HMGB2_HUMAN Decreases Expression [171]
Cardiac phospholamban (PLN) OTT3RRJN PPLA_HUMAN Increases Expression [171]
G0/G1 switch protein 2 (G0S2) OT8FL49L G0S2_HUMAN Decreases Expression [171]
Dipeptidyl peptidase 4 (DPP4) OT16MVL9 DPP4_HUMAN Increases Expression [171]
Leiomodin-1 (LMOD1) OTZ2MEMG LMOD1_HUMAN Increases Expression [171]
M-phase inducer phosphatase 1 (CDC25A) OTSLKKCO MPIP1_HUMAN Decreases Expression [171]
M-phase inducer phosphatase 3 (CDC25C) OTPQI71S MPIP3_HUMAN Decreases Expression [171]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2) OTOB6J6R RIR2_HUMAN Decreases Expression [171]
Fibroblast growth factor 9 (FGF9) OT2SKDGM FGF9_HUMAN Increases Expression [171]
Sodium- and chloride-dependent taurine transporter (SLC6A6) OT67U7G3 SC6A6_HUMAN Increases Expression [171]
Cyclin-dependent kinases regulatory subunit 2 (CKS2) OTPTMHIV CKS2_HUMAN Decreases Expression [171]
Histone H2B type 1-B (H2BC3) OT1BLFJO H2B1B_HUMAN Decreases Expression [171]
Dual specificity protein kinase TTK (TTK) OTBY1Z5H TTK_HUMAN Decreases Expression [171]
DNA replication licensing factor MCM7 (MCM7) OT6FXC6K MCM7_HUMAN Decreases Expression [171]
Syndecan-2 (SDC2) OTEEHY1D SDC2_HUMAN Increases Expression [171]
Replication factor C subunit 4 (RFC4) OTWALD2R RFC4_HUMAN Decreases Expression [171]
Replication factor C subunit 2 (RFC2) OTJ9N6BD RFC2_HUMAN Decreases Expression [171]
Thrombospondin-2 (THBS2) OTXET551 TSP2_HUMAN Increases Expression [171]
Myosin-10 (MYH10) OTXN2WXS MYH10_HUMAN Increases Expression [171]
Myosin-11 (MYH11) OTVNVWY3 MYH11_HUMAN Increases Expression [171]
Chitinase-3-like protein 1 (CHI3L1) OT2Z7VJH CH3L1_HUMAN Increases Expression [171]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Decreases Expression [171]
Flap endonuclease 1 (FEN1) OT6QGG7O FEN1_HUMAN Decreases Expression [171]
Nicotinamide N-methyltransferase (NNMT) OTFM38GU NNMT_HUMAN Increases Expression [171]
Pre-B-cell leukemia transcription factor 1 (PBX1) OTORABGO PBX1_HUMAN Increases Expression [171]
Replication factor C subunit 5 (RFC5) OTAD79RT RFC5_HUMAN Decreases Expression [171]
Replication factor C subunit 3 (RFC3) OT1MS7AO RFC3_HUMAN Decreases Expression [171]
5-hydroxytryptamine receptor 2B (HTR2B) OTM1AD9J 5HT2B_HUMAN Increases Expression [171]
Lamina-associated polypeptide 2, isoform alpha (TMPO) OTL68EL4 LAP2A_HUMAN Decreases Expression [171]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Increases Expression [171]
Condensin-2 complex subunit D3 (NCAPD3) OTOZY2UL CNDD3_HUMAN Decreases Expression [171]
Neutral amino acid transporter A (SLC1A4) OTVODHAE SATT_HUMAN Increases Expression [171]
Cell surface glycoprotein MUC18 (MCAM) OTT8XKGE MUC18_HUMAN Increases Expression [171]
DNA mismatch repair protein Msh2 (MSH2) OT10H1AB MSH2_HUMAN Decreases Expression [171]
Proliferation marker protein Ki-67 (MKI67) OTA8N1QI KI67_HUMAN Decreases Expression [171]
Glutathione S-transferase Mu 5 (GSTM5) OTMMBFY8 GSTM5_HUMAN Increases Expression [171]
Histone H3-like centromeric protein A (CENPA) OT0NEJ4X CENPA_HUMAN Decreases Expression [171]
Centromere protein F (CENPF) OT7AG0SW CENPF_HUMAN Decreases Expression [171]
DNA primase small subunit (PRIM1) OTWWP8Y6 PRI1_HUMAN Decreases Expression [171]
DNA primase large subunit (PRIM2) OTGT0KTF PRI2_HUMAN Decreases Expression [171]
Thrombospondin-3 (THBS3) OTDKMUBD TSP3_HUMAN Increases Expression [171]
Regulator of G-protein signaling 4 (RGS4) OTG94HHL RGS4_HUMAN Decreases Expression [171]
Selenoprotein P (SELENOP) OT02B8IR SEPP1_HUMAN Increases Expression [171]
Kinetochore-associated protein 1 (KNTC1) OTI2OOFN KNTC1_HUMAN Decreases Expression [171]
Ras association domain-containing protein 2 (RASSF2) OT2JHDO4 RASF2_HUMAN Increases Expression [171]
DNA replication ATP-dependent helicase/nuclease DNA2 (DNA2) OT4DJFFU DNA2_HUMAN Decreases Expression [171]
Breast cancer type 2 susceptibility protein (BRCA2) OTF1XSV1 BRCA2_HUMAN Decreases Expression [171]
Lumican (LUM) OTSRC874 LUM_HUMAN Increases Expression [171]
Calponin-1 (CNN1) OTVPG39Z CNN1_HUMAN Increases Expression [171]
Importin subunit alpha-1 (KPNA2) OTU7FOE6 IMA1_HUMAN Decreases Expression [171]
Stanniocalcin-1 (STC1) OTGVVXYF STC1_HUMAN Decreases Expression [171]
High mobility group protein HMGI-C (HMGA2) OTBMBHHL HMGA2_HUMAN Decreases Expression [171]
Serine/threonine-protein kinase PLK1 (PLK1) OTRZX45T PLK1_HUMAN Decreases Expression [171]
Microfibril-associated glycoprotein 4 (MFAP4) OT5W64QY MFAP4_HUMAN Increases Expression [171]
DNA polymerase epsilon subunit 2 (POLE2) OTAC9V6L DPOE2_HUMAN Decreases Expression [171]
Cyclin-dependent kinases regulatory subunit 1 (CKS1B) OTNUPLUJ CKS1_HUMAN Decreases Expression [171]
Transforming growth factor beta-2 proprotein (TGFB2) OTC0TXEP TGFB2_HUMAN Increases Expression [171]
Actin, aortic smooth muscle (ACTA2) OTEDLG8E ACTA_HUMAN Increases Expression [171]
Actin, gamma-enteric smooth muscle (ACTG2) OTRDWUO0 ACTH_HUMAN Increases Expression [171]
Actin, alpha cardiac muscle 1 (ACTC1) OTJU04B1 ACTC_HUMAN Increases Expression [171]
Protein jagged-1 (JAG1) OT3LGT6K JAG1_HUMAN Increases Expression [171]
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) OTEUYEW6 ROR1_HUMAN Increases Expression [171]
Centromere-associated protein E (CENPE) OTQ7AP04 CENPE_HUMAN Decreases Expression [171]
Kinesin-like protein KIF23 (KIF23) OTY850JC KIF23_HUMAN Decreases Expression [171]
Histone H1.1 (H1-1) OTSS815G H11_HUMAN Decreases Expression [171]
Aldehyde oxidase (AOX1) OT2FZP6H AOXA_HUMAN Decreases Expression [171]
DNA repair protein RAD51 homolog 1 (RAD51) OTNVWGC1 RAD51_HUMAN Decreases Expression [171]
Transcription factor SOX-4 (SOX4) OTSS40SS SOX4_HUMAN Increases Expression [171]
Prolow-density lipoprotein receptor-related protein 1 (LRP1) OTHTEH4G LRP1_HUMAN Increases Expression [171]
Forkhead box protein M1 (FOXM1) OT5887KR FOXM1_HUMAN Decreases Expression [171]
Lactadherin (MFGE8) OTQKE41R MFGM_HUMAN Increases Expression [171]
EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) OTZVUOOB FBLN3_HUMAN Increases Expression [171]
Cell division cycle protein 20 homolog (CDC20) OTCOEZRV CDC20_HUMAN Decreases Expression [171]
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) OTA0UNHM ECH1_HUMAN Increases Expression [171]
MAL-like protein (MALL) OTKGZ89D MALL_HUMAN Decreases Expression [171]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) OTXNGZCG MD2L1_HUMAN Decreases Expression [171]
Centromere protein R (ITGB3BP) OT6Q7GR3 CENPR_HUMAN Decreases Expression [171]
Origin recognition complex subunit 1 (ORC1) OTHWU8IJ ORC1_HUMAN Decreases Expression [171]
Limbic system-associated membrane protein (LSAMP) OTYXVQX2 LSAMP_HUMAN Increases Expression [171]
Four and a half LIM domains protein 1 (FHL1) OTN535SU FHL1_HUMAN Increases Expression [171]
Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C) OT6KFNMS CAC1C_HUMAN Increases Expression [171]
DNA polymerase alpha subunit B (POLA2) OTTWQ73N DPOA2_HUMAN Decreases Expression [171]
Fibroleukin (FGL2) OT8M3H72 FGL2_HUMAN Increases Expression [171]
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (PDE3A) OTKUW1WT PDE3A_HUMAN Increases Expression [171]
Semaphorin-3A (SEMA3A) OTQJSV7W SEM3A_HUMAN Decreases Expression [171]
DNA replication licensing factor MCM6 (MCM6) OTKLIAWT MCM6_HUMAN Decreases Expression [171]
Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) OTX7MWW1 ITPR1_HUMAN Increases Expression [171]
Maternal embryonic leucine zipper kinase (MELK) OTEY2UQA MELK_HUMAN Decreases Expression [171]
DNA replication complex GINS protein PSF1 (GINS1) OTVQZMMQ PSF1_HUMAN Decreases Expression [171]
Transmembrane glycoprotein NMB (GPNMB) OTB7KQKV GPNMB_HUMAN Increases Expression [171]
Condensin complex subunit 2 (NCAPH) OTXOS97C CND2_HUMAN Decreases Expression [171]
PCNA-associated factor (PCLAF) OTMVIOUU PAF15_HUMAN Decreases Expression [171]
Condensin complex subunit 1 (NCAPD2) OT8VGE2O CND1_HUMAN Decreases Expression [171]
Disks large-associated protein 5 (DLGAP5) OTWCN39U DLGP5_HUMAN Decreases Expression [171]
SCL-interrupting locus protein (STIL) OT9799VN STIL_HUMAN Decreases Expression [171]
Pachytene checkpoint protein 2 homolog (TRIP13) OTFM3TI9 PCH2_HUMAN Decreases Expression [171]
Myosin light chain kinase, smooth muscle (MYLK) OT78QB4A MYLK_HUMAN Increases Expression [171]
Histone-lysine N-methyltransferase EZH2 (EZH2) OTIEHTKW EZH2_HUMAN Decreases Expression [171]
Insulin-like growth factor-binding protein 7 (IGFBP7) OT1D416P IBP7_HUMAN Increases Expression [171]
Neuronal regeneration-related protein (NREP) OT2AZPKK NREP_HUMAN Increases Expression [171]
Prostacyclin synthase (PTGIS) OTT3RW6N PTGIS_HUMAN Increases Expression [171]
Cyclin-dependent kinase inhibitor 3 (CDKN3) OTBE3H07 CDKN3_HUMAN Decreases Expression [171]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Increases Expression [171]
Phosphoenolpyruvate carboxykinase , mitochondrial (PCK2) OTJ8LX4N PCKGM_HUMAN Increases Expression [171]
Tumor protein D53 (TPD52L1) OTSA6U0I TPD53_HUMAN Increases Expression [171]
Flap endonuclease GEN homolog 1 (GEN1) OT1XFQXF GEN_HUMAN Decreases Expression [171]
Mitochondrial 10-formyltetrahydrofolate dehydrogenase (ALDH1L2) OTCH86VF AL1L2_HUMAN Increases Expression [171]
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (SVEP1) OTOBICRD SVEP1_HUMAN Increases Expression [171]
Borealin (CDCA8) OT17D55D BOREA_HUMAN Decreases Expression [171]
Protein LBH (LBH) OT87AT1X LBH_HUMAN Increases Expression [171]
Shugoshin 2 (SGO2) OTNGJDS8 SGO2_HUMAN Decreases Expression [171]
Centromere protein W (CENPW) OTZL05QN CENPW_HUMAN Decreases Expression [171]
Shugoshin 1 (SGO1) OTIP6IRN SGO1_HUMAN Decreases Expression [171]
Probable E3 ubiquitin-protein ligase HERC4 (HERC4) OTU4DSDE HERC4_HUMAN Decreases Expression [171]
Testis-expressed protein 30 (TEX30) OT87WEPQ TEX30_HUMAN Decreases Expression [171]
DEP domain-containing protein 1A (DEPDC1) OT0JWE1B DEP1A_HUMAN Decreases Expression [171]
Tensin-3 (TNS3) OTPG2D8Z TENS3_HUMAN Increases Expression [171]
Cell division cycle-associated protein 2 (CDCA2) OTX8UF9J CDCA2_HUMAN Decreases Expression [171]
Protein FAM72D (FAM72D) OTCQVOXB FA72D_HUMAN Decreases Expression [171]
Repulsive guidance molecule B (RGMB) OT2DROYU RGMB_HUMAN Decreases Expression [171]
STEAP family member 1B (STEAP1B) OTZJDFWK STEAL_HUMAN Decreases Expression [171]
Mis18-binding protein 1 (MIS18BP1) OT41T0FB M18BP_HUMAN Decreases Expression [171]
Mitochondrial fission regulator 2 (MTFR2) OTLOR68D MTFR2_HUMAN Decreases Expression [171]
Rho GTPase-activating protein 11A (ARHGAP11A) OTVQCFVP RHGBA_HUMAN Decreases Expression [171]
E3 ubiquitin-protein ligase RFWD3 (RFWD3) OTDUULBQ RFWD3_HUMAN Decreases Expression [171]
Podocan-like protein 1 (PODNL1) OTL72ES9 PONL1_HUMAN Increases Expression [171]
Protein aurora borealis (BORA) OTV2ZPKP BORA_HUMAN Decreases Expression [171]
Neutral cholesterol ester hydrolase 1 (NCEH1) OTZ66CKX NCEH1_HUMAN Decreases Expression [171]
Fidgetin-like protein 1 (FIGNL1) OTKII63K FIGL1_HUMAN Decreases Expression [171]
ATPase family AAA domain-containing protein 2 (ATAD2) OT8MCRNY ATAD2_HUMAN Decreases Expression [171]
Serine protease FAM111B (FAM111B) OT9IQ9NV F111B_HUMAN Decreases Expression [171]
Protein FAM180A (FAM180A) OTKQ7XUG F180A_HUMAN Decreases Expression [171]
Golgi-associated kinase 1B (GASK1B) OT2HPHEI GAK1B_HUMAN Increases Expression [171]
Plexin domain-containing protein 2 (PLXDC2) OTS1FUV6 PXDC2_HUMAN Increases Expression [171]
ALK and LTK ligand 1 (ALKAL1) OTZGAZ79 ALKL1_HUMAN Increases Expression [171]
Protein MMS22-like (MMS22L) OTJI0HM9 MMS22_HUMAN Decreases Expression [171]
Centrosomal protein of 128 kDa (CEP128) OT922YCJ CE128_HUMAN Decreases Expression [171]
DNA-binding protein RFX8 (RFX8) OT27SFGQ RFX8_HUMAN Decreases Expression [171]
Centromere protein U (CENPU) OTQ4TZRS CENPU_HUMAN Decreases Expression [171]
Protein MCM10 homolog (MCM10) OTV0O3JN MCM10_HUMAN Decreases Expression [171]
Treslin (TICRR) OT2HKWOC TICRR_HUMAN Decreases Expression [171]
MAM domain-containing protein 2 (MAMDC2) OT4GICNY MAMC2_HUMAN Increases Expression [171]
LisH domain-containing protein ARMC9 (ARMC9) OT0MZER2 ARMC9_HUMAN Increases Expression [171]
Rho GTPase-activating protein 22 (ARHGAP22) OTXUQEFL RHG22_HUMAN Decreases Expression [171]
Podocan (PODN) OTV3P7P5 PODN_HUMAN Increases Expression [171]
Schlafen family member 11 (SLFN11) OTJWFPMY SLN11_HUMAN Decreases Expression [171]
Amphoterin-induced protein 2 (AMIGO2) OTPAIT1O AMGO2_HUMAN Increases Expression [171]
Alpha-protein kinase 2 (ALPK2) OTWZZDQ9 ALPK2_HUMAN Increases Expression [171]
Myopalladin (MYPN) OTHTOFDU MYPN_HUMAN Decreases Expression [171]
E3 ubiquitin-protein ligase MARCHF3 (MARCHF3) OT89V4N5 MARH3_HUMAN Decreases Expression [171]
Ras GTPase-activating-like protein IQGAP3 (IQGAP3) OT4RZV2M IQGA3_HUMAN Decreases Expression [171]
Condensin-2 complex subunit G2 (NCAPG2) OTZYENKO CNDG2_HUMAN Decreases Expression [171]
GAS2-like protein 3 (GAS2L3) OTWPVI29 GA2L3_HUMAN Decreases Expression [171]
Histone H2A type 2-B (H2AC21) OTH7W2NJ H2A2B_HUMAN Decreases Expression [171]
Pleckstrin homology domain-containing family H member 2 (PLEKHH2) OT3TK3NN PKHH2_HUMAN Increases Expression [171]
Extracellular sulfatase Sulf-2 (SULF2) OTIXMUVL SULF2_HUMAN Increases Expression [171]
Extracellular sulfatase Sulf-1 (SULF1) OTJCNCO0 SULF1_HUMAN Increases Expression [171]
CD302 antigen (CD302) OTX580VU CD302_HUMAN Increases Expression [171]
Spindle and kinetochore-associated protein 3 (SKA3) OTLHEVJD SKA3_HUMAN Decreases Expression [171]
DNA damage-induced apoptosis suppressor protein (DDIAS) OTTGG2PM DDIAS_HUMAN Decreases Expression [171]
Cytoskeleton-associated protein 2-like (CKAP2L) OT4T73GG CKP2L_HUMAN Decreases Expression [171]
Fanconi anemia group M protein (FANCM) OTNJG99Z FANCM_HUMAN Decreases Expression [171]
Lung adenoma susceptibility protein 2 (C18ORF54) OT4WJKTF LAS2_HUMAN Decreases Expression [171]
Abnormal spindle-like microcephaly-associated protein (ASPM) OTKXQMNA ASPM_HUMAN Decreases Expression [171]
Retinol dehydrogenase 10 (RDH10) OTL9FSGF RDH10_HUMAN Increases Expression [171]
Centromere protein L (CENPL) OT7P006B CENPL_HUMAN Decreases Expression [171]
Rho GTPase-activating protein 18 (ARHGAP18) OTYMJP6H RHG18_HUMAN Decreases Expression [171]
T-complex protein 11-like protein 2 (TCP11L2) OTTIZO7B T11L2_HUMAN Increases Expression [171]
Aminopeptidase O (AOPEP) OT0MMANL AMPO_HUMAN Increases Expression [171]
Junction-mediating and -regulatory protein (JMY) OTH5FFVK JMY_HUMAN Increases Expression [171]
Holliday junction recognition protein (HJURP) OTWMV16B HJURP_HUMAN Decreases Expression [171]
SHC SH2 domain-binding protein 1 (SHCBP1) OT3A21CM SHCBP_HUMAN Decreases Expression [171]
MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (MDGA1) OTVXEF85 MDGA1_HUMAN Increases Expression [171]
(Lyso)-N-acylphosphatidylethanolamine lipase (ABHD4) OTQK3M9X ABHD4_HUMAN Increases Expression [171]
DEP domain-containing mTOR-interacting protein (DEPTOR) OTCBP1BT DPTOR_HUMAN Increases Expression [171]
Protein CIP2A (CIP2A) OTVS2GXA CIP2A_HUMAN Decreases Expression [171]
Sodium-dependent phosphate transporter 1 (SLC20A1) OTC3D894 S20A1_HUMAN Decreases Expression [171]
DEP domain-containing protein 1B (DEPDC1B) OTMVFOT1 DEP1B_HUMAN Decreases Expression [171]
Basic helix-loop-helix ARNT-like protein 2 (BMAL2) OTIBDGQC BMAL2_HUMAN Decreases Expression [171]
Centromere protein I (CENPI) OTWRIMZ3 CENPI_HUMAN Decreases Expression [171]
Serine protease HTRA1 (HTRA1) OTR8ACBF HTRA1_HUMAN Increases Expression [171]
Hyaluronan synthase 2 (HAS2) OTTD3PAL HYAS2_HUMAN Decreases Expression [171]
Neogenin (NEO1) OTGJ1997 NEO1_HUMAN Increases Expression [171]
Histone H2B type 1-H (H2BC9) OTQ9XX72 H2B1H_HUMAN Decreases Expression [171]
F-box only protein 32 (FBXO32) OTUE978R FBX32_HUMAN Increases Expression [171]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1) OT2363Z9 T53I1_HUMAN Increases Expression [171]
Transcription factor E2F7 (E2F7) OTWW358N E2F7_HUMAN Decreases Expression [171]
Spindle and kinetochore-associated protein 1 (SKA1) OTDYJ12A SKA1_HUMAN Decreases Expression [171]
Mdm2-binding protein (MTBP) OTWLCW9C MTBP_HUMAN Decreases Expression [171]
Sororin (CDCA5) OTZLCQ5U CDCA5_HUMAN Decreases Expression [171]
Aurora kinase B (AURKB) OTIY4VHU AURKB_HUMAN Decreases Expression [171]
Serine/threonine-protein kinase greatwall (MASTL) OTQ7YKK5 GWL_HUMAN Decreases Expression [171]
Centromere protein N (CENPN) OTRO7XPD CENPN_HUMAN Decreases Expression [171]
Proline-rich protein 11 (PRR11) OT2JJ08Z PRR11_HUMAN Decreases Expression [171]
Lymphokine-activated killer T-cell-originated protein kinase (PBK) OT5Z27TW TOPK_HUMAN Decreases Expression [171]
Leucine-rich repeat protein 1 (LRR1) OTSWDXVY LLR1_HUMAN Decreases Expression [171]
Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 (PCMTD1) OT5TS6P7 PCMD1_HUMAN Increases Expression [171]
Discoidin, CUB and LCCL domain-containing protein 2 (DCBLD2) OTB71I02 DCBD2_HUMAN Decreases Expression [171]
Kinesin-like protein KIF20B (KIF20B) OTS68AHH KI20B_HUMAN Decreases Expression [171]
ATPase family AAA domain-containing protein 5 (ATAD5) OTI8ABKF ATAD5_HUMAN Decreases Expression [171]
Hemicentin-1 (HMCN1) OTLZAS0P HMCN1_HUMAN Increases Expression [171]
Hyaluronan and proteoglycan link protein 3 (HAPLN3) OTB853Z1 HPLN3_HUMAN Increases Expression [171]
Proheparin-binding EGF-like growth factor (HBEGF) OTLU00JS HBEGF_HUMAN Decreases Expression [171]
Cell division cycle-associated protein 3 (CDCA3) OTUI8QK3 CDCA3_HUMAN Decreases Expression [171]
Kinesin-like protein KIF2C (KIF2C) OTJ8G3NP KIF2C_HUMAN Decreases Expression [171]
Cell division control protein 6 homolog (CDC6) OTX93FE7 CDC6_HUMAN Decreases Expression [171]
Endothelial PAS domain-containing protein 1 (EPAS1) OTRE3O8U EPAS1_HUMAN Increases Expression [171]
Histone H2B type 1-M (H2BC14) OTSDZZZY H2B1M_HUMAN Decreases Expression [171]
Condensin complex subunit 3 (NCAPG) OT1AI9EO CND3_HUMAN Decreases Expression [171]
Mitochondrial genome maintenance exonuclease 1 (MGME1) OTC5LPXX MGME1_HUMAN Decreases Expression [171]
Synaptotagmin-15 (SYT15) OT7Q088G SYT15_HUMAN Increases Expression [171]
Hephaestin (HEPH) OTZ2F15Z HEPH_HUMAN Increases Expression [171]
DNA replication complex GINS protein SLD5 (GINS4) OTCVOO3S SLD5_HUMAN Decreases Expression [171]
Centromere protein K (CENPK) OTKPUF8K CENPK_HUMAN Decreases Expression [171]
Protein PIMREG (PIMREG) OTKC8T3E PIMRE_HUMAN Decreases Expression [171]
Nucleoporin NDC1 (NDC1) OTF2GQC1 NDC1_HUMAN Decreases Expression [171]
Centromere protein O (CENPO) OTXAH83Y CENPO_HUMAN Decreases Expression [171]
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) OTJGE772 CHAC1_HUMAN Increases Expression [171]
TIMELESS-interacting protein (TIPIN) OT9PZHXV TIPIN_HUMAN Decreases Expression [171]
Kinesin-like protein KIFC1 (KIFC1) OTNQDS00 KIFC1_HUMAN Decreases Expression [171]
Meiotic nuclear division protein 1 homolog (MND1) OTS87F3H MND1_HUMAN Decreases Expression [171]
Nucleolar and spindle-associated protein 1 (NUSAP1) OT85HIJ5 NUSAP_HUMAN Decreases Expression [171]
Fanconi anemia group D2 protein (FANCD2) OTVEB5LF FACD2_HUMAN Decreases Expression [171]
Transmembrane 6 superfamily member 1 (TM6SF1) OTQR4I2N TM6S1_HUMAN Increases Expression [171]
Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2) OTVSFHTL CRLD2_HUMAN Increases Expression [171]
Rac GTPase-activating protein 1 (RACGAP1) OTQE8IEH RGAP1_HUMAN Decreases Expression [171]
Centromere protein H (CENPH) OTPOO9LK CENPH_HUMAN Decreases Expression [171]
Kinetochore-associated protein DSN1 homolog (DSN1) OTHROI0H DSN1_HUMAN Decreases Expression [171]
Uncharacterized protein C1orf198 (C1ORF198) OTK3L4G7 CA198_HUMAN Increases Expression [171]
Golgi-associated plant pathogenesis-related protein 1 (GLIPR2) OTFTH6ZY GAPR1_HUMAN Increases Expression [171]
Very long chain fatty acid elongase 6 (ELOVL6) OTB26UJJ ELOV6_HUMAN Decreases Expression [171]
Anthrax toxin receptor 1 (ANTXR1) OT5W1GPC ANTR1_HUMAN Increases Expression [171]
Gremlin-2 (GREM2) OTE91EWT GREM2_HUMAN Increases Expression [171]
Metal transporter CNNM2 (CNNM2) OTZHO8WU CNNM2_HUMAN Increases Expression [171]
Protein ECT2 (ECT2) OTQDUCT6 ECT2_HUMAN Decreases Expression [171]
Claspin (CLSPN) OTZZXNDK CLSPN_HUMAN Decreases Expression [171]
Mineralization regulator ANKH (ANKH) OTCN25R5 ANKH_HUMAN Increases Expression [171]
Ribonucleoprotein PTB-binding 2 (RAVER2) OT0MDL7K RAVR2_HUMAN Increases Expression [171]
Neurexin-3-beta (NRXN3) OTJ0I7HJ NRX3B_HUMAN Increases Expression [171]
Solute carrier family 40 member 1 (SLC40A1) OT8RV2VY S40A1_HUMAN Increases Expression [171]
Anillin (ANLN) OTXJY54C ANLN_HUMAN Decreases Expression [171]
Phospholipid scramblase 4 (PLSCR4) OT2AMYLY PLS4_HUMAN Increases Expression [171]
Lymphoid-specific helicase (HELLS) OTVVV668 HELLS_HUMAN Decreases Expression [171]
FIGNL1-interacting regulator of recombination and mitosis (FIRRM) OTALLHT1 FIRRM_HUMAN Decreases Expression [171]
Protein diaphanous homolog 3 (DIAPH3) OTPOT23F DIAP3_HUMAN Decreases Expression [171]
Structural maintenance of chromosomes protein 4 (SMC4) OTEJE6AG SMC4_HUMAN Decreases Expression [171]
Protein DEPP1 (DEPP1) OTB36PHJ DEPP1_HUMAN Increases Expression [171]
Tyrosyl-DNA phosphodiesterase 1 (TDP1) OTYINMBR TYDP1_HUMAN Decreases Expression [171]
Fanconi anemia group I protein (FANCI) OTW8E3SC FANCI_HUMAN Decreases Expression [171]
Histone chaperone ASF1B (ASF1B) OTKXX12I ASF1B_HUMAN Decreases Expression [171]
PCNA-interacting partner (PARPBP) OTPZDGW7 PARI_HUMAN Decreases Expression [171]
DNA damage-inducible transcript 4 protein (DDIT4) OTHY8SY4 DDIT4_HUMAN Increases Expression [171]
Dapper homolog 1 (DACT1) OT19Z704 DACT1_HUMAN Increases Expression [171]
Protein Mis18-alpha (MIS18A) OTD80K5X MS18A_HUMAN Decreases Expression [171]
Denticleless protein homolog (DTL) OTC29RYE DTL_HUMAN Decreases Expression [171]
Programmed cell death 1 ligand 1 (CD274) OTJ0VFDL PD1L1_HUMAN Decreases Expression [171]
LIM and cysteine-rich domains protein 1 (LMCD1) OT3AWE8O LMCD1_HUMAN Increases Expression [171]
Calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1) OT1PAIN0 CACO1_HUMAN Increases Expression [171]
Homologous-pairing protein 2 homolog (PSMC3IP) OT9UB5UO HOP2_HUMAN Decreases Expression [171]
Fibulin-5 (FBLN5) OTLVNZ8U FBLN5_HUMAN Increases Expression [171]
DNA dC->dU-editing enzyme APOBEC-3B (APOBEC3B) OTHLNI51 ABC3B_HUMAN Decreases Expression [171]
STEAP1 protein (STEAP1) OTJMW5R9 STEA1_HUMAN Decreases Expression [171]
Carboxypeptidase A4 (CPA4) OT66MP0F CBPA4_HUMAN Decreases Expression [171]
DNA helicase MCM8 (MCM8) OTC93H3S MCM8_HUMAN Decreases Expression [171]
F-box only protein 5 (FBXO5) OTTR957W FBX5_HUMAN Decreases Expression [171]
Angiopoietin-related protein 2 (ANGPTL2) OTB6JG41 ANGL2_HUMAN Increases Expression [171]
Integrin alpha-11 (ITGA11) OTBWSRA1 ITA11_HUMAN Increases Expression [171]
Protein HEG homolog 1 (HEG1) OT3CUXA7 HEG1_HUMAN Increases Expression [171]
Targeting protein for Xklp2 (TPX2) OTWLJYH0 TPX2_HUMAN Decreases Expression [171]
Synaptopodin-2 (SYNPO2) OTC3U0YH SYNP2_HUMAN Increases Expression [171]
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) OT953SV2 ATS5_HUMAN Increases Expression [171]
Protein timeless homolog (TIMELESS) OTD8DCBJ TIM_HUMAN Decreases Expression [171]
LIM and calponin homology domains-containing protein 1 (LIMCH1) OTYPC4XA LIMC1_HUMAN Increases Expression [171]
Exonuclease 1 (EXO1) OTI87RS5 EXO1_HUMAN Decreases Expression [171]
Protein phosphatase 1 regulatory subunit 3C (PPP1R3C) OTEU05TX PPR3C_HUMAN Increases Expression [171]
Transcription factor 19 (TCF19) OT7NKLF9 TCF19_HUMAN Decreases Expression [171]
DNA replication complex GINS protein PSF2 (GINS2) OT974IYI PSF2_HUMAN Decreases Expression [171]
Serine/threonine-protein kinase 38-like (STK38L) OTI00JVW ST38L_HUMAN Increases Expression [171]
Small kinetochore-associated protein (KNSTRN) OTYA7UXS SKAP_HUMAN Decreases Expression [171]
Origin recognition complex subunit 6 (ORC6) OTKQN3KP ORC6_HUMAN Decreases Expression [171]
Phosphoserine aminotransferase (PSAT1) OTVV1YV9 SERC_HUMAN Increases Expression [171]
Carboxypeptidase Q (CPQ) OTTNZNLD CBPQ_HUMAN Increases Expression [171]
Transforming acidic coiled-coil-containing protein 3 (TACC3) OTRNEZTA TACC3_HUMAN Decreases Expression [171]
Inositol 1,4,5-triphosphate receptor associated 1 (IRAG1) OTMRW5U5 IRAG1_HUMAN Increases Expression [171]
Adenylate kinase isoenzyme 5 (AK5) OTTGXLOT KAD5_HUMAN Decreases Expression [171]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Decreases Activity [179]
Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) OTFBFPV4 ADAS_HUMAN Increases Expression [180]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Decreases Expression [180]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [180]
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) OT5BZ1J9 P85A_HUMAN Decreases Phosphorylation [180]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Decreases Phosphorylation [180]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Decreases Expression [180]
cAMP-regulated phosphoprotein 19 (ARPP19) OTZS3IT6 ARP19_HUMAN Increases Expression [180]
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) OTPGHZB9 IFIT3_HUMAN Increases Expression [181]
Apoptosis-inducing factor 1, mitochondrial (AIFM1) OTKPWB7Q AIFM1_HUMAN Affects Localization [182]
Tyrosine-protein kinase ABL1 (ABL1) OT09YVXH ABL1_HUMAN Decreases Activity [183]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [181]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Decreases Activity [184]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Decreases Expression [185]
Interferon gamma (IFNG) OTXG9JM7 IFNG_HUMAN Decreases Expression [185]
C-X-C motif chemokine 10 (CXCL10) OTTLQ6S0 CXL10_HUMAN Increases Expression [181]
Granulocyte-macrophage colony-stimulating factor (CSF2) OT1M7D28 CSF2_HUMAN Decreases Expression [185]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Decreases Activity [186]
Interleukin-5 (IL5) OTAFPSCO IL5_HUMAN Decreases Expression [185]
Cathepsin B (CTSB) OTP9G5QB CATB_HUMAN Decreases Expression [187]
Tyrosine-protein kinase Lyn (LYN) OTP686K2 LYN_HUMAN Decreases Activity [172]
Hepatocyte growth factor receptor (MET) OT7K55MU MET_HUMAN Decreases Phosphorylation [188]
Growth-regulated alpha protein (CXCL1) OT3WCTZV GROA_HUMAN Decreases Expression [185]
High mobility group protein B1 (HMGB1) OT4B7CPF HMGB1_HUMAN Increases Expression [189]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Decreases Activity [187]
C-C motif chemokine 3 (CCL3) OTW2H3ND CCL3_HUMAN Decreases Expression [185]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [190]
Mast/stem cell growth factor receptor Kit (KIT) OTHUY3VZ KIT_HUMAN Decreases Phosphorylation [191]
Integrin alpha-M (ITGAM) OTAG6HWU ITAM_HUMAN Increases Expression [181]
Breakpoint cluster region protein (BCR) OTCN76C1 BCR_HUMAN Decreases Activity [183]
C-C motif chemokine 4 (CCL4) OT6B8P25 CCL4_HUMAN Decreases Expression [185]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Decreases Activity [187]
C-C motif chemokine 5 (CCL5) OTSCA5CK CCL5_HUMAN Decreases Expression [185]
Interleukin-1 receptor type 1 (IL1R1) OTTU8959 IL1R1_HUMAN Decreases Expression [185]
Platelet-derived growth factor receptor alpha (PDGFRA) OTDJXUCN PGFRA_HUMAN Decreases Phosphorylation [192]
C-C motif chemokine 1 (CCL1) OT23NON8 CCL1_HUMAN Decreases Expression [185]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Decreases Expression [193]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Phosphorylation [172]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Phosphorylation [172]
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) OTG0TTX7 CD38_HUMAN Decreases Expression [185]
G1/S-specific cyclin-D3 (CCND3) OTNKPQ22 CCND3_HUMAN Decreases Expression [193]
Receptor-type tyrosine-protein kinase FLT3 (FLT3) OTMSRYMK FLT3_HUMAN Decreases Phosphorylation [191]
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Decreases Phosphorylation [194]
Serine/threonine-protein kinase mTOR (MTOR) OTHH8KU7 MTOR_HUMAN Decreases Phosphorylation [190]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [183]
Tyrosine-protein kinase ABL2 (ABL2) OTS8F4GD ABL2_HUMAN Affects Binding [195]
Crk-like protein (CRKL) OTOYSD1R CRKL_HUMAN Decreases Phosphorylation [196]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Increases Expression [193]
Stromal cell-derived factor 1 (CXCL12) OT2QX5LL SDF1_HUMAN Decreases Expression [185]
Paxillin (PXN) OTVMMUOF PAXI_HUMAN Decreases Phosphorylation [194]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Increases Cleavage [172]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Activity [197]
Interleukin-2 (IL2) OTGI4NSA IL2_HUMAN Decreases Expression [185]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Decreases Phosphorylation [185]
Mothers against decapentaplegic homolog 3 (SMAD3) OTNA96MR SMAD3_HUMAN Decreases Phosphorylation [184]
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1) OT4Y9NQI MP2K1_HUMAN Increases Phosphorylation [181]
Focal adhesion kinase 1 (PTK2) OT3Q1JDY FAK1_HUMAN Decreases Phosphorylation [193]
Early activation antigen CD69 (CD69) OTGJHSVP CD69_HUMAN Decreases Expression [185]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [172]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Decreases Expression [172]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Activity [197]
Pre-mRNA 3'-end-processing factor FIP1 (FIP1L1) OTF91GTL FIP1_HUMAN Decreases Phosphorylation [192]
Bile acid receptor (NR1H4) OTWZLPTB NR1H4_HUMAN Decreases Phosphorylation [198]
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1) OTYRXD2T PMYT1_HUMAN Decreases Activity [199]
Transcription factor SOX-17 (SOX17) OT9H4WWE SOX17_HUMAN Decreases Localization [200]
Diablo IAP-binding mitochondrial protein (DIABLO) OTHJ9MCZ DBLOH_HUMAN Affects Localization [182]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Increases Response To Substance [193]
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL) OTK3EJFD NSDHL_HUMAN Decreases Response To Substance [201]
Methylsterol monooxygenase 1 (MSMO1) OTKV62RZ MSMO1_HUMAN Decreases Response To Substance [201]
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⏷ Show the Full List of 453 DOT(s)

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Adenocarcinoma DC3VSIP COLO320DM Investigative [202]
Adenocarcinoma DCADKI9 DLD1 Investigative [202]
Adenocarcinoma DC1PTVD HT29 Investigative [202]
Adenocarcinoma DCMJ4QJ SW-620 Investigative [202]
Breast and ovarian cancer syndrome DCPGDU7 UWB1289 Investigative [203]
Breast and ovarian cancer syndrome DCSRGQ8 UWB1289+BRCA1 Investigative [203]
Breast carcinoma DCTGQMW KPL1 Investigative [203]
Breast carcinoma DCFAKLL OCUBM Investigative [203]
Carcinoma DC73FQA OV90 Investigative [203]
Carcinoma DCNJBAF EFM192B Investigative [203]
Carcinoma DCK2KXI MDAMB436 Investigative [203]
Colon adenocarcinoma DC74B5F LOVO Investigative [203]
Rectal adenocarcinoma DCCF4DR SW837 Investigative [203]
Adenocarcinoma DCS1FGD CAOV3 Investigative [1]
Adenocarcinoma DCR36T2 OVCAR3 Investigative [1]
Adenocarcinoma DCLZP7J A427 Investigative [1]
Adenocarcinoma DC7PK1R NCIH23 Investigative [1]
Adenocarcinoma DC3SSLW NCIH520 Investigative [1]
Amelanotic melanoma DCVPOSZ A2058 Investigative [1]
Germ cell tumour DCBM1I7 PA1 Investigative [1]
Malignant melanoma DC4HPQT A375 Investigative [1]
Malignant melanoma DCYM085 RPMI7951 Investigative [1]
Mesothelioma DCJ4DG3 MSTO Investigative [1]
Non small cell carcinoma DC4CFT1 SKMES1 Investigative [1]
Ovarian endometrioid adenocarcinoma DCKEGOE A2780 Investigative [1]
Prostate carcinoma DCHOLHX LNCAP Investigative [1]
Prostate carcinoma DC36HKG VCAP Investigative [1]
------------------------------------------------------------------------------------
⏷ Show the Full List of 27 DrugCom(s)

References

1 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
2 Fluorouracil FDA Label
3 Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
4 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
5 Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207.
6 Dasatinib FDA Label
7 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5678).
8 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
9 Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47.
10 Influence of chemotherapeutic agents and cytokines on the expression of 5-fluorouracil-associated enzymes in human colon cancer cell lines. J Gastroenterol. 2006 Feb;41(2):140-50.
11 Comparison of gene expression in HCT116 treatment derivatives generated by two different 5-fluorouracil exposure protocols. Mol Cancer. 2004 Apr 26;3:11.
12 Thymidylate synthase pharmacogenetics. Invest New Drugs. 2005 Dec;23(6):533-7. doi: 10.1007/s10637-005-4021-7.
13 Orotate phosphoribosyltransferase expression level in tumors is a potential determinant of the efficacy of 5-fluorouracil. Biochem Biophys Res Commun. 2007 Nov 9;363(1):216-22. doi: 10.1016/j.bbrc.2007.08.164. Epub 2007 Sep 6.
14 Cell-type-specific responses to chemotherapeutics in breast cancer. Cancer Res. 2004 Jun 15;64(12):4218-26.
15 Identification of novel genes associated with the response to 5-FU treatment in gastric cancer cell lines using a cDNA microarray. Cancer Lett. 2004 Oct 8;214(1):19-33.
16 Proteomic analysis of antiproliferative effects by treatment of 5-fluorouracil in cervical cancer cells. DNA Cell Biol. 2004 Nov;23(11):769-76.
17 Pharmacogenomic identification of novel determinants of response to chemotherapy in colon cancer. Cancer Res. 2006 Mar 1;66(5):2765-77.
18 Transcriptional profiling of MCF7 breast cancer cells in response to 5-Fluorouracil: relationship with cell cycle changes and apoptosis, and identification of novel targets of p53. Int J Cancer. 2006 Sep 1;119(5):1164-75.
19 Analysis of the in vitro synergistic effect of 5-fluorouracil and cisplatin on cervical carcinoma cells. Int J Gynecol Cancer. 2006 May-Jun;16(3):1321-9.
20 Gene expression profiling of breast cancer cells in response to gemcitabine: NF-kappaB pathway activation as a potential mechanism of resistance. Breast Cancer Res Treat. 2007 Apr;102(2):157-72.
21 Apoptosis, cell cycle progression and gene expression in TP53-depleted HCT116 colon cancer cells in response to short-term 5-fluorouracil treatment. Int J Oncol. 2007 Dec;31(6):1491-500.
22 Expression profiling of nucleotide metabolism-related genes in human breast cancer cells after treatment with 5-fluorouracil. Cancer Invest. 2009 Jun;27(5):561-7.
23 Evaluation of developmental toxicity using undifferentiated human embryonic stem cells. J Appl Toxicol. 2015 Feb;35(2):205-18.
24 New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids. Arch Toxicol. 2021 Aug;95(8):2691-2718. doi: 10.1007/s00204-021-03092-2. Epub 2021 Jun 20.
25 Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancer. BMC Genomics. 2006 Apr 3;7:68. doi: 10.1186/1471-2164-7-68.
26 Dissecting progressive stages of 5-fluorouracil resistance in vitro using RNA expression profiling. Int J Cancer. 2004 Nov 1;112(2):200-12. doi: 10.1002/ijc.20401.
27 Resveratrol induces chemosensitization to 5-fluorouracil through up-regulation of intercellular junctions, Epithelial-to-mesenchymal transition and apoptosis in colorectal cancer. Biochem Pharmacol. 2015 Nov 1;98(1):51-68. doi: 10.1016/j.bcp.2015.08.105. Epub 2015 Aug 24.
28 Fluorodeoxyuridine modulates cellular expression of the DNA base excision repair enzyme uracil-DNA glycosylase. Cancer Res. 2006 Sep 1;66(17):8829-37. doi: 10.1158/0008-5472.CAN-06-0540.
29 Exposure-based assessment of chemical teratogenicity using morphogenetic aggregates of human embryonic stem cells. Reprod Toxicol. 2020 Jan;91:74-91. doi: 10.1016/j.reprotox.2019.10.004. Epub 2019 Nov 8.
30 Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery. Mol Cancer. 2006 May 18;5:20. doi: 10.1186/1476-4598-5-20.
31 Novel proapoptotic agent SM-1 enhances the inhibitory effect of 5-fluorouracil on colorectal cancer cells in vitro and in vivo. Oncol Lett. 2017 Jun;13(6):4762-4768. doi: 10.3892/ol.2017.6043. Epub 2017 Apr 19.
32 Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
33 Identification of XAF1-MT2A mutual antagonism as a molecular switch in cell-fate decisions under stressful conditions. Proc Natl Acad Sci U S A. 2017 May 30;114(22):5683-5688. doi: 10.1073/pnas.1700861114. Epub 2017 May 15.
34 5-Fluorouracil up-regulates interferon pathway gene expression in esophageal cancer cells. Anticancer Res. 2005 Sep-Oct;25(5):3271-8.
35 Rare sugar D-allose enhances anti-tumor effect of 5-fluorouracil on the human hepatocellular carcinoma cell line HuH-7. J Biosci Bioeng. 2008 Sep;106(3):248-52. doi: 10.1263/jbb.106.248.
36 The previously undescribed ZKSCAN3 (ZNF306) is a novel "driver" of colorectal cancer progression. Cancer Res. 2008 Jun 1;68(11):4321-30. doi: 10.1158/0008-5472.CAN-08-0407.
37 Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
38 Mechanistic and predictive profiling of 5-Fluorouracil resistance in human cancer cells. Cancer Res. 2004 Nov 15;64(22):8167-76. doi: 10.1158/0008-5472.CAN-04-0970.
39 Arsenic trioxide reverses the chemoresistance in hepatocellular carcinoma: a targeted intervention of 14-3-3/NF-B feedback loop. J Exp Clin Cancer Res. 2018 Dec 20;37(1):321. doi: 10.1186/s13046-018-1005-y.
40 Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer. Sci Transl Med. 2011 Jan 26;3(67):67ra7. doi: 10.1126/scitranslmed.3001922.
41 HCRP1 inhibits cell proliferation and invasion and promotes chemosensitivity in esophageal squamous cell carcinoma. Chem Biol Interact. 2019 Aug 1;308:357-363. doi: 10.1016/j.cbi.2019.05.032. Epub 2019 May 29.
42 The efficacy of the combination therapy of 5-fluorouracil, cisplatin and leucovorin for hepatocellular carcinoma and its predictable factors. Cancer Chemother Pharmacol. 2004 Apr;53(4):296-304.
43 Enhancement of the antitumour activity of 5-fluorouracil (5-FU) by inhibiting dihydropyrimidine dehydrogenase activity (DPD) using 5-chloro-2,4-dihydroxypyridine (CDHP) in human tumour cells. Eur J Cancer. 2002 Jun;38(9):1271-7.
44 Enhancing chemosensitivity in oral squamous cell carcinoma by lentivirus vector-mediated RNA interference targeting EGFR and MRP2. Oncol Lett. 2016 Sep;12(3):2107-2114.
45 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
46 Role of BCRP as a biomarker for predicting resistance to 5-fluorouracil in breast cancer. Cancer Chemother Pharmacol. 2009 May;63(6):1103-10.
47 Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]). J Pharm Pharmacol. 2005 May;57(5):573-8.
48 ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. Pancreatology. 2009;9(1-2):136-44.
49 Human equilibrative nucleoside transporter 1, as a predictor of 5-fluorouracil resistance in human pancreatic cancer. Anticancer Res. 2007 Jul-Aug;27(4B):2241-9.
50 Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes. Drug Metab Dispos. 2000 Dec;28(12):1457-63.
51 5-Fluorouracil toxicity-attributable IVS14 + 1G > A mutation of the dihydropyrimidine dehydrogenase gene in Polish colorectal cancer patients. Pharmacol Rep. 2008 Mar-Apr;60(2):238-42.
52 5-Fluorouracil pharmacogenomics: still rocking after all these years? Pharmacogenomics. 2011 Feb;12(2):251-65.
53 PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150653776)
54 Orotate phosphoribosyltransferase is overexpressed in malignant pleural mesothelioma: Dramatically responds one case in high OPRT expression. Rare Dis. 2016 Apr 5;4(1):e1165909.
55 Uridine phosphorylase in breast cancer: a new prognostic factor? Front Biosci. 2006 Sep 1;11:2759-66.
56 Combined suicide gene therapy for human colon cancer cells using adenovirus-mediated transfer of escherichia coli cytosine deaminase gene and Escherichia coli uracil phosphoribosyltransferase gene with 5-fluorocytosine. Cancer Gene Ther. 2000 Jul;7(7):1015-22.
57 Expression of CYP2A6 in tumor cells augments cellular sensitivity to tegafur. Jpn J Cancer Res. 2001 May;92(5):524-8. doi: 10.1111/j.1349-7006.2001.tb01125.x.
58 Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in normal tissue as predictors of fluorouracil sensitivity. J Clin Oncol. 2005 Mar 1;23(7):1365-9. doi: 10.1200/JCO.2005.06.219.
59 Heterozygosity for a point mutation in an invariant splice donor site of dihydropyrimidine dehydrogenase and severe 5-fluorouracil related toxicity. Eur J Cancer. 1997 Nov;33(13):2258-64. doi: 10.1016/s0959-8049(97)00261-x.
60 Schedule-dependent cytotoxicity of 5-fluorouracil and irinotecan in a colon cancer cell line. J Gastroenterol. 2006 Dec;41(12):1149-57.
61 Schedule-dependent therapeutic effects of gemcitabine combined with uracil-tegafur in a human pancreatic cancer xenograft model. Pancreas. 2006 Aug;33(2):142-7. doi: 10.1097/01.mpa.0000226882.48204.26.
62 Mechanism of apoptotic effects induced by 5-fluorouracil on human liver carcinoma Bel7402 cell line. Chin Med J (Engl). 2002 Jul;115(7):968-71.
63 5-Fluorouracil: identification of novel downstream mediators of tumour response. Anticancer Res. 2004 Mar-Apr;24(2A):417-23.
64 Regulation of human peptide transporter 1 (PEPT1) in gastric cancer cells by anticancer drugs. Cancer Lett. 2005 Dec 8;230(1):72-80.
65 Inhibition of Src tyrosine kinase reverts chemoresistance toward 5-fluorouracil in human pancreatic carcinoma cells: an involvement of epidermal growth factor receptor signaling. Oncogene. 2008 Dec 4;27(57):7212-22.
66 5-Fluorouracil-induced RNA stress engages a TRAIL-DISC-dependent apoptosis axis facilitated by p53. Oncotarget. 2015 Dec 22;6(41):43679-97. doi: 10.18632/oncotarget.6030.
67 Regulation of genes of the circadian clock in human colon cancer: reduced period-1 and dihydropyrimidine dehydrogenase transcription correlates in high-grade tumors. Cancer Res. 2007 Aug 15;67(16):7917-22. doi: 10.1158/0008-5472.CAN-07-0133.
68 p53-regulated transcriptional program associated with genotoxic stress-induced apoptosis. J Biol Chem. 2004 May 14;279(20):21183-92. doi: 10.1074/jbc.M311912200. Epub 2004 Mar 11.
69 Partial contribution of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/TRAIL receptor pathway to antitumor effects of interferon-alpha/5-fluorouracil against Hepatocellular Carcinoma. Clin Cancer Res. 2004 Dec 1;10(23):7884-95. doi: 10.1158/1078-0432.CCR-04-0794.
70 Transcriptional repression of IKK by p53 in arsenite-induced GADD45 accumulation and apoptosis. Oncogene. 2019 Jan;38(5):731-746. doi: 10.1038/s41388-018-0478-7. Epub 2018 Sep 3.
71 Combination therapy of interferon-alpha and 5-fluorouracil inhibits tumor angiogenesis in human hepatocellular carcinoma cells by regulating vascular endothelial growth factor and angiopoietins. Oncol Rep. 2007 Oct;18(4):801-9.
72 p53 regulates Toll-like receptor 3 expression and function in human epithelial cell lines. Mol Cell Biol. 2008 Nov;28(21):6557-67. doi: 10.1128/MCB.01202-08. Epub 2008 Sep 8.
73 Role of the Fas/FasL pathway in combination therapy with interferon-alpha and fluorouracil against hepatocellular carcinoma in vitro. J Hepatol. 2007 Jan;46(1):77-88. doi: 10.1016/j.jhep.2006.07.032. Epub 2006 Sep 25.
74 Rebamipide suppresses 5-fluorouracil-induced cell death via the activation of Akt/mTOR pathway and regulates the expression of Bcl-2 family proteins. Toxicol In Vitro. 2018 Feb;46:284-293. doi: 10.1016/j.tiv.2017.10.019. Epub 2017 Oct 17.
75 Characterization of DNA reactive and non-DNA reactive anticancer drugs by gene expression profiling. Mutat Res. 2007 Jun 1;619(1-2):16-29. doi: 10.1016/j.mrfmmm.2006.12.007. Epub 2007 Feb 8.
76 Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol. 2021 Apr;37(2):151-175. doi: 10.1007/s10565-020-09537-1. Epub 2020 Jun 14.
77 [Expression of APRIL in colorectal carcinoma tissues and effects of chemotherapeutic agents on APRIL expression in colorectal carcinoma SW480 cells]. Ai Zheng. 2008 Apr;27(4):369-73.
78 5-Fluorouracil inhibits neural differentiation via Mfn1/2 reduction in human induced pluripotent stem cells. J Toxicol Sci. 2018;43(12):727-734. doi: 10.2131/jts.43.727.
79 Cytotoxic Effects of Cannabinoids on Human HT-29 Colorectal Adenocarcinoma Cells: Different Mechanisms of THC, CBD, and CB83. Int J Mol Sci. 2020 Aug 1;21(15):5533. doi: 10.3390/ijms21155533.
80 Dynamic monitoring of cardio-specific markers and markers of thyroid gland function in cancer patients--a pilot study. Anticancer Res. 2007 Jul-Aug;27(4A):1883-6.
81 Topical fluorouracil for actinic keratoses and photoaging: a clinical and molecular analysis. Arch Dermatol. 2009 Jun;145(6):659-66. doi: 10.1001/archdermatol.2009.97.
82 Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: the roles of caspase-6 and p53. Cancer Biol Ther. 2008 Aug;7(8):1305-12. doi: 10.4161/cbt.7.8.6302. Epub 2008 Aug 16.
83 Thrombogenicity of intravenous 5-fluorouracil alone or in combination with cisplatin. Cancer. 1990 Feb 15;65(4):885-9. doi: 10.1002/1097-0142(19900215)65:4<885::aid-cncr2820650410>3.0.co;2-h.
84 Incorporation of 5-fluorouracil into U2 snRNA blocks pseudouridylation and pre-mRNA splicing in vivo. Nucleic Acids Res. 2007;35(2):550-8. doi: 10.1093/nar/gkl1084. Epub 2006 Dec 14.
85 Fluorouracil induces apoptosis and surface molecule modulation of peripheral blood leukocytes. Clin Lab Haematol. 2004 Oct;26(5):327-33. doi: 10.1111/j.1365-2257.2004.00629.x.
86 Antiproliferative effect of p-Coumaric acid targets UPR activation by downregulating Grp78 in colon cancer. Chem Biol Interact. 2018 Aug 1;291:16-28. doi: 10.1016/j.cbi.2018.06.001. Epub 2018 Jun 5.
87 P38 MAPK, NF-B, and JAK-STAT3 Signaling Pathways Involved in Capecitabine-Induced Hand-Foot Syndrome via Interleukin 6 or Interleukin 8 Abnormal Expression. Chem Res Toxicol. 2022 Mar 21;35(3):422-430. doi: 10.1021/acs.chemrestox.1c00317. Epub 2022 Feb 11.
88 The essential role of p53 in hyperpigmentation of the skin via regulation of paracrine melanogenic cytokine receptor signaling. J Biol Chem. 2009 Feb 13;284(7):4343-53. doi: 10.1074/jbc.M805570200. Epub 2008 Dec 18.
89 p53- and p21-independent apoptosis of squamous cell carcinoma cells induced by 5-fluorouracil and radiation. Oral Oncol. 1998 Nov;34(6):529-37. doi: 10.1016/s1368-8375(98)00036-0.
90 Differential activation of cell death and autophagy results in an increased cytotoxic potential for trifluorothymidine compared to 5-fluorouracil in colon cancer cells. Int J Cancer. 2010 May 15;126(10):2457-68. doi: 10.1002/ijc.24943.
91 The optimal schedule for 5-fluorouracil radiosensitization in colon cancer cell lines. Oncol Rep. 2006 Nov;16(5):1085-91.
92 Molecular basis for the induction of an angiogenesis inhibitor, thrombospondin-1, by 5-fluorouracil. Cancer Res. 2008 Sep 1;68(17):7035-41. doi: 10.1158/0008-5472.CAN-07-6496.
93 Down-regulation of Sonic hedgehog signaling pathway activity is involved in 5-fluorouracil-induced apoptosis and motility inhibition in Hep3B cells. Acta Biochim Biophys Sin (Shanghai). 2008 Sep;40(9):819-29.
94 DNA damaging drugs-induced down-regulation of Bcl-2 is essential for induction of apoptosis in high-risk HPV-positive HEp-2 and KB cells. Cancer Lett. 2006 May 18;236(2):213-21. doi: 10.1016/j.canlet.2005.05.024. Epub 2005 Jul 5.
95 Depletion of O6-methylguanine-DNA methyltransferase by O6-benzylguanine enhances 5-FU cytotoxicity in colon and oral cancer cell lines. Oncol Rep. 2007 Jun;17(6):1461-7.
96 The up-regulation of type I interferon receptor gene plays a key role in hepatocellular carcinoma cells in the synergistic antiproliferative effect by 5-fluorouracil and interferon-alpha. Int J Oncol. 2006 Dec;29(6):1469-78.
97 Establishment of a 13 genes-based molecular prediction score model to discriminate the neurotoxic potential of food relevant-chemicals. Toxicol Lett. 2022 Feb 1;355:1-18. doi: 10.1016/j.toxlet.2021.10.013. Epub 2021 Nov 5.
98 Adjuvant therapy with -tocopherol-induce apoptosis in HT-29 colon cancer via cyclin-dependent cell cycle arrest mechanism. J Biochem Mol Toxicol. 2019 Nov;33(11):e22399. doi: 10.1002/jbt.22399. Epub 2019 Oct 6.
99 5-Fluorouracil induces apoptosis through the suppression of NF-kappaB activity in human salivary gland cancer cells. Biochem Biophys Res Commun. 2000 Jul 14;273(3):1168-74. doi: 10.1006/bbrc.2000.3072.
100 Nicotine increases survival in human colon cancer cells treated with chemotherapeutic drugs. Toxicol In Vitro. 2013 Dec;27(8):2256-63. doi: 10.1016/j.tiv.2013.09.020. Epub 2013 Oct 2.
101 MAP kinase-signaling controls nuclear translocation of tripeptidyl-peptidase II in response to DNA damage and oxidative stress. Biochem Biophys Res Commun. 2010 Aug 27;399(3):324-30. doi: 10.1016/j.bbrc.2010.06.133. Epub 2010 Jul 17.
102 Constitutive expression of interleukin-18 in head and neck squamous carcinoma cells. Head Neck. 2004 Jun;26(6):494-503. doi: 10.1002/hed.20011.
103 Predictive value of GADD153, p21 and c-Jun for chemotherapy response in gastric cancer. Cancer Sci. 2007 May;98(5):707-15. doi: 10.1111/j.1349-7006.2007.00435.x. Epub 2007 Mar 9.
104 Development and applications of a real-time quantitative RT-PCR method (QRT-PCR) for BRCA1 mRNA. Clin Biochem. 2005 Jan;38(1):50-7. doi: 10.1016/j.clinbiochem.2004.09.012.
105 Regulation of p53 stability and function in HCT116 colon cancer cells. J Biol Chem. 2004 Feb 27;279(9):7598-605. doi: 10.1074/jbc.M311732200. Epub 2003 Dec 9.
106 The differential effects of cyclophosphamide, epirubicin and 5-fluorouracil on apoptotic marker (CPP-32), pro-apoptotic protein (p21(WAF-1)) and anti-apoptotic protein (bcl-2) in breast cancer cells. Breast Cancer Res Treat. 2003 Aug;80(3):239-44. doi: 10.1023/A:1024995202135.
107 TNFSF10 (TRAIL), a p53 target gene that mediates p53-dependent cell death. Cancer Biol Ther. 2008 Dec;7(12):2034-8. doi: 10.4161/cbt.7.12.7460.
108 Stunning and its effect on 3H-FDG uptake and key gene expression in breast cancer cells undergoing chemotherapy. J Nucl Med. 2006 Apr;47(4):603-8.
109 Cadmium modifies the cell cycle and apoptotic profiles of human breast cancer cells treated with 5-fluorouracil. Int J Mol Sci. 2013 Aug 12;14(8):16600-16. doi: 10.3390/ijms140816600.
110 Different responses to 5-fluoraouracil in mutagenicity and gene expression between two human lymphoblastoid cell lines with or without TP53 mutation. Acta Med Okayama. 2012;66(2):119-29. doi: 10.18926/AMO/48262.
111 The RNA exosome component hRrp6 is a target for 5-fluorouracil in human cells. Mol Cancer Res. 2008 Jun;6(6):990-5. doi: 10.1158/1541-7786.MCR-07-2217.
112 Evaluation of drug transporters' significance for multidrug resistance in head and neck squamous cell carcinoma. Head Neck. 2011 Jul;33(7):959-68. doi: 10.1002/hed.21559. Epub 2010 Aug 24.
113 Adenoviral-mediated gene transfer of Gadd45a results in suppression by inducing apoptosis and cell cycle arrest in pancreatic cancer cell. J Gene Med. 2009 Jan;11(1):3-13. doi: 10.1002/jgm.1270.
114 Enhanced Bax in oral SCC in relation to antitumor effects of chemotherapy. J Oral Pathol Med. 2005 Feb;34(2):93-9. doi: 10.1111/j.1600-0714.2004.00257.x.
115 gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity. Cancer Res. 2009 Jan 15;69(2):573-82. doi: 10.1158/0008-5472.CAN-08-2088.
116 Effect of resveratrol on proliferation and apoptosis of human pancreatic cancer MIA PaCa-2 cells may?involve inhibition of the Hedgehog signaling pathway. Mol Med Rep. 2014 Nov;10(5):2563-7. doi: 10.3892/mmr.2014.2511. Epub 2014 Aug 21.
117 YB-1 facilitates basal and 5-fluorouracil-inducible expression of the human major vault protein (MVP) gene. Oncogene. 2005 May 19;24(22):3606-18. doi: 10.1038/sj.onc.1208386.
118 An appraisal of cinnamyl sulfonamide hydroxamate derivatives (HDAC?inhibitors) for anti-cancer, anti-angiogenic and anti-metastatic activities in human cancer cells. Chem Biol Interact. 2016 Jun 25;253:112-24. doi: 10.1016/j.cbi.2016.05.008. Epub 2016 May 6.
119 GRAMD4 mimics p53 and mediates the apoptotic function of p73 at mitochondria. Cell Death Differ. 2011 May;18(5):874-86. doi: 10.1038/cdd.2010.153. Epub 2010 Dec 3.
120 Administration of PUMA adenovirus increases the sensitivity of esophageal cancer cells to anticancer drugs. Cancer Biol Ther. 2006 Apr;5(4):380-5. doi: 10.4161/cbt.5.4.2477. Epub 2006 Apr 4.
121 Chemopreventive agents induce programmed death-1-ligand 1 (PD-L1) surface expression in breast cancer cells and promote PD-L1-mediated T cell apoptosis. Mol Immunol. 2008 Mar;45(5):1470-6. doi: 10.1016/j.molimm.2007.08.013. Epub 2007 Oct 24.
122 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
123 Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy. Mol Cancer. 2011 Apr 13;10:37. doi: 10.1186/1476-4598-10-37.
124 Characterization of 5-fluorouracil-resistant cholangiocarcinoma cell lines. Chemotherapy. 2008;54(5):343-51. doi: 10.1159/000151541. Epub 2008 Aug 21.
125 Predicting 5-fluorouracil chemosensitivity of liver metastases from colorectal cancer using primary tumor specimens: three-gene expression model predicts clinical response. Int J Cancer. 2006 Jul 15;119(2):406-13. doi: 10.1002/ijc.21843.
126 Antiapoptotic protein partners fortilin and MCL1 independently protect cells from 5-fluorouracil-induced cytotoxicity. J Biol Chem. 2004 Sep 24;279(39):40868-75. doi: 10.1074/jbc.M401454200. Epub 2004 Jul 15.
127 Down-regulation of CYLD as a trigger for NF-B activation and a mechanism of apoptotic resistance in hepatocellular carcinoma cells. Int J Oncol. 2011 Jan;38(1):121-31.
128 Effect of focal adhesion kinase (FAK) downregulation with FAK antisense oligonucleotides and 5-fluorouracil on the viability of melanoma cell lines. Melanoma Res. 2005 Oct;15(5):357-62. doi: 10.1097/00008390-200510000-00003.
129 [Correlation of sorcin overexpression to multidrug resistance of human gastric cancer cell line SGC7901]. Ai Zheng. 2008 Apr;27(4):337-42.
130 Molecular characterizations of derivatives of HCT116 colorectal cancer cells that are resistant to the chemotherapeutic agent 5-fluorouracil. Int J Oncol. 2004 May;24(5):1279-88.
131 Impairment of APE1 function enhances cellular sensitivity to clinically relevant alkylators and antimetabolites. Mol Cancer Res. 2009 Jun;7(6):897-906. doi: 10.1158/1541-7786.MCR-08-0519. Epub 2009 May 26.
132 CD40 signaling activated by agonistic anti-CD40 monoclonal antibody 5C11 has different effects on biological behavior of gastric carcinoma cells. Immunol Lett. 2010 Jul 8;131(2):120-5. doi: 10.1016/j.imlet.2010.02.007. Epub 2010 Feb 25.
133 Expression of rTSbeta as a 5-fluorouracil resistance marker in patients with primary breast cancer. Oncol Rep. 2008 Apr;19(4):881-8.
134 Reversal of the malignant phenotype of gastric cancer cells by inhibition of RhoA expression and activity. Clin Cancer Res. 2004 Sep 15;10(18 Pt 1):6239-47. doi: 10.1158/1078-0432.CCR-04-0242.
135 Single-cell transcription site activation predicts chemotherapy response in human colorectal tumors. Cancer Res. 2008 Jul 1;68(13):4977-82. doi: 10.1158/0008-5472.CAN-07-6770.
136 Epidermal growth factor receptor vIII enhances tumorigenicity and resistance to 5-fluorouracil in human hepatocellular carcinoma. Cancer Lett. 2009 Jun 28;279(1):30-8. doi: 10.1016/j.canlet.2009.01.019. Epub 2009 Feb 12.
137 Reg IV is a serum biomarker for gastric cancer patients and predicts response to 5-fluorouracil-based chemotherapy. Oncogene. 2007 Jun 28;26(30):4383-93. doi: 10.1038/sj.onc.1210215. Epub 2007 Jan 22.
138 Overexpression of neuropilin-1 promotes constitutive MAPK signalling and chemoresistance in pancreatic cancer cells. Br J Cancer. 2005 Jul 25;93(2):233-41. doi: 10.1038/sj.bjc.6602663.
139 [Knock-down of apollon gene by antisense oligodeoxynucleotide inhibits the proliferation of Lovo cells and enhances chemo-sensitivity]. Yao Xue Xue Bao. 2011 Feb;46(2):138-45.
140 Overexpression and significance of prion protein in gastric cancer and multidrug-resistant gastric carcinoma cell line SGC7901/ADR. Int J Cancer. 2005 Jan 10;113(2):213-20. doi: 10.1002/ijc.20570.
141 A new high resolution screening method for study of phenotype stress responses of Saccharomyces cerevisae mutants. J Microbiol Methods. 2011 Dec;87(3):363-7. doi: 10.1016/j.mimet.2011.10.003. Epub 2011 Oct 8.
142 Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer. Gastroenterology. 2008 Oct;135(4):1358-1368, 1368.e1-4. doi: 10.1053/j.gastro.2008.06.082. Epub 2008 Jul 3.
143 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Cancer Sci. 2013 Aug;104(8):1074-82. doi: 10.1111/cas.12186. Epub 2013 Jun 10.
144 Decreased expression of hMLH1 correlates with reduced 5-fluorouracil-mediated apoptosis in colon cancer cells. Oncol Rep. 2007 Nov;18(5):1129-37.
145 Silencing of keratinocyte growth factor receptor restores 5-fluorouracil and tamoxifen efficacy on responsive cancer cells. PLoS One. 2008 Jun 25;3(6):e2528. doi: 10.1371/journal.pone.0002528.
146 Heat shock protein 27, a novel regulator of 5-fluorouracil resistance in colon cancer. Oncol Rep. 2008 Nov;20(5):1165-72.
147 Detection of potassium currents and regulation of multidrug resistance by potassium channels in human gastric cancer cells. Cell Biol Int. 2007 Jul;31(7):741-7. doi: 10.1016/j.cellbi.2007.01.008. Epub 2007 Jan 21.
148 Tudor staphylococcal nuclease drives chemoresistance of non-small cell lung carcinoma cells by regulating S100A11. Oncotarget. 2015 May 20;6(14):12156-73. doi: 10.18632/oncotarget.3495.
149 Targeted inhibition of Livin resensitizes renal cancer cells towards apoptosis. Cell Mol Life Sci. 2007 May;64(9):1137-44. doi: 10.1007/s00018-007-6510-7.
150 Therapeutic targeting of the endothelin a receptor in human nasopharyngeal carcinoma. Cancer Sci. 2006 Dec;97(12):1388-95. doi: 10.1111/j.1349-7006.2006.00333.x. Epub 2006 Oct 9.
151 Interferon-gamma sensitizes hepatitis B virus-expressing hepatocarcinoma cells to 5-fluorouracil through inhibition of hepatitis B virus-mediated nuclear factor-kappaB activation. Cancer Sci. 2007 Nov;98(11):1758-66. doi: 10.1111/j.1349-7006.2007.00591.x. Epub 2007 Aug 16.
152 Prediction of chemosensitivity using multigene analysis in head and neck squamous cell carcinoma. Oncology. 2007;73(1-2):104-11. doi: 10.1159/000120998. Epub 2008 Mar 13.
153 Alterations in the glycolipid composition and cellular properties of ovarian carcinoma-derived RMG-1 cells on transfection of the alpha1,2-fucosyltransferase gene. Cancer Sci. 2005 Jan;96(1):26-30. doi: 10.1111/j.1349-7006.2005.00005.x.
154 Inactivating mutation of the pro-apoptotic gene BID in gastric cancer. J Pathol. 2004 Apr;202(4):439-45. doi: 10.1002/path.1532.
155 Comparative proteomic analysis of SLC13A5 knockdown reveals elevated ketogenesis and enhanced cellular toxic response to chemotherapeutic agents in HepG2 cells. Toxicol Appl Pharmacol. 2020 Sep 1;402:115117. doi: 10.1016/j.taap.2020.115117. Epub 2020 Jul 4.
156 Genome-wide expression analysis of therapy-resistant tumors reveals SPARC as a novel target for cancer therapy. J Clin Invest. 2005 Jun;115(6):1492-502. doi: 10.1172/JCI23002. Epub 2005 May 12.
157 The epigenetic modifier HDAC2 and the checkpoint kinase ATM determine the responses of microsatellite instable colorectal cancer cells to 5-fluorouracil. Cell Biol Toxicol. 2023 Oct;39(5):2401-2419. doi: 10.1007/s10565-022-09731-3. Epub 2022 May 24.
158 Exogenous expression of hRFI induces multidrug resistance through escape from apoptosis in colorectal cancer cells. Anticancer Res. 2005 Jul-Aug;25(4):2737-41.
159 Regulation of multidrug resistance by ribosomal protein l6 in gastric cancer cells. Cancer Biol Ther. 2005 Feb;4(2):242-7. doi: 10.4161/cbt.4.2.1477. Epub 2005 Feb 20.
160 Antitumour effects on human colorectal carcinomas cells by stable silencing of phospholipase C-gamma 1 with lentivirus-delivered siRNA. Chin Med J (Engl). 2007 May 5;120(9):749-54.
161 Reversal of multidrug resistance of vincristine-resistant gastric adenocarcinoma cells through up-regulation of DARPP-32. Cell Biol Int. 2007 Sep;31(9):1010-5. doi: 10.1016/j.cellbi.2007.03.020. Epub 2007 Mar 21.
162 Rho/Rhotekin-mediated NF-kappaB activation confers resistance to apoptosis. Oncogene. 2004 Nov 18;23(54):8731-42. doi: 10.1038/sj.onc.1208106.
163 Proteomic identification of differentially expressed proteins associated with the multiple drug resistance in methotrexate-resistant human breast cancer cells. Int J Oncol. 2014 Jul;45(1):448-58.
164 ABCC11 expression is regulated by estrogen in MCF7 cells, correlated with estrogen receptor alpha expression in postmenopausal breast tumors and overexpressed in tamoxifen-resistant breast cancer cells. Endocr Relat Cancer. 2008 Mar;15(1):125-38. doi: 10.1677/ERC-07-0189.
165 Effects of folylpolyglutamate synthetase modulation on chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate. Gut. 2004 Dec;53(12):1825-31. doi: 10.1136/gut.2004.042713.
166 Periostin induction in tumor cell line explants and inhibition of in vitro cell growth by anti-periostin antibodies. Carcinogenesis. 2005 May;26(5):908-15. doi: 10.1093/carcin/bgi034. Epub 2005 Feb 24.
167 Interferons upregulate thymidine phosphorylase expression via JAK-STAT-dependent transcriptional activation and mRNA stabilization in human glioblastoma cells. J Neurooncol. 2005 May;72(3):217-23. doi: 10.1007/s11060-004-3012-4.
168 Galectin-3 germline variant at position 191 enhances nuclear accumulation and activation of -catenin in gastric cancer. Clin Exp Metastasis. 2011 Dec;28(8):743-50. doi: 10.1007/s10585-011-9406-8. Epub 2011 Jul 13.
169 Recombinant human erythropoietin alpha targets intratumoral blood vessels, improving chemotherapy in human xenograft models. Cancer Res. 2005 Aug 15;65(16):7186-93. doi: 10.1158/0008-5472.CAN-04-2498.
170 The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils. Blood. 2008 Mar 15;111(6):3097-107.
171 Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
172 The kinase inhibitor dasatinib induces apoptosis in chronic lymphocytic leukemia cells in vitro with preference for a subgroup of patients with unmutated IgVH genes. Blood. 2008 Aug 15;112(4):1443-52. doi: 10.1182/blood-2007-11-123984. Epub 2008 Jun 12.
173 A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.
174 Comparison of ATP-binding cassette transporter interactions with the tyrosine kinase inhibitors imatinib, nilotinib, and dasatinib. Drug Metab Dispos. 2010 Aug;38(8):1371-80.
175 Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti-cancer effects and pharmacological properties. Br J Pharmacol. 2009 Oct;158(4):1153-64.
176 Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66.
177 Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706.
178 Identification of the human enzymes involved in the oxidative metabolism of dasatinib: an effective approach for determining metabolite formation kinetics. Drug Metab Dispos. 2008 Sep;36(9):1828-39.
179 A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicol Sci. 2013 Nov;136(1):216-41.
180 Combination of arsenic trioxide and Dasatinib: a new strategy to treat Philadelphia chromosome-positive acute lymphoblastic leukaemia. J Cell Mol Med. 2018 Mar;22(3):1614-1626.
181 MEK/ERK dependent activation of STAT1 mediates dasatinib-induced differentiation of acute myeloid leukemia. PLoS One. 2013 Jun 25;8(6):e66915. doi: 10.1371/journal.pone.0066915. Print 2013.
182 Co-administration of NVP-AEW541 and dasatinib induces mitochondrial-mediated apoptosis through Bax activation in malignant human glioma cell lines. Int J Oncol. 2010 Sep;37(3):633-43. doi: 10.3892/ijo_00000712.
183 Combined BCR-ABL inhibition with lentiviral-delivered shRNA and dasatinib augments induction of apoptosis in Philadelphia-positive cells. Exp Hematol. 2009 Feb;37(2):206-14. doi: 10.1016/j.exphem.2008.10.013. Epub 2008 Dec 18.
184 Identification and Profiling of Environmental Chemicals That Inhibit the TGF/SMAD Signaling Pathway. Chem Res Toxicol. 2019 Dec 16;32(12):2433-2444. doi: 10.1021/acs.chemrestox.9b00228. Epub 2019 Nov 11.
185 Dasatinib, a small-molecule protein tyrosine kinase inhibitor, inhibits T-cell activation and proliferation. Blood. 2008 Feb 1;111(3):1366-77. doi: 10.1182/blood-2007-04-084814. Epub 2007 Oct 25.
186 Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury. J Toxicol Sci. 2021;46(4):167-176. doi: 10.2131/jts.46.167.
187 IL-8 and MCP-1/CCL2 regulate proteolytic activity in triple negative inflammatory breast cancer a mechanism that might be modulated by Src and Erk1/2. Toxicol Appl Pharmacol. 2020 Aug 15;401:115092. doi: 10.1016/j.taap.2020.115092. Epub 2020 Jun 5.
188 Distinct interactions between c-Src and c-Met in mediating resistance to c-Src inhibition in head and neck cancer. Clin Cancer Res. 2011 Feb 1;17(3):514-24. doi: 10.1158/1078-0432.CCR-10-1617. Epub 2010 Nov 24.
189 High-mobility group box 1 protein-mediated necroptosis contributes to dasatinib-induced cardiotoxicity. Toxicol Lett. 2018 Oct 15;296:39-47. doi: 10.1016/j.toxlet.2018.08.003. Epub 2018 Aug 4.
190 Dasatinib induces autophagic cell death in human ovarian cancer. Cancer. 2010 Nov 1;116(21):4980-90. doi: 10.1002/cncr.25426.
191 Dasatinib inhibits the growth of molecularly heterogeneous myeloid leukemias. Clin Cancer Res. 2010 Feb 15;16(4):1149-58. doi: 10.1158/1078-0432.CCR-09-2416. Epub 2010 Feb 9.
192 Dasatinib inhibits the growth and survival of neoplastic human eosinophils (EOL-1) through targeting of FIP1L1-PDGFRalpha. Exp Hematol. 2008 Oct;36(10):1244-53. doi: 10.1016/j.exphem.2008.04.017. Epub 2008 Jul 10.
193 Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res. 2006 Jun 1;66(11):5542-8. doi: 10.1158/0008-5472.CAN-05-4620.
194 Targeted inhibition of SRC kinase signaling attenuates pancreatic tumorigenesis. Mol Cancer Ther. 2010 Aug;9(8):2322-32. doi: 10.1158/1535-7163.MCT-09-1212. Epub 2010 Aug 3.
195 The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13283-8. doi: 10.1073/pnas.0702654104. Epub 2007 Aug 7.
196 Cotreatment with vorinostat (suberoylanilide hydroxamic acid) enhances activity of dasatinib (BMS-354825) against imatinib mesylate-sensitive or imatinib mesylate-resistant chronic myelogenous leukemia cells. Clin Cancer Res. 2006 Oct 1;12(19):5869-78. doi: 10.1158/1078-0432.CCR-06-0980.
197 Src inhibitor dasatinib inhibits growth of breast cancer cells by modulating EGFR signaling. Cancer Lett. 2009 Oct 8;283(2):143-51. doi: 10.1016/j.canlet.2009.03.035. Epub 2009 Apr 26.
198 Phosphorylation of hepatic farnesoid X receptor by FGF19 signaling-activated Src maintains cholesterol levels and protects from atherosclerosis. J Biol Chem. 2019 May 31;294(22):8732-8744. doi: 10.1074/jbc.RA119.008360. Epub 2019 Apr 17.
199 Identification of PKMYT1 inhibitors by screening the GSK published protein kinase inhibitor set I and II. Bioorg Med Chem. 2018 Aug 7;26(14):4014-4024. doi: 10.1016/j.bmc.2018.06.027. Epub 2018 Jun 20.
200 A high-throughput screen for teratogens using human pluripotent stem cells. Toxicol Sci. 2014 Jan;137(1):76-90. doi: 10.1093/toxsci/kft239. Epub 2013 Oct 23.
201 Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation. Cancer Discov. 2013 Jan;3(1):96-111. doi: 10.1158/2159-8290.CD-12-0031. Epub 2012 Nov 2.
202 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
203 Biologically active neutrophil chemokine pattern in tonsillitis.Clin Exp Immunol. 2004 Mar;135(3):511-8. doi: 10.1111/j.1365-2249.2003.02390.x.